Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats

Miura, Daiki; Ito, Yukihiko; Mizukuchi, Aya; Kise, Mitsuo; Aoto, Hiromichi; Yagasaki, Kazumi

doi:10.1016/j.lfs.2006.01.001

Cited by 72 publications

(68 citation statements)

References 29 publications

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“…Miura et al (2006) have demonstrated that plasma T-chol is suppressed in rats fed a high cholesterol diet or in rats bearing a hepatoma following GBR intake and this suppression is related to dietary fiber. In the present study, the lack of effect of GBR intake on plasma T-chol levels could be explained by the fact that the mice were not fed additional cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…Although rice has a fundamental dietary role, there are few reports about its effect on general well-being and blood plasma factors (Morita et al, 2004;Ito et al, 2005;Seki et al, 2005;Miura et al, 2006;Kim et al, 2007a). Rice is generally polished before consumption to improve its taste even though unpolished brown rice (BR) and rice bran, a by-product of the rice-milling process, contain large amounts of essential dietary components including, vitamins, oryzanol (a mixture of components including sterols and ferulic acid), fiber, minerals, and gamma-aminobutyric acid (GABA) (Ardiansyah et al, 2006;Jariwalla, 2001;Champagne et al, 2004;Suzuki et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Shirai

Suzuki

et al. 2010

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The purpose of this study was to investigate the effect of extruded polished rice (PR), brown rice (BR), and germinated brown rice (GBR) on the behavior of ICR mice in a repeated open field test, as well as their concentrations of plasma lipids, glucose, and minerals. After 4 weeks in the open field test, the locomotion distance was significantly lower in mice fed GBR than those fed PR, but showed no difference in mice fed a diet with the same gamma-aminobutyric acid (GABA) content as GBR. The different rice diets had little influence on plasma lipids and glucose but the plasma calcium content was significantly higher in mice fed BR than those fed PR. These results suggest that the influence of GBR on mice behavior may be related to other components of GBR in addition to GABA and that BR and GBR may have no negative influence on mineral levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Shirai

Suzuki

et al. 2010

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“…Furthermore, in vitro studies have shown high adsorption of bile acid by rice bran (28,29). In a recent study, a PGBR diet suppressed hypercholesterolemia, and enhanced fecal bile acid excretion without affecting cholesterol synthesis in the host liver of hepatoma-bearing rats (30). With regard to nutritional guidelines for diabetes management, the accuracy of conventional guidance based on high carbohydrate consumption is being questioned.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pre-Germinated Brown Rice on Blood Glucose and Lipid Levels in Free-Living Patients with Impaired Fasting Glucose or Type 2 Diabetes

Hsu

Kise

Wang

et al. 2008

J Nutr Sci Vitaminol

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Summary White rice (WR) is made by polishing brown rice (BR) and has lost various nutrients; however, most people prefer it to BR, maybe because of the hardness of BR. Pregerminated brown rice (PGBR) improves the problem of BR. It is made by soaking BR kernels in water to germinate and becomes softer than BR. In this study we compared the effects of WR and PGBR on blood glucose and lipid concentrations in the impaired fasting glucose (IFG) or type 2 diabetes patients. Six men and 5 women with impaired fasting glucose (IFG) or type 2 diabetes were randomly allocated to 6 wk on WR or PGBR diet separated by a 2 wk washout interval in a crossover design. Each subject was instructed to consume 3 packs of cooked WR or PGBR (180 g/pack) daily in each intervention phase. Blood samples were collected 4 times (in study weeks 0, 6, 8 and 14) for biochemical examination. Blood concentrations of fasting blood glucose, fructosamine, serum total cholesterol and triacylglycerol levels were favorably improved on the PGBR diet ( p Ͻ 0.01), but not on the WR diet. The present results suggest that diets including PGBR may be useful to control blood glucose level.

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“…Serum biochemical tests showed that T-Cho was significantly lower in the PGBR group, and the weights of adipose tissues around the testicles and the kidney were about 8% lower in the PGBR group, although when compared with the control group this difference was not significant. Miura et al (2006) found that intake of PGBR increased the activity of cholesterol 7α hydroxylase and the levels of cholesterol metabolites. Based on this, it is possible that the effects of various components in PGBR may have caused a decrease in serum cholesterol.…”

Section: Discussionmentioning

confidence: 95%

Antihypertensive Effect of Pre-germinated Brown Rice in Spontaneously Hypertensive Rats

Ebizuka

Ihara

Arita

2009

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We examined the effects of pre-germinated brown rice on hypertension and biochemical analysis of blood in spontaneously hypertensive rats (SHRs) fed a diet including 40% pre-germinated brown rice. A significant antihypertensive effect (p < 0.01) was found from day 10 of food intake, compared to controls. At completion of the test period (8 weeks), SBP in the control and test groups were 207.4 ± 5.3 and 151.6 ± 4.5 mmHg, respectively, showing a significant (p < 0.001) and strong antihypertensive effect of pregerminated brown rice. The cholesterol levels in the control and test groups were 45.3 ± 5.4 and 37.5 ± 3.9 mg/dL, respectively, which also showed a significant difference (p < 0.01). Taken together, pre-germinated brown rice has an antihypertensive effect and decreases serum cholesterol in SHRs. These effects may be due to complex actions of various components abundantly found in the rice, including γ-aminobutyric acid, dietary fiber, phytic acid and ferulic acid.

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Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats

Cited by 72 publications

References 29 publications

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Effects of Pre-Germinated Brown Rice on Blood Glucose and Lipid Levels in Free-Living Patients with Impaired Fasting Glucose or Type 2 Diabetes

Antihypertensive Effect of Pre-germinated Brown Rice in Spontaneously Hypertensive Rats

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