Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet

Gunathilake, K.D.P.P.; Wang, Y.; Rupasinghe, H.P. Vasantha

doi:10.1016/j.jff.2013.05.007

Cited by 23 publications

(12 citation statements)

References 41 publications

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“…Theaflavins, the major polyphenols in black tea, have been demonstrated to have lipid-lowering effects (Jin et al, 2013). Furthermore, Gunathilake, Wang, and Vasantha Rupasinghea (2013) recently demonstrated that a polyphenol-rich fruit-based functional beverage was able to significantly lower liver cholesterol and total and non-HDLcholesterol levels in spontaneously hypertensive rats fed a cholesterol-rich diet.…”

Section: Nutraceutical Effects On Dyslipidaemia: Action Mechanismsmentioning

confidence: 99%

Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

Scicchitano

Cameli

Maiello³

et al. 2014

Journal of Functional Foods

326

236

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Section: Nutraceutical Effects On Dyslipidaemia: Action Mechanismsmentioning

confidence: 99%

Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

Scicchitano

Cameli

Maiello³

et al. 2014

Journal of Functional Foods

326

236

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“…One group of such natural compounds is the polyphenols, which are highly abundant in plant products and are known inhibitors of the RAS components, especially ACE (Actis- Goretta et al, 2006;Takahashi et al, 2008;Xie & Zhang, 2012;Shaw et al, 2017). For example, oral administration of a polyphenolic-rich fruit beverage to spontaneously hypertensive rats (SHR) resulted in decreased blood pressure (Gunathilake et al, 2013). Chokeberry juice and its polyphenols at a dose of 50 mg kg À1 body weight/day were also reported to produce substantial reductions in SHR blood pressure (Hellstrom et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive properties of aqueous extracts of vegetable leaf‐fortified bread after oral administration to spontaneously hypertensive rats

Alashi

Taiwo

Oyedele

et al. 2018

Int J of Food Sci Tech

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Summary This study investigated the potential cardiovascular health benefits of leavened bread produced from wheat flour that contained 1%, 2% and 3% additions of leafy vegetable powders obtained from Amaranthus viridis (AO), Solanum macrocarpon (SM) or Telfairia occidentalis (TO). Dried breads were extracted with water at 60 °C followed by analysis for total polyphenolic content (TPC), as well as in vitro inhibitions of angiotensin‐converting enzyme and renin activities. HPLC analysis of the bread extracts indicated the presence of mainly rutin, gallic acid, myricetin and caffeic acid. TPC of the vegetable‐fortified breads was significantly (P < 0.05) higher (5.8–7.6 mg gallic acid equivalent, GAE/g) than that of control bread (5.5 mg GAE/g). Oral administration of 100 mg dried extract/kg body weight to spontaneously hypertensive rats led to reductions (up to 42 mmHg) in systolic, diastolic and mean arterial blood pressure in comparison with 20 mmHg for the control bread.

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“…Some have pointed significant reductions in LDL levels in both animals (Albert et al, 1999) and humans (Gunathilake et al, 2013;Rosenkranz et al, 2002), while others has reported no effect (Peres et al, 2012). This controversy could be explained by differing in experimental design, especially regarding dose of polyphenols used and time of exposure.…”

Section: Discussionmentioning

confidence: 99%

Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans

Peres

Gollucke

Soares

et al. 2015

International Journal of Food Sciences and Nutrition

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The aim of this study was to investigate the phenolic composition of a natural food colourant (G8000™) as well as its effects on plasma markers after 28-day consumption by healthy individuals at a dietary dose (70 g). Parameters of total cholesterol and its fractions, triglycerides and plasma enzymes biomarkers of muscle injury were measured. Major compounds identified in G8000™ by ESI-MS showed the presence of anthocyanins, organic acids, phenolic acids as well as monosaccharides. HDL levels significantly increased from 43 ± 10.2 mg/dL to 95 ± 16.9 mg/dL. LDL levels significantly decreased from 110 ± 40.9 mg/dL to 69 ± 39 mg/dL (p < 0.001). No significant statistical differences (p > 0.05) were observed for total cholesterol, triglycerides and VLDL. After the intake, plasma enzyme CK-MB decreased from 20 ± 12.1 U/L to 10 ± 1.9 U/L while LDH levels increased from 275 ± 124.4 U/L to 317 ± 114.7 U/L (p < 0.005). No significant differences were observed for CK levels. Taken together, dietary intake of natural colourant G8000™ was able to exert beneficial effects on atherosclerosis biomarkers.

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Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet

Cited by 23 publications

References 41 publications

Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

Antihypertensive properties of aqueous extracts of vegetable leaf‐fortified bread after oral administration to spontaneously hypertensive rats

Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans

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