Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding

Özdemir, Suna; Batmaz, Gonca; Ates, Seda; Çelık, Çetin; Incesu, F.; Peru, Celalettin

doi:10.3109/09513590.2015.1058355

Cited by 15 publications

(16 citation statements)

References 22 publications

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“…The same is detected in our study in form of significant increase in serum total cholesterol levels in EH‐induced group compared with control. That is in accordance with Özdemir et al and Romualdi et al . On addition of DIA, it succeeded in normalization of total cholesterol levels compared to EB‐induced EH and atypia due to its anti‐inflammatory, antioxidant, and lipid lowering effects .…”

Section: Discussionsupporting

confidence: 90%

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The role of interleukin‐1b and its antagonist (diacerein) in estradiol benzoate‐induced endometrial hyperplasia and atypia in female rats

Refaie

El-Hussieny

2017

Fundamemntal Clinical Pharma

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Endometrial hyperplasia (EH) is a common gynecological condition and may progress to carcinoma. We investigated the effect of diacerein (DIA) on estradiol benzoate (EB)-induced EH and atypia. DIA (50 mg/kg/day) was administered orally to rats for 4 weeks, in the presence or absence of EH induced by intramuscular injection of EB (60 μg/100 g) three times per week for 4 weeks. We measured levels of serum total cholesterol, uterine tissue malondialdehyde (MDA), total nitrites (NO ), superoxide dismutase (SOD) activity, caspase-3, interleukin-1b (IL-1b) immunoexpressions, and histopathology. Results showed that EB-induced EH and atypia manifested by significant increase in serum total cholesterol with increase in MDA and NO levels. EB showed the typical histopathological changes of EH and atypia. In addition, there was reduction in SOD activity and decrease in caspase-3 immunoexpressions but increase in IL-1b immunoexpressions. DIA was able to reduce EB-induced pathological changes.

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Section: Discussionsupporting

confidence: 90%

“…Hypertension, elevated levels of glucose, total cholesterol, LDL‐cholesterol, and reduced levels of HDL‐cholesterol were detected among women with EH and EC . The same is detected in our study in form of significant increase in serum total cholesterol levels in EH‐induced group compared with control.…”

Section: Discussionsupporting

confidence: 88%

The role of interleukin‐1b and its antagonist (diacerein) in estradiol benzoate‐induced endometrial hyperplasia and atypia in female rats

Refaie

El-Hussieny

2017

Fundamemntal Clinical Pharma

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“…However, the strength of such an association varies depending on age, BMI, and menopausal status, and one cohort study demonstrated that blood glucose levels are not associated with EC [ 93 ]. Five large-scale case-control studies demonstrated significantly higher blood glucose levels in women with ECs than controls [ 37 , 99 , 100 , 101 , 102 ].…”

Section: Is Diabetes Mellitus No Longer a Risk Factor For Ec?mentioning

confidence: 99%

Endometrial Cancer as a Metabolic Disease with Dysregulated PI3K Signaling: Shedding Light on Novel Therapeutic Strategies

Kyo

Nakayama

2020

IJMS

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Endometrial cancer (EC) is one of the most common malignancies of the female reproductive organs. The most characteristic feature of EC is the frequent association with metabolic disorders. However, the components of these disorders that are involved in carcinogenesis remain unclear. Accumulating epidemiological studies have clearly revealed that hyperinsulinemia, which accompanies these disorders, plays central roles in the development of EC via the insulin-phosphoinositide 3 kinase (PI3K) signaling pathway as a metabolic driver. Recent comprehensive genomic analyses showed that over 90% of ECs have genomic alterations in this pathway, resulting in enhanced insulin signaling and production of optimal tumor microenvironments (TMEs). Targeting PI3K signaling is therefore an attractive treatment strategy. Several clinical trials for recurrent or advanced ECs have been attempted using PI3K-serine/threonine kinase (AKT) inhibitors. However, these agents exhibited far lower efficacy than expected, possibly due to activation of alternative pathways that compensate for the PIK3-AKT pathway and allow tumor growth, or due to adaptive mechanisms including the insulin feedback pathway that limits the efficacy of agents. Overcoming these responses with careful management of insulin levels is key to successful treatment. Further interest in specific TMEs via the insulin PI3K-pathway in obese women will provide insight into not only novel therapeutic strategies but also preventive strategies against EC.

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“…30,31 Abnormalities in endometrium are noted due to diabetes, obesity, hyperglycemia, and hyperlipidemia. 32 F I G U R E 1 Various phenotypes of polycystic ovary syndrome PCOS patients also appear to have increased levels of palmitoyl sphingomyelin (SM), cyclic guanosine monophosphate (cGMP), and dehydroepiandrosterone sulfate (DHEAS). 33 Elevated levels of sphingolipids are also one of the significant findings in CVD.…”

Section: Cardiovascular Diseases Metabolic Syndrome and Diabetes mentioning

confidence: 99%

Human immunodeficiency: Extragonadal comorbidities of infertility in women

Lorzadeh

Kazemirad

2020

Immunity Inflam & Disease

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Introduction: Infertility is mediated by several changes system-wide. These changes are likely to cause other systems-related pathologies, such as changes in systemic immune response, particularly inflammatory response can lead to cardiovascular diseases and breast cancer. Methods: These morbidities can exist immediately or years after the diagnosis of infertility. Therefore, understanding the mechanism is important to move toward therapeutic interventions. Results: Several extragonadal pathologies are reported due to infertility, as well as, how these might also contribute to reproductive disabilities. Detailed evidence are still not present that can give stronger result. Conclusion: This review highlights some of the most frequent comorbidities that are seen in infertile women, hence requiring a need for complete clinical screening and care, as well as diagnosis and treatment in early stages. K E Y W O R D S extragonadal comorbidities, infertile women, infertility 1 | INTRODUCTION Up to 18% of general population is prone to infertility. 1 However, fewer studies target coexisting pathologies with infertility. Infertility is not a remote pathology and it can proffer effects on various systems in the body. Women infertility can have several causes, such as polycystic ovary syndrome (PCOS), endometriosis, tubal blockage, and hydrosalpinges. 2-4 Despite, availability of diversity of treatment options, prevalence extragonadal pathologies might influence the treatment outcomes for infertility. 5,6 Certain dietary intake can also elevate the risk to attain infertility. 7 A study reports genital infections like those in vagina, uterus, and ovaries that greatly contributes to infertility rather than cardiovascular factors. 8 PCOS is characterized by various phenotypes (Figure 1) and thereby existence of comorbidities varies according to each category. In general, these women present elevated body mass index (BMI), follicle count

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Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding

Abstract: Metabolic syndrome and its components have been shown to have profound impacts on initiation and progession of endometrial pathology, particularly during post-menopausal period.

Cited by 15 publications

References 22 publications

The role of interleukin‐1b and its antagonist (diacerein) in estradiol benzoate‐induced endometrial hyperplasia and atypia in female rats

The role of interleukin‐1b and its antagonist (diacerein) in estradiol benzoate‐induced endometrial hyperplasia and atypia in female rats

Endometrial Cancer as a Metabolic Disease with Dysregulated PI3K Signaling: Shedding Light on Novel Therapeutic Strategies

Human immunodeficiency: Extragonadal comorbidities of infertility in women

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