Hyperuricemia in Severe Pulmonary Hypertension

Voelkel, Marc A.; Wynne, Kristine; Badesch, David B.; Groves, Bertron Μ.; Voelkel, Norbert F.

doi:10.1378/chest.117.1.19

Cited by 114 publications

(80 citation statements)

References 18 publications

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“…In their study, serum UA levels were independently related to survival, but subsequent analysis of receiver operating characteristic curves did not demonstrate substantial predictive power. Voelkel, et al 20) demonstrated a positive correlation between pulmonary artery pressure and serum UA levels in a study of 92 patients with secondary pulmonary hypertension (connective tissue disease, n = 23). However, their study did not address the relationship between serum UA levels and prognosis.…”

Section: Discussionmentioning

confidence: 96%

Serum Uric Acid as a Prognostic Predictor in Pulmonary Arterial Hypertension With Connective Tissue Disease

et al. 2007

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SUMMARYBackground: Pulmonary arterial hypertension (PAH) has been identified as a life threatening complication of connective tissue disease. However, the association between serum uric acid (UA) levels and long-term outcome in PAH with connective tissue disease has not been evaluated. We therefore assessed whether serum UA levels are related to the mortality of such patients. Methods and results:We investigated 90 consecutive patients with connective tissue disease who were initially diagnosed with PAH by echocardiography, and assessed the long-term clinical outcome in populations with higher (≥ 4.7 mg/dL) and lower serum UA levels. Kaplan-Meier analysis showed that patients with higher median serum UA values had a significantly worse survival rate for any cause of death (54.5% versus 84.7%, logrank, P < 0.01) and PAH-related death (72.7% versus 93.4%, log-rank, P < 0.01) than those with low values. Multivariate analysis showed that an elevated serum UA level was an independent predictor for survival (hazard ratio, 1.88, 95% CI [1.24-2.84], P < 0.01). Conclusion:Elevated serum UA levels are associated with a poor prognosis and can serve as a prognostic predictor for patients with PAH secondary to connective tissue disease. (Int Heart J 2007; 48: 523-532)

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Section: Discussionmentioning

confidence: 96%

Serum Uric Acid as a Prognostic Predictor in Pulmonary Arterial Hypertension With Connective Tissue Disease

et al. 2007

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“…High uric acid levels were found to relate to poor survival in patients with IPAH [86]. However, allopurinol is often prescribed to patients with PAH, and hyperuricaemia and diuretics influence its plasma levels, impairing the value of clinical monitoring based on uric acid levels.…”

Section: Biochemical Markersmentioning

confidence: 99%

Guidelines for the diagnosis and treatment of pulmonary hypertension

Galiè¹,

Hoeper²,

Humbert³

et al. 2012

Revista Portuguesa de Cardiologia (English Edition)

419

738

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“…Elevated uric acid levels have long been known to be a poor prognostic sign in acute illness [51]. Several studies have demonstrated that an elevated urate level in PH correlates with severity of disease [52][53][54][55][56]. In one study, 90 patients with IPAH underwent right heart catheterisation and serum uric acid estimation, and were then followed for a mean of 31 months [54].…”

Section: Uric Acidmentioning

confidence: 99%

Biomarkers in pulmonary hypertension

Warwick

Thomas²,

Yates³

2008

Eur Respir J

140

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There have been significant recent advances in the understanding of the pathophysiology of pulmonary hypertension, and a growing number of therapeutic agents have become available to the treating physician. Traditional methods of diagnosing and monitoring this condition have comprised echocardiography and right heart catheterisation, in addition to functional measures, such as estimation of functional class and the 6-min walk test. An increasing number of biomarkers have been described that are elevated in pulmonary hypertension and which may assist the clinician in diagnosis and in the assessment of disease severity and response to treatment.The present article details the more important biomarkers, their potential applications and the evidence supporting their use.

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Hyperuricemia in Severe Pulmonary Hypertension

Cited by 114 publications

References 18 publications

Serum Uric Acid as a Prognostic Predictor in Pulmonary Arterial Hypertension With Connective Tissue Disease

Serum Uric Acid as a Prognostic Predictor in Pulmonary Arterial Hypertension With Connective Tissue Disease

Guidelines for the diagnosis and treatment of pulmonary hypertension

Biomarkers in pulmonary hypertension

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