Hypocalcemia Reduces Rate of Disappearance of Glucose from Plasma

Schlumbohm, Christina; Harmeyer, J.

doi:10.1111/j.1439-0442.1990.tb00907.x

Cited by 8 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By this method, the glucose turnover will probably be underestimated, due to recycling of label in the course of the longer lasting experiment. In our own glucose clamp experiments carried out in piglets of the same strain and of the same age as those used here the estimated glucose turnover was two to three times higher (Schlumbohm & Harmeyer, 1990) than in this experiment. This demonstrates that the glucose turnover in growing pigs is subject to great variability and may quite markedly be influenced by the experimental conditions.…”

Section: Effect Of Hypocalcaemia On the Metabolism Of ª_bhbsupporting

confidence: 40%

“…One reason for this increase is possibly an increased lipomobilization in hypocalcaemic piglets brought about by a reduced insulin-mediated depression of lipolysis. It has been reported that hypocalcaemia not only reduces insulin secretion (Pento et al 1974) but also increases insulin resistance of peripheral tissues (Schlumbohm & Harmeyer, 1990). Both effects may enhance lipomobilization.…”

Section: Calculationsmentioning

confidence: 99%

“…Our own experiments with pigs (Schlumbohm & Harmeyer, 1990) and sheep (Schlumbohm et al 1997) have indicated that hypocalcaemia might be of significance in vivo for the control of glucose metabolism. A reduction of glucose turnover in the presence of hyperketonaemia has also been reported in humans (Baron et al 1989) and dogs (Shaw & Wolfe, 1984).…”

mentioning

confidence: 94%

See 2 more Smart Citations

Effect of Hypocalcaemia on Glucose Metabolism in Hyperketonaemic Piglets

Schlumbohm

Harmeyer

1999

Exp. Physiol.

Self Cite

View full text Add to dashboard Cite

In nine 2- to 3-month-old hyperketonaemic piglets the kinetics of glucose and D-beta-hydroxybutyrate (D-BHB) metabolism were studied during hypo- and normocalcaemia in paired experiments. Hyperketonaemia (1.3 and 2.5 mmol D-BHB (l plasma)-1) was generated by a stepwise increase of DL-BHB infusion. Hypocalcaemia spontaneously developed in five piglets due to an inherited calcitriol deficiency and was induced in four control piglets by a continuous infusion of Na2-EDTA. The method of single isotopic marker injections of glucose and D-BHB was used to calculate replacement rates, rate constants and half-lives of glucose and D-BHB in plasma. When DL-BHB was infused at the same rate into normo- and hypocalcaemic piglets, hypocalcaemia reduced the rate constant of glucose by 20-30% and the replacement rate of glucose by 34%. In the presence of hyperketonaemia, hypocalcaemia increased the rate of replacement of D-BHB by 6-40%. The replacement rate represents the sum of endogenous production and the rate of DL-BHB infusion. This observation shows that the endogenous production of D-BHB was higher during hypocalcaemia than during normocalcaemia.

show abstract

Section: Effect Of Hypocalcaemia On the Metabolism Of ª_bhbsupporting

confidence: 40%

Section: Calculationsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Hypocalcaemia on Glucose Metabolism in Hyperketonaemic Piglets

Schlumbohm

Harmeyer

1999

Exp. Physiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The increased risk of ketosis could not be attributed to differences in milk yield between normocalcemic and SCHC cows as milk production did not differ, thus the increased risk of ketosis observed herein and in other studies may be caused by mechanisms different than changes in milk production per se and are probably linked to alterations in glucose metabolism. For instance, Schlumbohm and Harmeyer (1990) reported that hypocalcemia induces a reduction of glucose utilization in pigs, which seems to be mediated by a decreased insulin secretion under low calcemia (Witzel and Littledike, 1973); however, whether this mechanism could be involved in ruminants is unknown.…”

Section: Resultsmentioning

confidence: 99%

Associations between subclinical hypocalcemia and postparturient diseases in dairy cows

Rodriguez

Arı́s

Bach

2017

Journal of Dairy Science

129

104

View full text Add to dashboard Cite

Dairy cows suffer blood Ca losses as lactation begins and might be affected by hypocalcemia in its clinical (total serum Ca concentration <1.50 mM) or subclinical form (total serum Ca concentration ≤2.14 mM). Several studies have suggested that hypocalcemia is associated with different health problems of the cow but results from different studies are not consistent. The objective of this study was to assess potential associations between subclinical hypocalcemia (SCHC) and displaced abomasum, intramammary infections, metritis, retained placenta, and ketosis. Also, the associations between SCHC and milk yield and reproductive function were evaluated. After discarding cows (32) with clinical hypocalcemia, a total of 764 cows from 6 different commercial farms were enrolled in this study. Blood samples were collected at 24 to 48 h postcalving and analyzed for total Ca concentration. Odds ratios of the different afflictions potentially associated with SCHC were calculated. Seventy-eight percent of the analyzed cows incurred SCHC. The occurrence of displaced abomasum, ketosis, retained placenta, and metritis was 3.7, 5.5, 3.4, and 4.3 times more likely, respectively, in cows that had SCHC than in cows with normocalcemia. Furthermore, the risk of incurring retained placenta or metritis increased in multiparous cows as serum Ca concentrations decreased compared with that in primiparous cows. Normocalcemic cows, independent of parity, were more likely to show their first estrus sooner after calving than SCHC cows, but no correlation was found between SCHC and other reproductive parameters. Different serum Ca concentration cutoffs were identified for several postpartum afflictions (≤1.93, ≤2.05, ≤2.05, and ≤2.10 mM for ketosis, retained placenta, metritis, and displaced abomasum, respectively). In conclusion, SCHC, defined as serum Ca ≤2.14 mM, is a frequent illness affecting the majority of the dairy cows with important repercussions on health. However, if SCHC were to be used to predict postpartum disease, different serum Ca cutoff points are likely to be needed because best predictive cutoff values varied among postpartum ketosis, displaced abomasum, retained placenta, and metritis.

show abstract

“…Our own experiments with pigs (Schlumbohm & Harmeyer, 1990) and sheep ) have indicated that hypocalcaemia might be of significance in vivo for the control of glucose metabolism. A reduction of glucose turnover in the presence of hyperketonaemia has also been reported in humans (Baron et al 1989) and dogs (Shaw & Wolfe, 1984).…”

mentioning

confidence: 94%

Effect of Hypocalcaemia on Glucose Metabolism in Hyperketonaemic Piglets

Schlumbohm

Harmeyer

1999

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

summaryIn nine 2-to 3-month-old hyperketonaemic piglets the kinetics of glucose and ª_â-hydroxybutyrate (ª-BHB) metabolism were studied during hypo-and normocalcaemia in paired experiments. Hyperketonaemia (1·3 and 2·5 mmol ª_BHB (l plasma)¢) was generated by a stepwise increase of ª¬-BHB infusion. Hypocalcaemia spontaneously developed in five piglets due to an inherited calcitriol deficiency and was induced in four control piglets by a continuous infusion of Naµ-EDTA. The method of single isotopic marker injections of glucose and ª_BHB was used to calculate replacement rates, rate constants and half-lives of glucose and ª_BHB in plasma. When ª¬-BHB was infused at the same rate into normo-and hypocalcaemic piglets, hypocalcaemia reduced the rate constant of glucose by 20-30% and the replacement rate of glucose by 34%. In the presence of hyperketonaemia, hypocalcaemia increased the rate of replacement of ª_BHB by 6-40%. The replacement rate represents the sum of endogenous production and the rate of ª¬_BHB infusion. This observation shows that the endogenous production of ª_BHB was higher during hypocalcaemia than during normocalcaemia.

show abstract

Hypocalcemia Reduces Rate of Disappearance of Glucose from Plasma

Cited by 8 publications

References 29 publications

Effect of Hypocalcaemia on Glucose Metabolism in Hyperketonaemic Piglets

Effect of Hypocalcaemia on Glucose Metabolism in Hyperketonaemic Piglets

Associations between subclinical hypocalcemia and postparturient diseases in dairy cows

Effect of Hypocalcaemia on Glucose Metabolism in Hyperketonaemic Piglets

Contact Info

Product

Resources

About