Hypertriglyceridemia is Frequent in Endometrial Cancer Survivors

Abstract

ObjectivePrevious studies have reported an association between endometrial cancer and the risk of metabolic syndrome; however, the pattern of endometrial cancer-associated dyslipidemia is not well understood. The standard therapy for endometrial cancer is total abdominal hysterectomy and bilateral salpingo-oophorectomy. Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia. Gynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic.MethodsThis study included 693 patients who had undergone bilateral salpingo-oophorectomy, and included 412 women with incident endometrial cancer and 281 controls. We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy. Serum lipid levels were measured and statistically analyzed.ResultsHypertriglyceridemia was statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy both before and after menopause than in the corresponding non-endometrial cancer controls. High levels of low-density lipoprotein cholesterol and a high low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy before menopause than in non-endometrial cancer controls.ConclusionsOur report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors.

Osteoporosis is less frequent in endometrial cancer survivors with hypertriglyceridemia

“…Therefore, the prevention of these diseases may lead to an improved QOL for EC survivors as well as post-menopausal women in general. TG levels are elevated in EC patients (1). Furthermore, we confirmed that OP occurs more frequently in non-EC hypercholesterolemia patients.…”

“…Some studies have reported an association between EC and the risk of dyslipidemia (1,12,19). These findings suggest that common metabolic abnormalities may act to increase dyslipidemia, OP and EC risk, but detailed data on the pathways connecting these conditions are limited.…”

“…This study is a subanalysis of our previous study, and all cases were included in our previous study (1).…”

“…Our recent research revealed that hypertriglyceridemia is frequent in endometrial cancer (EC) survivors (1). Previous studies have reported that dyslipidemia is an independent risk factor for decreased bone mass in post-menopausal women (2,3).…”

Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding

“…It was shown that higher prevalence of hypertension in patients with endometrial carcinoma could again be related to hyperinsulinemia and insulin resistance [5]. In a recent study, hypertension, diabetes, glucose levels and the consumption of high-glycemic load foods have been found to be positively associated with endometrial cancer risk only among overweight or obese women [25]. In consistency with that finding, the prevalence of hypertension and diabetes were detected higher among the women with cancer and hyperplasia.…”