Hyperviscosity syndrome in multiple myeloma

Kopp, William L.; Beirne, Gregory J.; Burns, Robert O.

doi:10.1016/0002-9343(67)90156-8

Cited by 56 publications

(9 citation statements)

References 6 publications

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“…The hyperviscosity syndrome encom passes a variety of manifestations attributed to an elevated blood viscosity, mucosal hem orrhages and renal impairment [4][5][6]. In our case, as we did not think of multiple myelo ma at first, severe epistaxis and petechiae that began acutely during the 4th day of hemodialysis were attributed to heparin overdose.…”

mentioning

confidence: 68%

“…Renal failure, the most important clinical manifestation of myeloma kidney, was once a particularly common cause of death in patients with multiple myeloma. Although renal failure remains a common problem in these patients, it is now clear that myeloma-related renal failure can often be reversed and that extended survival is possi ble, even in patients with irreversible renal failure, as long as the systemic features of the neoplastic process can be controlled [4][5][6]. Patients with multiple myeloma associated with high titer serum paraproteins can mani fest unique hemostatic disorders.…”

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confidence: 99%

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Thrombocytopenia with a Myeloma Kidney

Kayhan¹,

Aki²,

Sindel³

et al. 1997

Nephron

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confidence: 68%

mentioning

confidence: 99%

Thrombocytopenia with a Myeloma Kidney

Kayhan¹,

Aki²,

Sindel³

et al. 1997

Nephron

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“…Subsequent physicochemical studies on the myeloma protein of one of the two patients showed a sedimentation constant of 13.2S, a molecular weight of about 808,000, and an intrinsic viscosity of 9.5 cc/g (20). In two subsequent reports of the hyperviscosity syndrome in IgG myeloma, aggregation of the 7S myeloma globulin could not be demonstrated (21,22).…”

Section: Discussionmentioning

confidence: 89%

The hyperviscosity syndrome

MacKenzie¹,

Fudenberg²,

O’Reilly³

1970

J. Clin. Invest.

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A B S T R A C T The hyperviscosity syndrome is an uncommon complication in IgG myeloma. Its occurrence has been ascribed to the presence in the serum of high molecular weight polymers of the IgG proteins. Three patients with IgG myeloma and the clinical hyperviscosity syndrome were investigated, none of whom had IgG polymers in the serum by analytical ultracentrifugation. Relative serum viscosity in these patients ranged from 10 to 17.4 (normal 1.4-1.8). The total serum proteins ranged from 14 to 19 g/100 ml of which 10 to 17 g/100 ml was IgG globulin. Physicochemical studies of two of the isolated myeloma proteins indicated that they were of normal molecular weight (near 158,000 and 162,-000). Protein Ca had a normal molecular radius (52.2 A) and configuration, (intrinsic viscosity of 5.5 cc/g, frictional ratio 1.48), but

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“…Reduced ability to concentrate and dilute the urine has been documented in man with HVS (Kopp, Beirne & Burns, 1967). Urine concentrating ability in the dog has been shown to be impaired when aerobic metabolism is inhibited (Weinstein, Manitius & Epstein, 1969), and the concentrating defects seen in HVS may be related to renal hypoperfusion and resultant decreased oxygen delivery to cells involved in sodium, and hence water, reabsorption.…”

Section: Renal Changesmentioning

confidence: 99%

Hyperviscosity syndrome with IgM monoclonal gammopathy and hepatic plasmacytoid lymphosarcoma in a cat

Williams

Goldschmidt

1982

J of Small Animal Practice

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A 19‐month‐old cat investigated because of depression, anorexia, polyuria, and polydipsia was found to have hepatomegaly, retinal haemorrhages, and distended tortuous retinal veins. Prolonged bleeding occurred after venipuncture, and serum was hyperviscous due to an immunoglobulin M monoclonal gammopathy. Prothrombin and activated partial thromboplastin times were prolonged, thrombin clotting time was only slightly prolonged and the activities of coagulation factors VII, VIII and IX were normal. The cat died suddenly before the origin of the immunoglobulin could be determined. Hepatic plasmacytoid lymphosarcoma was found at post‐mortem examination. The pathophysiology of hyperviscosity syndrome is discussed and the observations in this cat are compared with those reported in the dog.

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Hyperviscosity syndrome in multiple myeloma

Cited by 56 publications

References 6 publications

Thrombocytopenia with a Myeloma Kidney

Thrombocytopenia with a Myeloma Kidney

The hyperviscosity syndrome

Hyperviscosity syndrome with IgM monoclonal gammopathy and hepatic plasmacytoid lymphosarcoma in a cat

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