Hypocholesterolemic effect of aqueous extract of the rhizomes of Sansevieria liberica on salt-loaded rats

Abstract

In this study, the ability of an aqueous extract of the rhizomes of Sansevieria liberica to moderate plasma lipid profile and atherogenic indices was investigated in normal and sub-chronic salt-loaded rats. The normal and treatment control groups received a diet consisting 100% of the commercial feed, while the test control, reference and test treatment groups received an 8% salt-loaded diet. The extract was orally administered daily at 100 and 200 mg/kg body weight; while the moduretics was administered at 1 mg/kg body weight. The test control, reference and control groups received appropriate volumes of water by the same route. Compared to test control, the extract dose dependently significantly lowered (P<0.05) the plasma triglyceride, total-, very low density lipoprotein (VLDL)-, low density lipoprotein (LDL)- and non-high density lipoprotein (non-HDL) cholesterol levels, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma, while significantly (P<0.05) increasing the plasma high density lipoprotein (HDL) cholesterol concentration of the test animals. The present result highlighted the cardio-protective potential of the plant, and suggests its use in the management of dyslipidemia whether primary or secondary to obesity, diabetes mellitus and hypertension, and by extension, the reduction of the risk of cardiovascular diseases.

Antioxidative Potentials of Cooked Bambara Groundnut Based Diet (Vigna Subterranean) on Lipid Peroxidation Status in Pretreated Alloxan Induced Diabetic Rats

“…The increase observed in lipid peroxidation in the heart and plasma of Diabetic rats is consistent with the reports of. [18,19] Oxidative stress in diabetes coexists with a reduction in antioxidant capacity, which can increase the deleterious effect of free radicals. Alloxan and the product of its reduction, dialuric acid, establishes a redox cycle with the formation of superoxide radicals.…”

A review: Potensi Dracaena liberica (Gérôme & Labroy) Christenh sebagai etnomedicine dan treaupetic

“…D. liberica, known as "Ida orisa" in West Nigeria (Agavaceae), is traditionally used for the treatment of asthma, diabetes, stomach pain, hypertension, menorrhagia, and sexual dysfunction [22], [23]. In traditional Nigerian medicine, the leaves and roots of the plant are used to treat stomachaches, asthma, diarrhea, skin diseases (eczema), gonorrhea, hemorrhoids, hypertension, sexual weakness, snakebites, and wounds [3], [5].…”

“…The plant's extracts have also demonstrated antidiarrheal [5] , central nervous system depressant, anticonvulsant [5], [27], analgesic, and anti-inflammatory activities [9]. Furthermore, D. liberica has been reported to possess antihypertensive, anticancer, diuretic, antioxidant, hepatoprotective, hypoglycemic, and antihyperglycemic activities [11], [12], [23]; [34], [35]. Several compounds isolated from its stem bark and leaves include mpavetannin, aplysamine-2, abscisic acid, α-conidendinin, and quercetin-3-O-α-Larabinofuranoside [10].…”

“…Several compounds isolated from its stem bark and leaves include mpavetannin, aplysamine-2, abscisic acid, α-conidendinin, and quercetin-3-O-α-Larabinofuranoside [10]. Terpenoids such as β-stigmasterol, β-sitosterol, and campesterol have also been isolated from the plant [23]. In a recent study, Ayoola and colleagues reported significant and consistent antihyperglycemic and antioxidant activities from extracts, partitioned fractions, and columns of its rhizomes [36].…”

Recent developments in animal sciences

“…Particularly, the advent of transgenic and knockout technologies together with the generation of humanized animals (Hammad et al, 2013[ 10 ]) opens exciting possibilities. A second field of interest is traditional and applied animal sciences including farm animals, animal nutrition and related fields of veterinary medicine (Mallaiah et al, 2014[ 16 ]; Soriano-Úbeda et al, 2013[ 21 ]; Mishra et al, 2013[ 17 ]; Zarrindast et al, 2013[ 22 ]; Ikewuchi et al, 2013[ 12 ]).…”