Hypertriglyceridemia

Elkins, Casey; Friedrich, Debra

doi:10.1097/01.npr.0000544997.22887.0b

Cited by 18 publications

(9 citation statements)

References 17 publications

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“…However, there are more problems than benefits if TGs are produced in excess [32]. In addition, the in vivo lipid imbalance caused by HFC diets increases the concentration of plasma lipoprotein LDL cholesterol and reduces the HDL cholesterol levels, leading to cardiovascular diseases, such as hypertension and arteriosclerosis [33,34]. Therefore, in hypertriglyceridemia induced by an HFC diet, RN intake can be useful in the treatment of cardiovascular diseases, as it can decrease TG, LDL, and HDL levels [32,33].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Hypertriglyceridemia by Roasted Nelumbinis folium in High Fat/High Cholesterol Diet Rat Model

et al. 2020

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Hypertriglyceridemia is a condition characterized by high triglyceride levels and is a major risk factor for the development of cardiovascular diseases. The present study was designed to investigate the inhibitory effect of roasted Nelumbinis folium (RN), which is a medicinal substance produced by heating lotus leaves, on lipid metabolism in high fat/cholesterol (HFC) diet-induced hypertriglyceridemia. Except for those in the control group, Sprague–Dawley rats were fed an HFC diet for four weeks to induce hypertriglyceridemia. During the next nine weeks, the control, regular diet; HFC, HFC diet, FLU, fluvastatin (3 mg/kg/day); RNL, RN (100 mg/kg/day); RNH, RN (200 mg/kg/day) were orally administered together with the diet, and the experiments were conducted for a total of 13 weeks. The weight of the epididymal adipose tissue, liver, and heart of rats in the HFC diet group significantly increased compared to those in the control group but improved in the RN-treated group. It was also confirmed that vascular function, which is damaged by an HFC diet, was improved after RN treatment. The levels of insulin, glucose, triglycerides, total cholesterol, and low-density lipoprotein increased in the HFC diet group compared to those in the control group, while the administration of RN attenuated these parameters. In addition, the administration of RN significantly reduced the gene expression of both LXR and SREBP-1, which indicated the inhibitory effect of the biosynthesis of triglycerides caused by RN. The results indicated that RN administration resulted in an improvement in the overall lipid metabolism and a decrease in the concentration of triglycerides in the HFC diet-induced rat model of hypertriglyceridemia. Therefore, our findings suggest that the RN can be a candidate material to provide a new direction for treating hypertriglyceridemia.

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Section: Discussionmentioning

confidence: 99%

Improvement of Hypertriglyceridemia by Roasted Nelumbinis folium in High Fat/High Cholesterol Diet Rat Model

et al. 2020

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“…Special modifications of diets focus mostly on decreasing total and saturated lipid and cholesterol, less received plain carbohydrates, receiving fibers from fruits and vegetables, and omega 3 fatty acids from fish, especially in children with hypertriglyceridemia. [ 28 39 40 ] The declining effect of fish oil on TG depends on the content of omega 3 fatty acids, including Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). It is believed that omega-3 fatty acids can cause the decreased synthesis of TGs in the liver and increased oxidation of fatty acids, which in turn results in less secretion of very-low-density lipoprotein (VLDL).…”

Section: Management and Treatment Of Dlpmentioning

confidence: 99%

“…When pharmacotherapy starts, it is necessary to continue the lifestyle as a synergic mechanism to decrease LDL-C or TG. [ 1 40 ] DLP pharmacotherapy is recommended for over-10-year-old children who have not been cured. Pharmacotherapy to decrease LDL-C starts for children without other CVD risk factors or CVD family background if, despite food interventions, LDL-C remains ≥190 mg/dl.…”

Section: Management and Treatment Of Dlpmentioning

confidence: 99%

“…Fibric acid derivatives, including Bezafibrate, Gemfibrozil, Ciprofibrate, and Fenofibrate, act as primary ligands of the nuclear transcription factor of the peroxisome proliferator-activated receptor (PPAR-alpha) receptor. [ 40 56 ] They increase the expression of lipase and downregulate apo-C-III, which is a lipolysis inhibitor that consequently destroys VLDL-C and TG in plasma. Also, HDL cholesterol level increases on average.…”

Section: Non-confirmed Pharmacotherapy For Children With Dlpmentioning

confidence: 99%

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Dyslipidemia in youth: Epidemiology, pathophysiology, screening, management, and treatment: A review of the literature

Esfarjani

Zakerkish

2022

Journal of Family Medicine and Primary Care

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A BSTRACT Atherosclerotic cardiovascular disease (ASCVD) is one of the major causes of death all over the world. Atherosclerosis is developed by atherogenic lipoproteins and inflammation. Thus, dyslipidemia (DLP) is a major risk factor for developing ASCVD. DLP is a condition characterised by unnaturally high levels of one or more lipid or lipoproteins in plasma. Although clinical manifestations of atherosclerosis are observed in middle age and above, atherosclerosis is a paediatric problem with a faster pathological procedure. Hence, increased awareness of the process of diagnosis, management, and treatment of children and adolescents with inherited or acquired DLPs among physicians and paediatricians is useful to prevent ASCVD in the future. The physicians and paediatricians must be aware of the current recommendations on DLP screening, pathophysiology, strategies for lifestyle modifications, pharmacotherapy, and guidelines for constant monitoring to better management of the disease. One of the most effective ways of managing DLP in childhood is to change lifestyle, in which parents have a critical role. In critical conditions, pharmacological interventions, along with changing lifestyle, may have significant effects on treating DLP. The aim of the present review was to investigate the epidemiology, pathophysiology, screening, management, and early treatment of DLP in youth. The data collected in this study increases our understanding of the importance of screening, management, and early treatment of DLP in order to prevent later risks and side effects that might even be life-threatening.

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“…[ 13–15 ] Hyperlipidemia is commonly seen with obesity and T2D. [ 16 ] We speculate that dietary factors which contribute to these metabolic disorders may be involved in the development of vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D‐25‐Hydroxylase Expression and Serum 25‐Hydroxyvitamin D₃ Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels

Zhu

Zhao

Zhuo

et al. 2021

Molecular Nutrition Food Res

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Scope Low circulating 25‐hydroxyvitamin D (25(OH)D) levels associate with obesity, diabetes, and hyperlipidemia, but the underlying mechanisms remain uncertain. As energy‐dense diet contributes to these disorders, this study investigates whether diet could impair vitamin D metabolism. Methods and Results Compared with control chow‐fed mice, high fat diet (HFD)‐fed mice show lower serum 25(OH)D3 and 1,25(OH)2D3 levels, lower hepatic vitamin D 25‐hydroxylase Cyp2r1 expression but comparable renal vitamin D metabolic enzymes expression. Time course studies show that after HFD feeding, the serum concentrations of cholesterol, triglycerides, fatty acids, glucose, and insulin elevate sequentially and before the reduction of hepatic Cyp2r1 expression and serum 25(OH)D3 levels. Hepatic Cyp2r1 expression also reduces after consuming high fat and high sucrose diet. After high cholesterol diet feeding, serum total cholesterol rises and hepatic Cyp2r1 expression decreases ahead of the reduction of serum 25(OH)D3. In vitro studies demonstrate that high concentrations of cholesterol, glucose, and insulin significantly inhibit Cyp2r1expression in primary murine hepatocytes. Further studies show that dietary restriction in HFD‐fed mice ameliorates hypercholesterolemia, hyperglycemia, and hypertriglyceridemia, and elevates hepatic Cyp2r1 expression and serum 25(OH)D3 level. Conclusion These findings suggest that diet‐induced elevation of circulating cholesterol, glucose, and insulin reduces serum 25(OH)D3 level through suppressing hepatic Cyp2r1 expression.

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Hypertriglyceridemia

Cited by 18 publications

References 17 publications

Improvement of Hypertriglyceridemia by Roasted Nelumbinis folium in High Fat/High Cholesterol Diet Rat Model

Improvement of Hypertriglyceridemia by Roasted Nelumbinis folium in High Fat/High Cholesterol Diet Rat Model

Dyslipidemia in youth: Epidemiology, pathophysiology, screening, management, and treatment: A review of the literature

High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D‐25‐Hydroxylase Expression and Serum 25‐Hydroxyvitamin D₃ Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels

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Hypertriglyceridemia

Cited by 18 publications

References 17 publications

Improvement of Hypertriglyceridemia by Roasted Nelumbinis folium in High Fat/High Cholesterol Diet Rat Model

Improvement of Hypertriglyceridemia by Roasted Nelumbinis folium in High Fat/High Cholesterol Diet Rat Model

Dyslipidemia in youth: Epidemiology, pathophysiology, screening, management, and treatment: A review of the literature

High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D‐25‐Hydroxylase Expression and Serum 25‐Hydroxyvitamin D3 Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels

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About

High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D‐25‐Hydroxylase Expression and Serum 25‐Hydroxyvitamin D₃ Level through Elevating Circulating Cholesterol, Glucose, and Insulin Levels