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INTRODUCTIONLife is not merely to be alive, but to be healthy and wealthy. Despite incredible improvement in health since 1950, cardiovascular disease remains among the leading causes of death worldwide. Hypertension (HT) is the most common risk factor for cardiovascular morbidity and mortality. This positive relationship between blood pressure (BP) and cardiovascular risk has been shown to exist not only in those with higher BP but also in individuals with high-normal BP/prehypertension. 1 Prehypertension as the name suggests that it precedes the hypertension. Trends in hypertension prevalence in India have shown a high prevalence of hypertension in both urban and rural areas. The prevalence rates of hypertension among urban population are 36.4% and rural people are 21.2%. 2 ABSTRACTBackground: Hypertension is one of the current emerging community health problems, which is very common affecting one in four individuals. Hyperuricemia is predictive for the development of both hypertension and coronary artery disease. Since there are various etiological factors associated with hypertension so it is very difficult to predict which one is the most common cause of hypertension. Little or no information is present in the population of Rajasthan, on the association between serum uric acid and essential hypertension. Hence this study is carried out to investigate the existence of an association between serum uric acid and essential hypertension. Methods: In this hospital based case control study, a total of 75 newly diagnosed essential hypertensive cases, 75 prehypertensive cases and 50 normotensive healthy controls, aged 20-50 years of both sexes were enrolled after excluding gout, diabetes mellitus, cardiovascular diseases, renal diseases, metabolic syndrome, secondary hypertension or history of having relevant drugs by taking detailed history and physical examination. Serum uric acid was measured in all study cases as well as control subjects. Results:The results of our study revealed that the mean serum uric acid level and the frequency of subjects with increased serum uric acid level were significantly higher in newly diagnosed cases of essential hypertension as compared to prehypertensive and normotensive controls (p< 0.001). Serum uric acid correlated positively with systolic blood pressure (SBP) (r= + 0.23, p<0.05) and diastolic blood pressure (DBP) (r= + 0.09, p>0.05). These results indicate a definite association between hyperuricaemia and essential hypertension. Conclusions: In the present study, Elevated level of SUA is significantly linked with PreHT and EHT after controlling various confounding factors. The present study showed that the number of hyperuricaemic individuals and mean SUA level were significantly higher in newly diagnosed cases of hypertension as compared to prehypertensive and normotensive control.

Background: Hypertension is most commonly documented modifiable risk factor for cardiovascular diseases. A growing body of data proposes an appreciated pathogenic role of an elevated serum uric acid in atherosclerosis and cardiovascular disease (CVD). Increased oxidative stress could be involved in the pathogenesis of hypertension. Oxidative stress marker, serum uric acid (SUA) and serum malondialdyhyde level (S. MDA) are affected by both genetic and environmental factors and related to biological factors as gender, age and body mass. So, the aim of the study is to access the association of body mass index (BMI) with oxidative stress parameters in essential hypertension (EHT).Methods: For the said purpose, this case control study was carried out on a total of 200, age and sex matched 75 hypertensives, 75 prehypertensive and 50 healthy subjects. After diagnosis of cases, SUA was estimated by standard kit method and S. MDA was estimated manually by Buege and Aust method.Results: This study represents that systolic and diastolic blood pressure were increased with increased BMI in all groups. Oxidative stress marker, SUA and S. MDA level increased significantly with increasing BMI in all groups and were positively correlated.Conclusions: Our study indicates that monitoring of the blood pressure, SUA and S. MDA at regular interval and maintaining of the oxidative balance would be helpful in preventing the development of hypertension and associated cardio-vascular morbidities.

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