2020
DOI: 10.1111/jam.14656
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Hypochlorous acid-generating electrochemical scaffold eliminates Candida albicans biofilms

Abstract: Aims Wound infections involving Candida albicans can be challenging to treat because of the fungus’ ability to penetrate wound tissue and form biofilms. The goal of this study was to assess the activity of a hypochlorous acid (HOCl)‐generating electrochemical scaffold (e‐scaffold) against C. albicans biofilms in vitro and on porcine dermal explants (ex vivo). Methods and Results C. albicans biofilms were grown either on acrylic‐bottom six‐well plates (in vitro) or on skin tissue excised from porcine ears (ex v… Show more

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Cited by 20 publications
(16 citation statements)
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“…Porcine explant preparation was modified from previous explant models to accommodate an agar model (Zmuda et al, 2020 ). Ear tissue was harvested from fresh pigs (same day) from local butchers, immediately cooled to 4°C and transported to the laboratory for processing.…”
Section: Methodsmentioning
confidence: 99%
“…Porcine explant preparation was modified from previous explant models to accommodate an agar model (Zmuda et al, 2020 ). Ear tissue was harvested from fresh pigs (same day) from local butchers, immediately cooled to 4°C and transported to the laboratory for processing.…”
Section: Methodsmentioning
confidence: 99%
“…While demonstrating promising antibiofilm efficacy results, previous experiments were performed using carbon fabric electrodes immersed in a liquid solution. [46][47][48] Electrode potential was controlled using commercial benchtop potentiostats powered using an AC power source. [46][47][48] This system required further development to be suitable for use in animal models and ultimately human clinical settings.…”
Section: Outlook and Practical Implicationsmentioning
confidence: 99%
“…[46][47][48] Electrode potential was controlled using commercial benchtop potentiostats powered using an AC power source. [46][47][48] This system required further development to be suitable for use in animal models and ultimately human clinical settings. we demonstrated the development of a standalone H 2 O 2 producing e-bandage controlled by wearable potentiostat system that is designed to be applied to biofilms in a similar manner to the application of adhesive wound dressings; a hydrogel-based electrolyte was used to maintain ionic conductivity between e-bandage electrodes.…”
Section: Outlook and Practical Implicationsmentioning
confidence: 99%
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“…Wang et al, 2018;H. Wang et al, 2021), and to assess the toxicity to tissue due to HOCl (Zmuda et al, 2020).…”
mentioning
confidence: 99%