Hypervirulent and hypermucoviscous extended-spectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> and <i>Klebsiella variicola</i> in Chile

Morales-León, Felipe; Opazo-Capurro, Andrés; Caro, C.; Lincopán, Nilton; Cardenas-Arias, Adriana; Esposito, Fernanda; Illesca, Vijna; Rioseco, María Luisa; Domínguez-Yévenes, Mariana; Lima, Celia A.; Bello-Toledo, Helia; González-Rocha, Gerardo

doi:10.1080/21505594.2020.1859274

Cited by 26 publications

(22 citation statements)

References 52 publications

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“…Previous studies have pointed out that K. variicola was first identified as a new bacterial strain in 2004 ( Rosenblueth et al., 2004 ). As one of the subspecies within the Klebsiella pneumoniae complex, K. variicola has received much attention recently for their hypermucoviscosity and hypervirulence ( Rodríguez-Medina et al., 2019 ; Morales-León and Opazo-Capurro, 2021 ; Nakamura-Silva et al., 2021 ). Recently research also found that the K. variicola strains have potential capacity to colonize in different tissues and cause infection ( de Campos et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock

Chen

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveSepsis-induced myocardial dysfunction (SIMD) seriously affects the evolution and prognosis of the sepsis patient. The gut microbiota has been confirmed to play an important role in sepsis or cardiovascular diseases, but the changes and roles of the gut microbiota in SIMD have not been reported yet. This study aims to assess the compositions of the gut microbiota in sepsis or septic patients with or without myocardial injury and to find the relationship between the gut microbiota and SIMD.MethodsThe prospective, observational, and 1:1 matched case–control study was conducted to observe gut microbiota profiles from patients with SIMD (n = 18) and matched non-SIMD (NSIMD) patients (n = 18) by 16S rRNA gene sequencing. Then the relationship between the relative abundance of microbial taxa and clinical indicators and clinical outcomes related to SIMD was analyzed. The receiver operating characteristic (ROC) curves were used to evaluate the predictive efficiencies of the varied gut microbiota to SIMD.ResultsSIMD was associated with poor outcomes in sepsis patients. The beta-diversity of the gut microbiota was significantly different between the SIMD patients and NSIMD subjects. The gut microbiota profiles in different levels significantly differed between the two groups. Additionally, the abundance of some microbes (Klebsiella variicola, Enterobacteriaceae, and Bacteroides vulgatus) was correlated with clinical indicators and clinical outcomes. Notably, ROC analysis indicated that K. variicola may be a potential biomarker of SIMD.ConclusionOur study indicates that SIMD patients may have a particular gut microbiota signature and that the gut microbiota might be a potential diagnostic marker for evaluating the risk of developing SIMD.

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Section: Discussionmentioning

confidence: 99%

Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock

Chen

Zhang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…These data are consistent with the view that strains carrying high levels of resistance to antibiotics are not hypervirulent, and vice versa, presumably, because there is a trade-off, due the burden of carrying different genetic determinants. Notwithstanding this, the emerging acquisition of multidrug resistant by hv K. pneumoniae is particularly concerning [ 1 , 2 , 3 , 55 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt

et al. 2021

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Klebsiella pneumoniae is an important human pathogen in both developing and industrialised countries that can causes a variety of human infections, such as pneumonia, urinary tract infections and bacteremia. Like many Gram-negative bacteria, it is becoming resistant to many frontline antibiotics, such as carbapenem and cephalosporin antibiotics. In Egypt, K. pneumoniae is increasingly recognised as an emerging pathogen, with high levels of antibiotic resistance. However, few Egyptian K. pneumoniae strains have been sequenced and characterised. Hence, here, we present the genome sequence of a multidrug resistant K. pneumoniae strain, KPE16, which was isolated from a child in Assiut, Egypt. We report that it carries multiple antimicrobial resistance genes, including a blaNDM-1 carbapenemase and extended spectrum β-lactamase genes (i.e., blaSHV-40, blaTEM-1B, blaOXA-9 and blaCTX-M-15). By comparing this strain with other Egyptian isolates, we identified common plasmids, resistance genes and virulence determinants. Our analysis suggests that some of the resistance plasmids that we have identified are circulating in K. pneumoniae strains in Egypt, and are likely a source of antibiotic resistance throughout the world.

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“… K. variicola isolates generally display lower antibiotic resistance rates than K. pneumoniae ( 4 ). Although being increasingly reported worldwide, K. variicola as an infectious agent in humans is poorly studied ( 5 – 8 ).…”

Section: Observationmentioning

confidence: 99%

Genetic Characteristics and Microbiological Profile of Hypermucoviscous Multidrug-Resistant Klebsiella variicola Coproducing IMP-4 and NDM-1 Carbapenemases

et al. 2022

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Hypervirulent and hypermucoviscous extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Klebsiella variicola in Chile

Cited by 26 publications

References 52 publications

Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock

Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock

Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt

Genetic Characteristics and Microbiological Profile of Hypermucoviscous Multidrug-Resistant Klebsiella variicola Coproducing IMP-4 and NDM-1 Carbapenemases

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