Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase.

Alex, Lisa A.; Borkovich, Katherine A.; Simon, Melvin I.

doi:10.1073/pnas.93.8.3416

Cited by 205 publications

(95 citation statements)

References 25 publications

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“…In N. crassa, for instance, a mutant of Nik1/ Os-1 exhibits hyper-osmosensitivity. 6,16) Similarly, it has been reported that RRG-1 (an SskA ortholog) is involved in the osmotic stress response, 24) while a mutant of RRG-2 (an SrrA ortholog) exhibits no sensitivity to high osmotic conditions. 25) In the case of C. heterostrophus, Dic1 is responsible for osmotic adaptation, and the deletion mutants of RRs (Áchssk1 and Áchskn7) show moderate sensitivity to osmotic stress.…”

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confidence: 99%

“…4) Such His-Asp phosphorelay systems have been identified and characterized in many fungi. [5][6][7][8][9][10] We have characterized the His-Asp phosphorelay system in Aspergillus nidulans. 11,12) For this model fungus, we have compiled a list of His-Asp phosphorelay components, containing 15 HKs, 4 RRs, and 1 HPt.…”

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confidence: 99%

“…Analogously, HKs of other filamentous fungi were found to play a crucial role in the fungicidal effect. Those NikA orthologs are Nik1/ Os-1 (Neurospora crassa), 6,16) Hik1 (Magnaporthe grisea), 17) Bos1 (Botrytis cinerea), 18) Dic1 (Cochliobolus heterostrophus), 19) and AbNik1 (Alternaria brassicicola). 20,21) The C. heterostrophus RRs, ChSsk1 and ChSkn7 (SrrA ortholog), have also been reported to be responsible for the growth-inhibitory effects of fungicides.…”

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confidence: 99%

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Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development inAspergillus nidulans

Hagiwara

Mizuno

Abe

2009

Bioscience, Biotechnology, and Biochemistry

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Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development inAspergillus nidulans

Hagiwara

Mizuno

Abe

2009

Bioscience, Biotechnology, and Biochemistry

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“…Graminicola, C. heterostrophus and F. graminearum. [76][77][78][79][80][81][82][83][84][85][86][87][88][89] The A. alternata Hog1 (AaHog1), analogous to the yeast Hog1, has a distinct phosphorylation motif (TGY) required for the hyperosmolarity response. 5 AaHog1 also has a protein kinase ATP-binding region, a MAP kinase and a serine/threonine protein kinase active site.…”

Section: The Cell Wall Integrity-mediated Signaling Pathway In a Altmentioning

confidence: 99%

Mitogen-activated protein kinase signaling pathways of the tangerine pathotype of Alternaria alternata

Chung

2013

MAP Kinase

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Mitogen-activated protein kinase (MAPK)-mediated signaling pathways have been known to have important functions in eukaryotic organisms. The mechanisms by which the filamentous fungus Alternaria alternata senses and responds to environmental signals have begun to be elucidated. Available data indicate that A. alternata utilizes the Fus3, Hog1 and Slt2 MAPK-mediated signaling pathways, either separately or in a cooperative manner, for conidia formation, resistance to oxidative and osmotic stress, and pathogenesis to citrus. This review provides an overview of our current knowledge of MAPK signaling pathways, in conjunction with the two-component histidine kinase and the Skn7 response regulator, in the tangerine pathotype of A. alternata.

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“…28,29) The Neurospora os-1 gene encodes a two-component histidine kinase similar to the yeast osmosensor Sln1p. 30,31) The osmotic regulation mediated by histidine kinase Sln1p has been well characterized as a high osmolarity glycerol (HOG) pathway in Saccharomyces cerevisiae. 32) Both histidine kinases, Neurospora Os1p and Saccharomyces Sln1p, are hybrid kinase which has a sensor region, a histidine kinase catalytic domain, and a response regulator domain.…”

Section: Molecular Basis Of Dicarboximide Resistance In Filamentous Fmentioning

confidence: 99%

Recent Topics on Action Mechanisms of Fungicides

Yamaguchi

Fujimura

2005

J. Pestic. Sci.

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When the rice blast pathogen Magnaporthe oryzae recognizes J. Pestic. Sci., 30(2), 67-74 (2005) * To whom correspondence should be addressed. E-mail: yamaism@riken.jp © Pesticide Science Society of Japan Recent Topics on Action Mechanisms of FungicidesIsamu YAMAGUCHI* and Makoto FUJIMURA † Plant Science Center, Tsurumi, Yokohama,, Japan † Faculty of Life Science, University of Toyo, Itakura, Oura-gun, Gunma 374-0193, Japan (Received December 27, 2004) Plant diseases are damaging to crop production in a temperate and humid climate like that of Japan, which has resulted in the development of many excellent fungicides, but wide-spread use of site-specific fungicides can cause pathogens to develop resistance in the field. While all modern fungicides have been developed through extensive safety evaluation, there is deep public concern about their side effects on non-target organisms. Thus there is a growing interest in non-fungicidal disease-controlling agents since they are supposedly specific to target organisms and less likely to cause resistance. Review the surface characteristics of the host plants such as lipophilicity and hardness, its germinating hypha starts differentiating a special cell termed an appressorium to infect the plant. The formation of appressoria involves signal transduction and the expression of many genes. Then, appressorial cells mature by forming a layer of melanin on the innermost part of the cell wall, which affords high osmotic pressure generated inside the cell to penetrate the cuticle layer of the host plant. Thus if melanin biosynthesis is inhibited, the pathogen cannot exert its pathogenicity. In fact, melanin biosynthesis inhibitors (MBIs) are primarily not toxic to the vegetative growth of M. oryzae, but achieve outstanding control of the blast disease in vivo. Actually there are two types of melanin biosynthesis inhibitors; hydroxynaphthalene reductase inhibitors (MBI-R: fthalide, tricyclazole and pyroquilon) and scytalone dehydratase inhibitors (MBI-D: carpropamid, diclocymet and fenoxanil). The buff mutants of M. oryzae were shown to phenotypically resemble the MBI-R-treated wildtype strains and were essentially nonpathogenic to rice plant, which suggested that a melanin biosynthetic pathway is indispensable for the appressoria to obtain infectiosity. RIKEN 1)Carpropamid was developed as a novel potent controlling agent against the rice blast, 2) and enzyme kinetic data showed that carpropamid is a tight-binding competitive inhibitor of scytalone dehydratase (STD), a key enzyme in the biosynthesis of melanin. Its calculated Ki value was 140 pM, which is more than 10 5 times smaller than the Km for scytalone. 3,4) An X-ray analysis of the crystal structure of the STD complex with carpropamid identified interactions that determine the tight-binding 5) as shown in Fig. 1. Three types of interactions were considered important for the binding: (1) a strong hydrogen bond between N131 (Asn 131) and chlorine, (2) two hydrogen bonds mediated by water molecules (WTA) and (3) the i...

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Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase.

Cited by 205 publications

References 25 publications

Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development inAspergillus nidulans

Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development inAspergillus nidulans

Mitogen-activated protein kinase signaling pathways of the tangerine pathotype of Alternaria alternata

Recent Topics on Action Mechanisms of Fungicides

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