Hypervascular Metastatic Cardiac Tumors: An Unknown Cause of Mitral Valve Prolapse.

Abstract

A 40-yr-old woman with alveolar soft-part sarcoma and multiple hypervascular cardiac tumors involving both left and right ventricles is reported. Papillary muscle dysfunction and mitral valve prolapse with mitral regurgitation were caused by the largest tumor in the left ventricle. (Internal Medicine 31: 78-81, 1992)

Cryoablation Combined with Iodine-125 Implantation in the Treatment of Cardiac Metastasis from Alveolar Soft Part Sarcoma: A Case Report

“…It predominantly affects adolescents and young adults, and the most common primary sites are the lower extremities, frequently the thigh [14] . ASPS is often asymptomatic and is sometimes only detected after long disease-free intervals; cardiac metastases from ASPS are rare [4,5] . In advanced forms of cardiac metastases, tumor growth is frequently accompanied by bloody exudate in the pericardial sac, which may result in a life-threatening tamponade.…”

“…It often originates in the muscle and deep soft tissues of the extremities, but it has also been found in organs without skeletal muscle, such as the lungs, breasts, stomach, bone, and the female genital organs [2,3] . The most common sites of metastases are the lung (38%), brain (33%), and bone (33%) [4] , and cardiac metastases from ASPS are rare [5] . ASPS is an indolent disease with characteristically slow growth, but it is associated with poor overall outcome and a 5-year survival rate of only 20% in unresectable metastatic patients [6,7] .…”

Alveolar soft part sarcoma in brain with cardiac metastasis

“…The common sites of metastasis are lung (38%), bone (33%), and brain (33%) [3]. An association between ASPS and cardiac metastasis is very International Journal of Cardiology 114 (2007) e93 -e95 www.elsevier.com/locate/ijcard rare [4]. Local recurrences have been reported to occur in up to 20% of patients with ASPS.…”

Giant Metastatic Alveolar Soft Part Sarcoma in the Left Ventricle: Appearance in Echocardiography, Magnetic Resonance Imaging, and Histopathology

“…3,4 The common sites of metastasis are lung, bone, and brain. 5 The coexistence of ASPS and cardiac metastasis is very rare 6 ; however, because ASPS might metastasize to the heart and induce severe heart failure, a cardiac examination should be performed in patients with ASPS. Clinical symptoms of these cardiac tumors could be absent or nonspecific, so their diagnosis and treatment may be delayed.…”