Hypocholesterolemic Effects of Kenaf Seed Oil, Macroemulsion, and Nanoemulsion in High‐Cholesterol Diet Induced Rats

Cheong, Ai Mun; Koh, Jue Xi Jessica; Patrick, Nwabueze Okechukwu; Tan, Chin Ping; Nyam, Kar Lin

doi:10.1111/1750-3841.14038

Cited by 20 publications

(14 citation statements)

References 46 publications

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“…Compared with the rats in the negative control (NC), rats fed on a high‐cholesterol diet (HC) leads to a decreased level of HDL‐C and increased levels of TC, LDL‐C and TG at the baseline and final of the experiment. These results were in the same line as with those published data (Luo et al ., ; Cheong et al ., ). The HDL‐C level was significantly increased ( P < 0.05; 45% for HL, 77% for HH and 23% for HS) and the TG level was significantly reduced ( P < 0.05; 42% for HL, 58% for HH and 52% for HS) in the VAO‐ and simvastatin‐treated rats when compared with their respective baseline results.…”

Section: Resultsmentioning

confidence: 97%

“…The use of lipidsoluble bioactive phytochemicals such as phytosterols and MUFA in the treatment and management of hypercholesterolaemia have been well documented in the past studies (Lu et al, 2010;Schwingshackl & Hoffmann, 2012). These phytochemicals work as antioxidant and anti-inflammatory elements to prevent the development of oxidative stress-induced endothelial dysfunction and lipoproteins oxidation in hypercholesterolaemia (Okbi et al, 2014;Cheong et al, 2018).…”

Section: Lipid Profilementioning

confidence: 99%

“…Hypercholesterolaemia is a condition characterised by elevated levels of cholesterol and low-density lipoprotein cholesterol (LDL-C) in the blood (Bunnoy et al, 2015;Cheong et al, 2018). It is a chronic disease that shows asymptomatic for prolonged periods.…”

Section: Introductionmentioning

confidence: 99%

“…Hypercholesterolaemia stimulates oxidative stress and free radicals production, thereby promoting the development of hepatic injury and atherosclerosis (Cheong et al, 2018). The dietary factors contributing to the occurrence of this disease is high consumption of foods rich in cholesterol, saturated fat or trans-fat (Ministry of Health, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Tan

Chong

Hamzah

et al. 2018

Int J of Food Sci Tech

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Summary Hypercholesterolaemia is a chronic disease associated with the development of nonalcoholic fatty liver disease and atherosclerosis. This study aimed to investigate the hypocholesterolaemic and hepatoprotective effects of virgin avocado oil (VAO) using diet‐induced hypercholesterolaemia rats. Male Sprague Dawley rats were fed high‐cholesterol diet for 4 weeks to induce hypercholesterolaemia. After confirming the establishment of hypercholesterolaemia model, the VAO (450 and 900 mg kg−1 body weight per day) and simvastatin (10 mg kg−1 body weight per day) were given orally while maintaining the high‐cholesterol diet for another 4 weeks. Changes in anthropometric, lipid profile, liver biomarkers and liver histology were determined. At the end of the experiment, the serum low‐density lipoprotein cholesterol (LDL‐C) and triglyceride (TG) levels were significantly reduced, while the high‐density lipoprotein cholesterol (HDL‐C) level was significantly increased in high‐dose VAO‐ (900 mg kg−1 body weight per day) and simvastatin‐treated rats when compared with their respective baseline values. The liver damage index was also markedly reduced in all treated rats. Current findings demonstrated the potential hypocholesterolaemic and hepatoprotective benefits of VAO in the preclinical study.

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Section: Resultsmentioning

confidence: 97%

Section: Lipid Profilementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Tan

Chong

Hamzah

et al. 2018

Int J of Food Sci Tech

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“…The fatty acid composition of KSO is similar to cottonseed oil but KSO does not contain gossypol (a toxic phenolic pigment) that present in the cottonseed oil (Bhattacharjee, Singhal, & Tiwari, ; Mohamed, Bhardwaj, Hamama, & Webber, ). KSO has been reported to have anticancer, anti‐inflammation, antiulcer, and antihypercholesterolemic properties (Cheong, Jessica Koh, Patrick, Tan, & Nyam, ; Ng et al., ; Nyam, Sin, & Kamariah, ; Nyam, Tang, & Long, ; Wong, Tan, Tan, Long, & Nyam, ) . However, the applications of KSO in food and nutraceutical industries are limited due to their poor stability and water solubility, hence leading to the poor bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Effect of Emulsification Method and Particle Size on the Rate of in vivo Oral Bioavailability of Kenaf (Hibiscus cannabinus L.) Seed Oil

Cheong

Tan

Nyam

2018

Journal of Food Science

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Kenaf (Hibiscus cannabinus L.) seed oil-in-water nanoemulsions stabilized by complexation of beta-cyclodextrin with sodium caseinate and Tween 20 have been shown to have higher bioaccessibility of vitamin E and total phenolic content than nonemulsified kenaf seed oil in the previous in vitro gastrointestinal digestion study. However, its oral bioavailability was unknown. Therefore, the aim of this study was to evaluate the rate of in vivo oral bioavailability of kenaf seed oil-in-water nanoemulsions in comparison with nonemulsified kenaf seed oil and kenaf seed oil macroemulsions during the 180 min of gastrointestinal digestion. Kenaf seed oil macroemulsions were produced by using conventional method. Kenaf seed oil-in-water nanoemulsions had shown improvement in the rate of absorption. At 180 min of digestion time, the total α-tocopherol bioavailability of kenaf seed oil nanoemulsions was increased by 1.7- and 1.4-fold, compared to kenaf seed oil and macroemulsion, respectively. Kenaf seed oil-in-water nanoemulsions were stable in considerably wide range of pH (>5 and <3), suggesting that it can be fortified into beverages within this pH range PRACTICAL APPLICATION: The production of kenaf seed oil-in-water nanoemulsions had provided a delivery system to encapsulate the kenaf seed oil, as well as enhanced the bioaccessibility and bioavailability of kenaf seed oil. Therefore, kenaf seed oil-in-water nanoemulsions exhibit a great potential application in nutraceutical fields.

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Hibiscus cannabinus

Shikha

Kashyap

Thakur

et al. 2023

Harvesting Food From Weeds

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Hypocholesterolemic Effects of Kenaf Seed Oil, Macroemulsion, and Nanoemulsion in High‐Cholesterol Diet Induced Rats

Cited by 20 publications

References 46 publications

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet‐induced hypercholesterolaemia rats

Effect of Emulsification Method and Particle Size on the Rate of in vivo Oral Bioavailability of Kenaf (Hibiscus cannabinus L.) Seed Oil

Hibiscus cannabinus

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