Hyperuricemia as an independent risk factor for major cardiovascular events

Capuano, Vincenzo; Marchese, Federica; Capuano, Rocco; Torre, Sergio; Iannone, Anna; Capuano, Eduardo; Lamaida, Norman; Sonderegger, Matteo; Capuano, Ernesto

doi:10.2459/jcm.0000000000000347

Cited by 32 publications

(24 citation statements)

References 51 publications

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“…Confounder-adjusted stepwise linear regression revealed SUA, age, creatinine, glucose, and systolic blood pressure as independent predictors of MACE. Diastolic blood pressure and creatinine were independently correlated with SUA in the entire population, diastolic blood pressure only in men, and BMI, creatinine, age, and C3 in women 30 .…”

Section: Recent Advancesmentioning

confidence: 86%

“…Hyperuricemia was shown to be a strong independent risk factor for major cardiovascular events (MACE) in a study that collected baseline clinical data through a 1998/1999 longitudinal survey as part of the Valle dell'Irno Prevenzione Project, and evaluated MACE incidence after 10 years 30 . A total of 1,175 patients (aged 25-74 years, 50% men) completed the study.…”

Section: Recent Advancesmentioning

confidence: 99%

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The problem of cardio-renal diseases in patients with gout

Ferri

2017

Current Medical Research and Opinion

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Backgrounds: Although evidence is mounting on the role of hyperuricemia in cardio-renal disease, continuing doubt remains as to whether hyperuricemia can be considered a major causal cardiovascular risk factor. In addition, available data suggest that treatment may be beneficial, even in the absence of overt gout, when hyperuricemia accompanies other clinical conditions, such as urate deposition, advanced chronic kidney disease, or cardiovascular risk factors. Methods and Results: Analysis of the literature suggests there would be sufficient evidence warranting clinical trials to determine whether lowering uric acid levels would be clinically beneficial in the prevention or treatment of cardiovascular and renal diseases. Conclusion: Under a practical profile, it becomes progressively more important to investigate the possibility of reducing serum uric acid levels in the general population below the level of 5.0 mg/dL.

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Section: Recent Advancesmentioning

confidence: 86%

Section: Recent Advancesmentioning

confidence: 99%

The problem of cardio-renal diseases in patients with gout

Ferri

2017

Current Medical Research and Opinion

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“…Hyperuricemia is an illness caused by increased concentration of serum uric acid (> 420 μmol/l in men and > 358 μmol/l in premenopausal women) [14,15]. Gout is the most common inflammatory arthritis caused by the formation and deposition of monosodium urate (MSU) crystals among hyperuricemia patients [16].…”

Section: Introductionmentioning

confidence: 99%

Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

Wang

et al. 2019

Horm Metab Res

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The risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which included 115 gout patients, 439 hyperuricemic patients, and 2 254 individuals without gout and hyperuricemia. A systematic review and meta-analysis of 14 observational studies was also done to systematically evaluate the risk of thyroid dysfunction among patients with gout and hyperuricemia. Findings from the cross-sectional study suggested a significantly increased risk of hypothyroidism among female gout patients (OR=2.44, 95% CI 1.15–5.17, p=0.02). Besides, gout could also substantially increase risk of Hashimoto’s thyroiditis in women (OR=3.15, 95% CI 1.53–6.49, p=0.002). The meta-analysis proved a considerably increased risk of hypothyroidism among both gout patients (OR=1.51, 95% CI 1.23–1.85, p<0.001) and hyperuricemic patients (OR=1.34, 95% CI 1.11–1.61, p=0.002). Moreover, this meta-analysis also suggested that gout could also significantly increase the risk of hyperthyroidism (OR=1.25, 95% CI 1.06–1.48, p=0.01). The findings from the study suggest increasing risk of hypothyroidism and Hashimoto’s thyroiditis among gout patients. Moreover, gout but not hyperuricemia is linked to increased risk of hyperthyroidism. More studies are warranted to elucidate the influence of gout and hyperuricemia on thyroid disorders.

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“…Recent studies have shown that hyperuricemia increases the risk for cardiovascular diseases and mortality [1,2]. Chronic kidney disease (CKD) is also a risk for cardiovascular events and premature death [3].…”

Section: Introductionmentioning

confidence: 99%

Genetically Elevated Serum Uric Acid and Renal Function in an Apparently Healthy Population

Zhu

et al. 2019

Urol Int

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Background: The association between uric acid and kidney disease has been extensively investigated. Numerous studies have reported the association between circulating levels of uric acid and renal function. Objectives: To test, by the Mendelian randomization method, whether there is a causal association between circulating levels of uric acid and renal function. Methods: In 989 participants, estimated glomerular filtration rate (eGFR) was calculated, the circulating level of uric acid was tested, and the uric acid polymorphism (rs11722228) was genotyped. Results: After adjusting for age, gender, smoking history, alcohol intake, antihypertensive medication, body mass index, waist-to-hip ratio, and levels of urea nitrogen and creatinine, a significant allelic difference was found in uric acid levels for each genotype (p < 0.0001). Furthermore, the circulating levels of uric acid were negatively associated with eGFR after adjusting for cardiovascular risk factors and other potential confounders (p < 0.0001). Meanwhile, eGFR was significantly associated with the genotypes of rs11722228 (β = -0.07; p = 0.02). Conclu-sions: Evidence from the Mendelian randomization approach implied a causal relationship between uric acid and renal function in an apparently healthy population.

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Hyperuricemia as an independent risk factor for major cardiovascular events

Abstract: Hyperuricemia was shown to be a strong independent risk factor for MACE and should be included in cardiovascular prevention strategies. Whether hypouricemic drugs can decrease cardiovascular disease risk warrants further studies.

Cited by 32 publications

References 51 publications

The problem of cardio-renal diseases in patients with gout

The problem of cardio-renal diseases in patients with gout

Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

Genetically Elevated Serum Uric Acid and Renal Function in an Apparently Healthy Population

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