1978
DOI: 10.1056/nejm197806082982301
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Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-II

Abstract: A 59-year-old man with severe hypertriglyceridemia and no post-heparin lipolytic activity was studied because of a marked fall in plasma triglyceride concentrations after a blood transfusion. An apolipoprotein activator (apolipoprotein C-II) for lipoprotein lipase could not be detected by polyacrylamide-gel electrophoresis of apoproteins, immunodiffusion of the plasma against anti-apolipoprotein CII or activation assays for lipoprotein lipase. Furthermore, the patient's triglyceride-rich lipoproteins would not… Show more

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Cited by 573 publications
(198 citation statements)
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“…The modulation of LPL enzymic activity by apolipo- protein C-II has been actively investigated [4,5,[20][21][22] and the physiological importance of this regulation is apparent from the low LPL activity and hypertriglyceridemia reported in patients with apoC-II deficiency [8]. The regulation of HL activity has received much less attention [3,14] and there has been, to our knowledge, no previous report of specific activators of this enzyme.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The modulation of LPL enzymic activity by apolipo- protein C-II has been actively investigated [4,5,[20][21][22] and the physiological importance of this regulation is apparent from the low LPL activity and hypertriglyceridemia reported in patients with apoC-II deficiency [8]. The regulation of HL activity has received much less attention [3,14] and there has been, to our knowledge, no previous report of specific activators of this enzyme.…”
Section: Resultsmentioning
confidence: 99%
“…Type I hyperlipoproteinemia is associated with a deficiency in the enzymic activity of LPL [7]. A deficiency in apoC-1I also results in type I hyperlipoproteinemia [8] and LPL and apoC-I1 have therefore been proposed to be of major importance in modulating the catabolism of triglyceride-rich lipoproteins in man. The function, natural substrate and regulation of the enzymic activity of ilL have been less well defined.…”
Section: Introductionmentioning
confidence: 99%
“…18 In particular, 5 of 8 extensively studied apo CII-T homozygotes had low but detectable HL activity. This finding suggested the possibility that these subjects were heterozygous for a lossof-function mutation in HL.…”
mentioning
confidence: 97%
“…Knowledge äbout the concentration of the C-apolipo-Deficiency of apolipoprotein C-II has been shown to proteins, which -together with apolipoproteins B result in hypertriglyceridaemia (3). Apolipoprotein and E -are majqr äpoproteins of triglyceride-rich C-III seems to prevent the hepatic uptake of triglyclipoproteins, is rather liinited.…”
Section: Introductionmentioning
confidence: 99%