Hyperthyroidism and the heart.

Wilkin, Terence J.

doi:10.1136/bmj.286.6376.1459

Cited by 11 publications

(2 citation statements)

References 23 publications

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“…Epinephrine, a stimulant of the alpha‐ and beta‐adrenergic receptors, is the most commonly used vasoconstrictive agent (Naftalin & Yagiela ). It may produce beta‐stimulation of the heart, which can be dangerous in patients with a heart condition, hyperthyroidism or high blood pressure (Christensen , Wilkin ). The risks of adverse reactions or toxicity resulting from single injections containing epinephrine are minimal.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the anaesthetic efficacy of epinephrine concentrations (1 : 80 000 and 1 : 200 000) in 2% lidocaine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized, double‐blind clinical trial

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Comparison of the anaesthetic efficacy of epinephrine concentrations (1 : 80 000 and 1 : 200 000) in 2% lidocaine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized, double‐blind clinical trial

et al. 2013

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“…This effect probably results from an increased adrenergic sensitivity in an increased number of beta-adrenoceptors, despite a de¬ creased catecholamine concentration (1)(2)(3)(4)(5), although some controversy exists concerning the regulation ofbetaadrenoceptors (6,7). These changes are partly ascribed to a direct effect ofthe hormones on the heart and partly to an apparently increased adrenergic effect.…”

mentioning

confidence: 99%

The effects of propranolol and verapamil on hyperthyroid heart symptoms and function, assessed by systolic time intervals

Nordin

Galløe²,

Ladefoged³

et al. 1993

Acta Endocrinologica

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The effects ofacute and chronic administration ofpropranolol and verapamil on heart rate and systolic time intervals were studied in 10 hyperthyroid patients and 10 normal subjects, both groups without signs of cardiovascular or pulmonary disease. In normal subjects iv propranolol reduced heart rate significantly, and both drugs increased the total electromechanical systole significantly without difference between the drugs. This effect was insignificant when the drugs were given orally. In hyperthyroid patients both drugs reduced heart rate significantly in acute and chronic administration, and no difference between the two drugs was found. Neither drug altered cardiac contractility as assessed by systolic time intervals. These results indicate that the metabolic effects of thyroid hormone on contractility were unaltered and unblocked by the drugs. None of the participants developed signs of heart failure. Verapamil can thus be used as an alternative to propranolol in the treatment of tachycardia in hyperthyroidism. Henrik Nordin, Hostrups have 5,ltv, DK-1954 Frederiksberg C, Denmark

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Continuous 24-hour electrocardiography in thyrotoxicosis before and after treatment

Northcote

Macfarlane

Kesson

et al. 1986

American Heart Journal

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Hyperthyroidism and the heart.

Cited by 11 publications

References 23 publications

Comparison of the anaesthetic efficacy of epinephrine concentrations (1 : 80 000 and 1 : 200 000) in 2% lidocaine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized, double‐blind clinical trial

Comparison of the anaesthetic efficacy of epinephrine concentrations (1 : 80 000 and 1 : 200 000) in 2% lidocaine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized, double‐blind clinical trial

The effects of propranolol and verapamil on hyperthyroid heart symptoms and function, assessed by systolic time intervals

Continuous 24-hour electrocardiography in thyrotoxicosis before and after treatment

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