Hyperthyroidism and hepatic dysfunction: the impact of congestive heart failure

Benothman, Wafa; Kacem, F. Hadj; Gargouri, I.; Elleuch, Mouna; Mnif, F.; Abid, Mohamed

doi:10.1530/endoabs.63.p1213

Cited by 1 publication

(3 citation statements)

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“…Typical histological findings include fatty infiltration of the hepatocytes, nuclear irregularity, hyperchromatism in hepatocytes and vacuolization of the cytoplasm. Cholestatic pattern is commoner than synthetic liver dysfunction, 18 and some may present with severe jaundice as the main presentation. Rises in ALP and GGT are seen about 64% and up to 62% of thyrotoxicosis cases respectively.…”

Section: Putative Mechanisms For Liver Dysfunction In Hyperthyroidismmentioning

confidence: 99%

Section: Putative Mechanisms For Liver Dysfunction In Hyperthyroidismmentioning

confidence: 99%

“…19,20 In one series, elevations in serum ALP were followed in frequency by increases in levels of GGT, bilirubin, and aminotransferases. 18 Elevation in ALP is due to increased osteoblastic activity and driven mainly by bone isoenzyme. 21 Congestive heart failure may occur as a complication of hyperthyroidism (thyrotoxic heart failure) or as a preexisting condition.…”

Section: Putative Mechanisms For Liver Dysfunction In Hyperthyroidismmentioning

confidence: 99%

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Hyperthyroidism and Liver Dysfunction: A Review of a Common Comorbidity

Yorke

2022

Clin Med Insights Endocrinol Diabetes

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Deranged liver enzymes due to hyperthyroidism rather than intrinsic liver pathology are not uncommon. The reported prevalence of liver biochemical abnormalities in patients with untreated thyrotoxicosis varies widely ranging from 15% to 76%. The suggested causes of liver dysfunction include direct hepatocyte injury, co-morbid heart failure, associated autoimmune conditions (especially in the setting of Graves’ Disease), preexisting liver disease and drugs including antithyroid medications. Although, some patients may have a pattern of mild liver injury, about 1% to 2% can have fulminant hepatitis. Liver enzymes can return to normalcy in as many as 77% to 83% of patients once the initiations of thionamides are started in a timely fashion, which can help forestall complications and prevent or minimize multi-organ dysfunction. Clinicians should maintain a high index of suspicion for underlying hyperthyroidism in patients presenting with unexplained liver dysfunction or unexplained jaundice.

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Section: Putative Mechanisms For Liver Dysfunction In Hyperthyroidismmentioning

confidence: 99%