Hypocholesterolemic and hypoglycemic effects of enzymatically modified carbohydrates from rice in high‐fat‐fed C57BL/6J mice

Bhuiyan, Muhammad Javidul Haque; Do, Ha Viet; Mun, Saehun; Jun, Hee-Jin; Lee, Ji Hae; Kim, Yong Ro; Lee, Sung Joon

doi:10.1002/mnfr.201100121

Cited by 17 publications

(12 citation statements)

References 52 publications

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“…Total RNA was extracted from HepG2 cells as described previously [] after treatment with different concentrations of AX or fenofibrate (10 μM), GW0742 (1 μM), and troglitazone (10 μM) for 24 h. DMSO (1%) was used as a vehicle. Real‐time qPCR was performed with Bio‐Rad iQ SYBR® Green Supermix reagent and the Bio‐Rad iQ5 Cycler System (Bio‐Rad, Hercules, CA).…”

Section: Methodsmentioning

confidence: 99%

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The natural carotenoid astaxanthin, a PPAR‐α agonist and PPAR‐γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid‐loaded hepatocytes

Jia¹,

Kim²,

Jun³

et al. 2012

Molecular Nutrition Food Res

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109

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Section: Methodsmentioning

confidence: 99%

“…Cytosolic lipid droplet formation was induced in HepG2 cells as described previously []. Lipid‐ and nonlipid‐loaded HepG2 cells were treated with 100 μM AX, 10 μM fenofibrate, or 10 μM lovastatin, with 1% DMSO as the vehicle.…”

Section: Methodsmentioning

confidence: 99%

The natural carotenoid astaxanthin, a PPAR‐α agonist and PPAR‐γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid‐loaded hepatocytes

Jia¹,

Kim²,

Jun³

et al. 2012

Molecular Nutrition Food Res

Self Cite

109

View full text Add to dashboard Cite

show abstract

“…Maintaining cholesterol levels in the normal range can help prevent the initiation and progression of CVD. Although several effective drugs have been developed to treat hypercholesterolemia, the risk factors for CVD can be modulated by diet (2). …”

Section: Introductionmentioning

confidence: 99%

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

Um¹,

Ahn²,

Jung³

et al. 2013

JFN

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The aim of this study was to investigate the effects of isolated protein from white rice on lipid metabolism in a hypercholesterolemic animal model. Male Sprague-Dawley rats were divided into three groups and fed either a normal diet or a high-cholesterol diet (HCD) containing either casein or isolated rice protein for 4 weeks. Compared with rats fed a HCD with casein, the total cholesterol (TC) level in the plasma was significantly reduced in the rats fed rice protein. However, no significant differences were observed in the triglycerides, high-density lipoprotein (HDL), and glucose levels among the experimental groups. Hepatic total lipids and TC levels were significantly decreased by supplementation with rice protein. In addition, rice protein significantly increased the levels of TC and bile acids in the feces. These results suggest that rice protein may improve HCD-induced hypercholesterolemia by enhancing fecal excretion of cholesterol.

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“…This allows to check the carbohydrate metabolism behaviour (Bhuiyan et al, 2011), as through this test it is possible to evaluate the ability of probable anti-diabetic drugs to reduce the postprandial blood glucose and to define the dose responsible for such activity.…”

Section: Resultsmentioning

confidence: 99%

Effect of hydroethanolic extract from Calophyllum brasiliense Cambess on streptozotocin induced diabetic rats

Carvalho¹,

Lacerda²,

Ferreira³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Calophyllum brasiliense (Cb) belongs to the Clusiaceae family and it is generally used for diabetes treatment. The aim of this study was to evaluate the anti-diabetic effect of Cb's hydroethanolic extract (CBE) on diabetic induced rats by streptozotocin and evaluate the content of polyphenols and tannins of the extract. The polyphenols and tannins evaluation in the extract were determinated by a spectrophotometer in 760 nm and isocratic HPLC system and reverse phase column (C18). The induction of diabetes was performed by intraperitoneal injection of streptozotocin (55 mg/kg) and was confirmed by a histopathological analysis. The total content of polyphenols and tannins (gallic acid) in CBE was 0.025 ± 0.0028 mg/mL (4.77%) and 8.262 ± 0.417 µg/mL, respectively. According to the oral glucose tolerance test that was performed both in normal and diabetic mice, the treatment with 500 mg/kg of CBE appeared to significantly reduce the blood glucose levels compared to the untreated group (P < 0.001). The treatment of diabetic mice with 500 mg/kg of CBE for 30 days significantly improved diabetes clinical symptoms (polydipsia, polyuria, polyphagia and weight loss) (P < 0.001). After the urinary glucose analysis, it was found that the treatment with 500 mg/kg of CBE significantly decreased the urinary glucose levels at an average of 177.55 ± 17.8 mg/dL (32.40%) (P < 0.001). In relation to the blood glucosemeasurements, it was shown that the groups treated with 500 mg/kg CBE and 3 mg/kg of Glibenclamide had significantly lower levels of blood glucose when compared to nontreated group (P < 0.001) 24.09% (143.36 ± 19.6 mg/dL) and 36.04% (200.08 ± 14.9 mg/dL), respectively). The histopathological analysis revealed an increase in the number of endocrine cells in the islets of Langerhans in the groups treated with CBE500 and insulin. Therefore, it was concluded that the treatment with 500 mg/kg of CBE exhibited anti-diabetic activity.

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Hypocholesterolemic and hypoglycemic effects of enzymatically modified carbohydrates from rice in high‐fat‐fed C57BL/6J mice

Abstract: Our data suggest that ERS feeding may have hypoglycemic and hypocholesterolemic effects via a mechanism similar to that of dietary fiber.

Cited by 17 publications

References 52 publications

The natural carotenoid astaxanthin, a PPAR‐α agonist and PPAR‐γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid‐loaded hepatocytes

The natural carotenoid astaxanthin, a PPAR‐α agonist and PPAR‐γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid‐loaded hepatocytes

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

Effect of hydroethanolic extract from Calophyllum brasiliense Cambess on streptozotocin induced diabetic rats

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