Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension

Shrivastav, Chanchal

doi:10.7860/jcdr/2016/17747.7394

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…In study by Chanchal S et al [7] mean serum uric acid level in group A (Essential Hypertension) was significantly higher than group B (normotensive cases) (6.56 ± 0.76, 4.91 ± 0.97 mg/dl, p<0.001 respectively). 37.33% of patients had hyperuricaemia in group A as compared to 14% in group B (p<0.01, OR=3.66) indicating that a hyperuricaemic individual has 3.66 times more risk of developing Essential Hypertension as compared to the one with lower value of serum uric acid.…”

Section: Discussionmentioning

confidence: 86%

“…Three recordings of blood pressure as systolic and diastolic blood pressure (SBP and DBP) has been taken after a minimum of 5 minutes of rest to avoid any possible effects of anxiety and with an interval of 5 minutes. Hypertension was defined as per JNC -7 classification of hypertension [7] . The venous blood samples were obtained after an overnight fasting (≥12hrs) for estimation of complete blood counts, renal function tests (Serum Urea, Serum Creatinine & Serum uric acid), Thyroid-stimulating hormone (TSH), random blood sugar and serum lipids: total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), The values were determined calorimetrically using commercially available diagnostic kits using an autoanalyser.…”

Section: Exclusion Criteriamentioning

confidence: 99%

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A study on association of serum uric acid in hypertensive patients

Baghyajyothi¹

2018

Int. J. Adv. Biochem. Res.

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Background: Uric acid is the end product of purine metabolism. Metabolic disorders of uric acid are associated with many disease states. Substantial evidence suggests the possible role of uric acid as a mediator of high blood pressure. Elevated uric acid is closely associated with new onset essential hypertension in adolescents and prehypertension; and urate-lowering agents can significantly improve these early stages of hypertension. Uric acid also influences salt sensitivity of blood pressure through two phases. Local renin-angiotensin-aldosterone system activation initiates renal damage, arteriolopathy, and endothelium dysfunction, which is followed by the dysregulation of sodium homeostasis, thereby leading to increased salt sensitivity. In this review we summarize the available evidence to contribute to a better understanding of the casual relationship between uric acid and early or intermediate stages of hypertension. We hope our review can contribute to the prevention of hypertension or provide new insights into a treatment that would slow the progression of hypertension.

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Section: Discussionmentioning

confidence: 86%

Section: Exclusion Criteriamentioning

confidence: 99%

A study on association of serum uric acid in hypertensive patients

Baghyajyothi¹

2018

Int. J. Adv. Biochem. Res.

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“…15 In this study, the prevalence of HU was lower in subjects with T2DM (5.63%) and HTN (4.25%) in comparison to earlier reports wherein 25% of T2DM subjects35 and 26%-56% HTN subjects had reported HU. [36][37][38][39] The lower HU prevalence among our T2DM and HTN subjects as compared to other studies could be possibly attributed to the higher diagnostic cut off for SUA level or variability in the diagnosis procedure. In this study, subjects with SUA levels >7 mg/dL were considered as hyperuricemic, while some trial defined HUA as UA greater than 7 mg/dL in males and greater than 6 mg/dL in females.…”

Section: Discussionmentioning

confidence: 94%

“…14 Few studies have documented a higher prevalence of HU in patients with type 2 Diabetes Mellitus (T2DM) (25.35%), metabolic syndrome (47.1%), obesity (44.6%) and Hypertension (HTN) (37.33%) as compared to 14% prevalence in healthy normotensive individuals, suggesting HU to be a significant and independent risk factor for CVD, cerebrovascular diseases, HTN and T2DM. [15][16][17] Hyperinsulinemia in T2DM decreases renal excretion, increases renal re-absorption and the production of UA. 18 The presence of HTN, CVD or CKD in patients with asymptomatic HU have an increased risk of urate deposition.…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia prevalence in Indian subjects with underlying comorbidities of hypertension and/or type 2 diabetes: a retrospective study from subjects attending hyperuricemia screening camps

Patel

Shah

2020

Int J Res Med Sci

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Background: To determine the prevalence of HU in Indian subjects attending the HU screening camps and in subjects with type 2 Diabetes Mellitus (T2DM), Hypertension (HTN), and T2DM+HTN.Methods: This was a retrospective, non-interventional study where medical records of subjects attending HU screening camps across 592 locations in India, between June 2017 to May 2018, were analyzed.Results: A total of 197097 subjects (T2DM: 19.69%; HTN: 14.08%; T2DM+HTN: 21.60%) attended the screening camps. Mean age of the study participants was 48.43±13.38 years (Male: 53.80%). A total of 48606(24.66%) subjects had HU. In the overall population, a higher proportion of subjects with T2DM + HTN (7.36%) had HU in comparison to subjects with T2DM (5.63%) and HTN (4.25%) alone. Similar results were reported when the data was evaluated only in HU subjects (T2DM+HTN: 29.85%; T2DM: 22.82%; HTN: 17.22%). Proportion of HU subjects increased with age, with the maximum prevalence evident in subjects aged >50 years (12.94%), followed by 30-50 years (10.65%) and <30 years (1.07%). Gender-wise, a slightly higher proportion of males (14.13%) were found to be hyperuricemic than females (10.53%). Higher proportion of subjects with disease (T2DM and/or HTN) duration of 2-5 years were found to be hyperuricemic in comparison with subjects with disease duration of >5 years or <2 years. Similar results were reported when the data was evaluated in the overall HU subjects and by indication.Conclusions: Authors observed a high prevalence of HU among subjects attending HU camps and those with associated comorbidities. The prevalence of HU was higher in males and has an increasing trend with age. Furthermore, the prevalence of HU was observed to be higher in subjects with 2-5 years of duration of T2DM and/or HTN.

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“…In the Kingdom of Saudi Arabia (KSA), about 27.1% of Saudi individuals suffer from both HTN and hyperuricemia, and the latter could be symptomatic or asymptomatic (10) . Mean uric acid ranges have been reported, and the frequency of hyperuricemia is significantly higher in hypertensive patients in comparison to healthy people (11) .…”

Section: Introductionmentioning

confidence: 99%

Does Hypertension Contribute to Eliciting Gout Symptoms in Hyperuricemic Patients?

2023

The Egyptian Journal of Hospital Medicine

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Background and objective: Treatment of gout flares with uric acid-lowering medications is not optimal in hypertensive hyperuricemic patients and only sedates gout symptoms. The current study aimed to explore whether blood pressure control (BP) determines the symptomatic or asymptomatic status of hyperuricemic patients with elevated blood pressure. Patients and Methods: A cross-sectional study was conducted with 211 hypertensive hyperuricemic participants obtained from the King Saud Medical City (KSMC). All patients were categorized into three blood pressure groups: controlled, uncontrolled, and untreated hypertension groups. Based on uric acid (UA) levels, the participants were divided into three UA tertiles: T1, <157 µmol/L, T2:157-360 µmol/L and T3:>360 µmol/L. Descriptive statistics of the study variables and multivariate regression analysis were utilized to determine the association between gout joint flares and blood pressure after adjustment of the risk factors. Results:The findings revealed an increased prevalence of gout symptoms across the three BP groups. Moreover, this association was significant even after adjustment of the age, gender, BMI, and smoking. Also, there was a significant goutsymptoms difference when comparing the corresponding UA tertiles in each blood pressure group. Moreover, a significant positive association existed between blood pressure and the frequency and number of gouty attacks. The more controlled blood pressure, the less frequent and short-duration attacks. Conclusion: Hypertension was strongly suggested as a major risk factor in eliciting gout symptoms in hyperuricemic patients, whatever is the level of serum uric acid.

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Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension

Cited by 4 publications

References 14 publications

A study on association of serum uric acid in hypertensive patients

A study on association of serum uric acid in hypertensive patients

Hyperuricemia prevalence in Indian subjects with underlying comorbidities of hypertension and/or type 2 diabetes: a retrospective study from subjects attending hyperuricemia screening camps

Does Hypertension Contribute to Eliciting Gout Symptoms in Hyperuricemic Patients?

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