Hypertrophic osteoarthropathy associated with carcinoma of the oesophagus

Maurice‐Williams, R. S.; Wilson, R. J.

doi:10.1136/pgmj.45.529.743

Cited by 12 publications

(1 citation statement)

References 21 publications

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“…Oesophageal disease has been reported infrequently as a cause. Myomata (Joplin and Fraser, 1965), carcinoma (Maurice-Williams and Wilson, 1969;Coury, 1962), achalasia with carcinoma (Peyman, 1959), and achalasia without carcinoma (Naish, 1959) have been reported. Other gastrointestinal lesions associated with HO include nasopharyngeal carcinoma (Josserand, Pichat, and Chapuis, 1953), stomach cancer (Singh, Jolly, and Bansal, 1960), stomach diverticulum (Turiaf, Battesti, and Hardouin, 1966), hepatic cirrhosis (Buchan and Mitchell, 1967), and sprue (Hammersten and O'Leary, 1957).…”

Section: Discussionmentioning

confidence: 99%

A common factor in hypertrophic osteoarthropathy

Carroll

Doyle

1974

Thorax

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L. (1974). Thorax, 29,[262][263][264]. A common factor in hypertrophic osteoarthropathy. Two cases of oesophageal disease with hypertrophic osteoarthropathy are presented. The unusual site of the primary lesion has prompted a review of the literature and led to the conclusion that there is a common innervation accounting for a common afferent arc which is an integral and basic part of the mechanism in this disorder.The pathogenesis of hypertrophic osteoarthro-barium swallow showed the presence of a sliding pathy (HO) remains an enigma. It may be hiatus hernia. Oesophagoscopy revealed the presence associated with disease in a variety of organs and of severe confluent, ulcerative oesophagitis from in a wide range of pathological conditions in the cardia to the level of the aortic arch. those organs. We present two unusual and rare Repair of the hiatus hernia was carried out in causes of HO and propose a common factor in all cases of HO. CASE REPORTS PATIENT 3. M. A 78-year-old woman presented in 1959 with a three-month history of increasing dysphagia. For four to five months before admission she had noted swelling and stiffness in both ankles and wrists. Pitting oedema was easily demonstrable on the dorsum of the feet, ankles, and lower part of the legs and on the dorsum of the hands. Radiographs showed well-marked periosteal new bone formation on the tibiae, fibulae (Fig. 1), radii, and ulnae. Chest films and bronchoscopy were normal; in particular there was no evidence of bronchial carcinoma. Oesophagoscopy and biopsy revealed an adenocarcinoma in the middle third of the oesophagus.In view of the patient's age and frailty no operative intervention was undertaken and she died shortly after.PATIENT S. L. A 51-year-old man presented with a 10-year history of heartburn, especially at night; vomiting, occasionally with blood, was noted several times. From 1969 he had had aerophagy and slight dysphagia referred to the lower half of the sternum. From 1968 he had swollen and stiff ankles, stiff knees and wrists, and marked finger and toe clubbing.The chest film appearances were normal, but radiographs of the femora, tibiae, fibulae, and radii (Fig. 2

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Section: Discussionmentioning

confidence: 99%

A common factor in hypertrophic osteoarthropathy

Carroll

Doyle

1974

Thorax

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Gastroesophageal Reflux With Protein-Losing Enteropathy and Finger Clubbing

Herbst¹,

Johnson²,

Oliveros³

1976

Arch Pediatr Adolesc Med

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Periosteal new bone formation in polyarteritis nodosa. A syndrome involving the lower extremities

Woodward

Andreini

1974

Arthritis & Rheumatism

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Three patients with polyarteritis nodosa associated with periosteal new bone formation in the lower extremities are described. Seven cases with many similar features have been collected from the literature. Pain, swelling, and skin changes in the lower extremity with periosteal reaction seem to characterize one of the syndromes found in polyarteritis nodosa.Diffuse periosteal new bone formation is an uncommon feature of polyarteritis nodosa, but it does occur in association with a specific set of symptoms and findings.The unusual roentgenographic findings in case 1 prompted us to review the roentgenograms of other patients with polyarteritis nodosa. From 1968 to 1972, one hundred fifty-eight patients with a diagnosis of polyarteritis nodosa have been seen at the Mayo Clinic. This diagnosis was proposed on the basis of clinical findings and confirmed by histologic examination of biopsy specimens. Approximately half of these patients had had roentgenograms made of one or more of their extremities. A review of these roentgenograms disclosed two additional cases associated with periosteal new bone formation. REPORT OF CASESCase 1. A 46-year-old male teacher came to the Mayo Clinic in November 1971 because of pain and ulceration of the skin on the dorsum of the right foot. He had had recurrent ulcers on the right, and occasionally the left, ankle and foot since 1963, with exacerbations usually in the fall of each year. Investigation at another institution in March 1967 revealed electromyographic evidence of a peripheral neuropathy involving both lower extremities. Skin biopsy a t that time was reported to be negative. In December 1970 he was again extensively investigated at the same institution. T h e skin biopsy at that time revealed acute and subacute inflammation in the superficial dermis. T h e eosinophil count and the serum glutamic-oxalacetic transaminase (SGOT) value were increased.When the patient was first examined at the Mayo Clinic he complained of aching pain of such severity that he was unable to perform his teaching duties. There was mild swelling of the lower part of the right leg and the ankle, with a blotchy bluish discoloration of the skin. There were numerous circular brown macules and a large ulcer. L'aricose veins were not prominent and arterial pulsations were normal.Relevant laboratory data were: hemoglobin, 10.4 g/ 100 ml; erythrocyte count, 4,43O,OOO/cu mm; leukocyte count, 8,20O/cu mm with 11.5% eosinophils; peripheral blood smear, consistent with blood-loss anemia; erythrocyte sedimentation rate, 73 mm in 1 hour (Westergren); SGOT, 15 IU/liter; sulfobromophthalein (BSP) retention, 23% in 1 hour; serum protein electrophoresis, albumin 3.43 g/ 100m1, al-globulin 0.22 g/100 ml, =,-globulin 0.73

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Hypertrophic osteoarthropathy associated with carcinoma of the oesophagus

Cited by 12 publications

References 21 publications

A common factor in hypertrophic osteoarthropathy

A common factor in hypertrophic osteoarthropathy

Gastroesophageal Reflux With Protein-Losing Enteropathy and Finger Clubbing

Periosteal new bone formation in polyarteritis nodosa. A syndrome involving the lower extremities

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