Hyphal Growth Patterns and Recurrence of Fungal Keratitis after Lamellar Keratoplasty

Xie, Liping; Zhai, Hualei; Shi, Weiyun; Zhao, Jing; Sun, Shuo; Zang, Xinjie

doi:10.1016/j.ophtha.2007.07.034

Cited by 45 publications

(25 citation statements)

References 9 publications

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“…Alternaria species are a relatively uncommon cause of keratitis, 10,14 and although most cases were previously associated with agricultural trauma, they have been increasingly reported as an opportunistic pathogen in corneal and refractive surgery. 1,3,4,6,8 Its presentation as a contact lensrelated infection is, however, unusual despite its association with contact lens spoilage and its propensity to invade various contact lens matrices.…”

Section: Discussionmentioning

confidence: 99%

Alternaria Keratitis: Clinical Presentation and Resolution With Topical Fluconazole or Intrastromal Voriconazole and Topical Caspofungin

2009

Cornea

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Alternaria keratitis has a varied clinical presentation and may present without macroscopic pigmentation. In vitro sensitivity testing may be helpful in directing therapy for Alternaria keratitis, but clinical response should be monitored as the primary endpoint. Response to natamycin was poor, but successful resolution with topical fluconazole or intrastromal voriconazole and topical caspofungin with preservation of good visual acuity was possible.

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Section: Discussionmentioning

confidence: 99%

Alternaria Keratitis: Clinical Presentation and Resolution With Topical Fluconazole or Intrastromal Voriconazole and Topical Caspofungin

2009

Cornea

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“…According to the histopathology of clinical and experimental fungal keratitis, different species behaved differently in corneas. 2,11,12,17 C. albicans hyphae were reported to traverse the corneal stroma vertically. In the current study, we observed that hyphae of both isogenic strains grew vertically to the stromal lamellae.…”

Section: Discussionmentioning

confidence: 99%

“…Horizontal pattern was determined when most hyphae grew at an angle <45 • to the plane of stromal lamellae, and vertical pattern was when the angle of most hyphae and the stromal lamellae was >45 • . 2,17 The entire corneal section from each infected cornea were blindly photographed with an exposure control unit (model DG-U1, Nikon) attached to the microscope. The final magnification of 150 allowed us to determine and mark the deepest point of individual hyphal penetration into corneas.…”

Section: In Vivomentioning

confidence: 99%

Retracted: Role of Extracellular Phospholipase B ofCandida albicansas a Virulent Factor in Experimental Keratomycosis

Xie

Dong

et al. 2009

Current Eye Research

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“…A deep penetration of the fungus in the cornea / eye, in turn, seems to go against the use of new transplant techniques such as lamellar keratoplasty for the treatment of fungal keratitis. Although lamellar keratoplasty will be described as an effective method for the treatment of fungal keratitis unresponsive to drug treatment (30)(31)(32) even in deep cases (31) , cases with deep infection seem more likely to recur after lamellar keratoplasty (33) . Shi et al show that partial lamellar keratoplasty is effective for fungal keratitis in which the infected injury lies in the middle or upper layers, especially when the corneal ulcer is quite widespread and non central (32) .…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of fungal keratitis treated with penetrating keratoplasty by means of histopathologic findings

Ximenes¹,

Vasconcelos²,

Monte³

2016

Revista Brasileira De Oftalmologia

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RESUMOObjetivo: Estudar, através do exame histopatológico, a epidemiologia de ceratites fúngicas tratadas com ceratoplastia penetrante terapêutica, enfatizando a presença de cirurgia ocular prévia. Métodos: Inicialmente, o estudo foi observacional e transversal de botões corneanos provenientes de ceratoplastia penetrante no período de 2006-2015 enviados para exame histopatológico ao banco de olhos do Hospital Geral de Fortaleza. Os tecidos foram corados com Hematoxilina-eosina, PAS ou Grocott, e examinados com microscópio óptico. Foram selecionados casos com diagnóstico histopatológico de ceratite fúngica. Após a selecão, realizamos revisão de prontuários buscando idade e sexo do paciente, data(s) do(s) transplante(s) por ceratite fúngica, diagnóstico clínico pré-cirúrgico, presença/tipo de cirurgias anteriores e/ou posteriores. Incluímos 62 botões corneanos de 55 pacientes. Resultados: A maioria dos pacientes era do sexo masculino. Apenas 7 (11,29%) casos tiveram recidiva da infecção tratada cirurgicamente. 10 (16,13%) casos possuíam cirurgia ocular prévia a ceratite fúngica tratada por transplante. Nenhum caso teve ceratite fúngica como diagnóstico clínico pré-cirúrgico. A principal forma de fungo no exame histopatológico foi forma leveduriforme isolada, seguida pela leveduriforme associada à filamentosa. O aspecto predominante da membrana de Descemet foi livre de fungos. Conclusão: Demonstramos o potencial curativo das ceratites fúngicas quando tratadas com ceratoplastia penetrante terapêutica e uma possível associação do fator cirurgia ocular prévia ao desenvolvimento dessas infecções. Características do exame histopatológico foram abordadas diferente de outros estudos que, em sua maioria, citam apenas o exame microbiológico. A dificuldade no diagnóstico clínico pré-cirúrgico foi ressaltada, o que pode ter contribuído com a evolução dos casos estudados para tratamento cirúrgico.Descritores: Ceratite/epidemiologia; Ceratite/patologia; Infecções oculares fúngicas; Ceratoplastia penetrante

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Hyphal Growth Patterns and Recurrence of Fungal Keratitis after Lamellar Keratoplasty

Cited by 45 publications

References 9 publications

Alternaria Keratitis: Clinical Presentation and Resolution With Topical Fluconazole or Intrastromal Voriconazole and Topical Caspofungin

Alternaria Keratitis: Clinical Presentation and Resolution With Topical Fluconazole or Intrastromal Voriconazole and Topical Caspofungin

Retracted: Role of Extracellular Phospholipase B ofCandida albicansas a Virulent Factor in Experimental Keratomycosis

Epidemiology of fungal keratitis treated with penetrating keratoplasty by means of histopathologic findings

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