Hypo-Cholesterolemic and Hypoglycemic Effects of Orange Albedo Powder (Citrus Aurantium L.) on Male Albino Rats

Abstract

Abstract:The present study was conducted to evaluates the hypocholesterolemic and hypoglycemic effects of dietary Orange Albedo Powder (Citrus Aurantium L.) in the hypercholesterolemic albino rats, also to examine various oxidative stress-associated with some biochemical parameters. Thirty two male albino rats weighing 110 + 10 g were divided into four groups, the first group received the basal diet only and served as (negative control), the second group received the hypercholesterolemic diet and served as (positive control), the other two groups received hypercholesterolemic diet supplemented with 10%, 20% orange albedo powder respectively (OrAP) for six weeks spontanously. The obtained results revealed that the groups of rats which received diets supplemented with 10% and 20% OrAP were significantly decrease total lipid, total cholesterol, triglycerides, low density lipoprotein cholesterol, liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), when compared with positive control, also kidney functions were significantly improved. Body weight gain and food intake were significantly decreased when compared with positive control. The results indicate that the orange albedo is a good source of natural fiber. It could use in obese people for body loss, also serves to improve blood picture and to reduce the blood glucose level in hypercholesterolemic rats.

Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data

“…Neohesperidin significantly decreased fasting glucose, serum glucose, and glycosylated serum protein in mice. In addition, this compound significantly reduced serum triglycerides, total cholesterol, leptin level, and liver index; it inhibited lipid accumulation in the liver and decreased the size of epididymal adipocytes in the KK-Ay mice ( Osfor et al, 2013 ; Jia et al, 2015 ).…”

“…Neohesperidin significantly decreased fasting glucose, serum glucose, and glycosylated serum protein in mice. In addition, this compound significantly reduced serum triglycerides, total cholesterol, leptin level, and liver index; it inhibited lipid accumulation in the liver and decreased the size of epididymal adipocytes in the KK-Ay mice (Osfor et al, 2013;Jia et al, 2015). Some phenolic glycosides, including niazirin A, S-Methyl-N-{4-[(α-l-rhamnosyloxy)benzyl]}thiocarbamate, reduced blood glucose levels in STZ-induced diabetic mice and promoted the glucose consumption of IR cells (Wang F. et al, 2017).…”

Hypocholesterolemic Effects of Kenaf Seed Oil, Macroemulsion, and Nanoemulsion in High‐Cholesterol Diet Induced Rats

“…Simvastatin works by inhibits 3‐hydroxy‐3‐methylglutaryl‐CoA (HMG‐CoA) reductase, which is the enzyme that catalyzes the rate‐limiting step in cholesterol synthesis, thereby lowers the cholesterol concentration in the liver cells. It also enhances the LDL receptor (Osfor et al., ).…”

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

“…In this context, studies have investigated the effect of fruit and vegetable by-products on managing body weight in humans and animals. For example, Osforw et al [ 34 ] evaluated the hypocholesterolemic and hypoglycemic effects of dietary orange albedo flour ( Citrus Aurantium L.) in hypercholesterolemic rats for six weeks. The groups of animals that consumed a diet containing 10% and 20% orange albedo flour had a significantly reduced body weight compared to the control group.…”