Hypertrophy of the inferior olives

Jellinger, K. A.

doi:10.1007/bf00316018

Cited by 56 publications

(53 citation statements)

References 24 publications

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“…Although virtually all patients who develop palatal myoclonus after a brainstem insult will have HOD (28), not all patients with HOD also develop palatal myoclonus (2,20).…”

Section: Discussionmentioning

confidence: 99%

Midbrain tremor and hypertrophic olivary degeneration after pontine hemorrhage

et al. 1997

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A severe rest tremor arose in a patient's right arm 9 months after a pontine tegmental hemorrhage. Magnetic resonance studies at 4 and 10 months showed residual hemosiderin in the pons and increasing hypertrophic olivary degeneration (HOD) affecting primarily the left olive. The tremor was refractory to pharmacotherapy (clonazepam, propranolol, and levodopa), but was reduced after implantation of a thalamic stimulator device. Although pontine hemorrhage is among several common causes of HOD, it has not previously been appreciated as a cause of midbrain ("rubral") tremor. A disynaptic dentatorubroolivary tract associated with tremor and monosynaptic dentatoolivary tract associated with HOD may both be components of the rubroolivocerebellorubral loop implicated in midbrain tremor. Their proximity makes the combination of tremor and HOD after pontine tegmental damage plausible and even likely.

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“…Although virtually all patients who develop palatal myoclonus after a brainstem insult will have HOD (28), not all patients with HOD also develop palatal myoclonus (2,20).…”

Section: Discussionmentioning

confidence: 99%

Midbrain tremor and hypertrophic olivary degeneration after pontine hemorrhage

et al. 1997

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“…Whether the pathological time course of HOD can be considered in six stages, as described by Hornyak et al [10] and Goto and Kaneko [16], or in three stages, as described by Ash and Srinivasan [3], both histological and radiological changes begin to appear approximately 3 weeks after the injury. Jellinger [17] reported that early vacuolation occurring with in 15-20 days was responsible for the T 2 signal increase also seen around the third week following tissue damage. Olivary enlargement follows T 2 hyperintensity and can persist for years.…”

Section: Previous Reports On Hypertrophic Olivary Degenerationmentioning

confidence: 99%

Hypertrophic olivary degeneration in children: four new cases and a review of the literature with an emphasis on the MRI findings

Sanverdi¹,

Oguz²,

Haliloğlu³

2012

BJR

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ABSTRACT. Injury to the dentato-rubro-olivary pathway causes hypertrophy and enlargement of the inferior olivary nuclei, which is called hypertrophic olivary degeneration (HOD). To date, adult cases of HOD have usually been reported, and there are only a few individual paediatric cases with limited radiological emphasis in the literature. We present the clinical and MRI findings of four new paediatric cases with HOD. Three of the patients had a posterior fossa surgery, and one did not have an identifiable cause.

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“…Olivary hypertrophy is generally regarded as resulting from transsynaptic degeneration after disruption of the principal olivary afferent fibers composing the central tegmental tract [ l , 2 1 , 341. Studies indicate a topographic relationship between a localized lesion in the cerebellar dentate nucleus and hypertrophy of a limited portion of the olivary nucleus [34,41]. The hypertrophy of the nucleus is associated with vacuolar changes of neurons and gliosis, appearing over a few months after the disruption of afferent fibers [ 1, 211.…”

Section: Oliva Ry Hypert Ropbymentioning

confidence: 99%

Palatal myoclonus and denervation supersensitivity in the central nervous system

Matsuo

Ajax

1979

Annals of Neurology

123

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We postulate that palatal myoclonus after infarction of the brainstem or cerebellum, or both, is the manifestation of denervation supersensitivity secondary to lesions involving the dentatorubroolivary system. Two cases of our own and 31 from the English and French literature were analyzed in order to determine the delay between the occurrence of presumed anatomical lesions and the recognition of palatal myoclonus. The intervals varied from 2 to 49 months with the median between 10 and 11 months. The natural history of palatal myoclonus following brainstem infarction seemed consistent with the hypothesis.

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Hypertrophy of the inferior olives

Cited by 56 publications

References 24 publications

Midbrain tremor and hypertrophic olivary degeneration after pontine hemorrhage

Midbrain tremor and hypertrophic olivary degeneration after pontine hemorrhage

Hypertrophic olivary degeneration in children: four new cases and a review of the literature with an emphasis on the MRI findings

Palatal myoclonus and denervation supersensitivity in the central nervous system

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