Hypnotic effects and pharmacokinetics of a single bolus dose of propofol in Japanese macaques (Macaca fsucata fsucata)

Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata)

“…Two catheters were placed in each cephalic vein and 5 mg/kg of propofol (Propofol 1%; “F”, Fuji Pharma Co., Ltd, Toyama, Japan) was infused via a catheter at 360 mg/kg/h following infusion at 40 mg/kg/h for 10 min, 20 mg/kg/h for 10 min, and 15 mg/kg/h for 100 min. The dose regimen was chosen to maintain the predicted propofol plasma concentration (Cp) of 4 μg/mL using the population pharmacokinetic (PPK) model we developed previously (Miyabe‐Nishiwaki et al. , 2010).…”

“…Measured divided by predicted (measured/predicted) Cp vs. time was depicted to evaluate the previously developed PK model (Miyabe‐Nishiwaki et al. , 2010).…”

“…We applied the pharmacokinetic modeling described previously (Miyabe‐Nishiwaki et al. , 2010) using both previous and current datasets.…”

“…The objective of this study was to assess a population pharmacokinetic model for Japanese macaque ( Macaca fuscata fuscata ) (Miyabe‐Nishiwaki et al. , 2010) during a step‐down infusion.…”

Therapeutic Review: Propofol and Fospropofol

“…13,15,29,30,34 Conversely, no changes in heart rate are reported in red-eared sliders, common buzzards, spotted bamboo sharks (Chylloscyllium plagiosum), Japanese macaques (Macaca fsucata fsucata), loggerhead sea turtles, red-tailed hawks, or great horned owls. 20,25,27,28,35,36 Electrocardiogram abnormalities have been noted in chickens (Gallus domesticus), canvasbacks (Aythya valisineria), and dogs; however, their cause is unknown. 2,[37][38][39] The effects of propofol on blood pressure also appear to be species specific; a continuous rate infusion of propofol in squirrel monkeys (Saimiri sciureus) has been associated with hypotension, while no changes in blood pressure were reported in red-tailed hawks or great horned owls.…”