Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

Kang, Hyung Seok; Pichiah, Pichiah Balasubramanian Tirupathi; Abinaya, Ravichandran Vijaya; Sohn, Hee Sook; Cha, Youn‐Soo

doi:10.1007/s10068-016-0141-4

Cited by 17 publications

(8 citation statements)

References 34 publications

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“…This result was in agreement with Kang et al . (); who observed the liver weight gain in mice fed with HCD. Furthermore, the increase of epididymal and perirenal adipose tissue weight was also observed in HC group, which was connected with the increasing body mass as shown in Fig.…”

Section: Resultsmentioning

confidence: 98%

Anthocyanin extracts of lingonberry (Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD‐induced hypercholesterolaemic male mice

Zhang

Zhou

Huangfu

et al. 2018

Int J of Food Sci Tech

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This study is aimed to evaluate the hypocholesterolaemic effect of anthocyanin extracts of lingonberry (LAE) in vitro and vivo studies. In vitro, LAE can effectively inhibit the micellisation of cholesterol with significant dose-effect relationship. In animal experiments, after 10-weeks of LAE administration, lower values of body mass, daily food intake, liver weight, visceral adipose content, TC level, LDL-C level, fasting blood glucose level and higher HDL-C level in serum, cholesterol content and total bile acid content in faeces are observed in HCD-induced hypercholesterolaemic mice compared with model group. These observations suggest that LAE could promote the metabolism of serum cholesterol in HCD-induced hypercholesterolaemic mice primarily via faecal excretion of cholesterol. Furthermore, LAE may reduce the inflammatory cell infiltration and attenuate steatosis and hepatocellular fat deposit in the liver. Our results indicate that LAE is a potential dietary supplement in cholesterol-lowering or for hypercholesterolaemic treatment. These findings may provide important basis for further optimisation of dietary anthocyanins utilisation.

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Section: Resultsmentioning

confidence: 98%

Anthocyanin extracts of lingonberry (Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD‐induced hypercholesterolaemic male mice

Zhang

Zhou

Huangfu

et al. 2018

Int J of Food Sci Tech

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“…Serum lipid analysis was performed as described previously (Kang, Pichiah, Abinaya, Sohn, & Cha, 2016). Serum concentrations of TC, TG, HDL‐C, and LDL‐C were determined using commercial assay kits (Nanjing Jiancheng Bioengineering Institute).…”

Section: Experiments Methodsmentioning

confidence: 99%

Nostoc sphaeroids Kütz ameliorates hyperlipidemia and maintains the intestinal barrier and gut microbiota composition of high‐fat diet mice

Wei

Liu

et al. 2020

Food Science & Nutrition

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Hyperlipidemia is associated with chronic inflammation and intestinal dysbiosis. The purpose of this study was to investigate the protective effect of Nostoc sphaeroids Kütz (NO) on diet‐induced hyperlipidemia in mice. Experimental animals received a high‐fat diet (HFD) for 4 weeks, then an HFD supplemented with 2.5% or 7.5% NO for 6 weeks. HFD‐fed mice exhibited a significant increase in serum total cholesterol, triglycerides, and low‐density lipid cholesterol, and a decrease in high‐density lipid cholesterol. NO supplementation was associated with significantly lower dyslipidemia, decreased intestinal inflammation, and inhibition of toll‐like receptor 4 gene repression in HFD‐fed mice. Results suggest that NO treatment protected the integrity of the intestinal barrier. NO treatment was also associated with significant changes in the intestinal microbiota induced by HFD and an increase in the Firmicutes‐to‐Bacteroidetes ratio. Furthermore, NO treatment was also inversely correlated with mice obesity and hyperlipidemia NO and was associated with no significant in fecal short‐chain fatty acids. In conclusion, NO significantly ameliorated hyperlipidemia induced by a HFD in mice, potentially via a decrease intestinal inflammation, increase in intestinal barrier integrity, and amelioration in the gut microbiota.

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“…Altogether, these studies demonstrated that Qu may be a promising drug for the treatment and prevention of atherosclerosis in ASCVD. Wistar rats Elevate activity of hepatic CYP7A1, LXRα, and ABCG1 to promote cholesterol-to-bile acid conversion and cholesterol efflux [114] C57BL/6J mice Upregulate LDLR and CYP7A1 gene expression to facilitate the removal of cholesterol via fecal excretion [115] Wistar rats…”

Section: Elimination Of Etiology Reduction Of Complications and Effmentioning

confidence: 99%

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

Deng

Fang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest morbidity and mortality globally. It causes a huge burden on families and caregivers and high costs for medicine and surgical interventions. Given expensive surgeries and failures of most conventional treatments, medical community tries to find a more cost-effective cure. Thus, attentions have been primarily focused on food or herbs. Quercetin (Qu) extracted from food, a flavonoid component, develops potentials of alternative or complementary medicine in atherosclerosis. Due to the wide range of health benefits, researchers have considered to apply Qu as a natural compound in therapy. This review is aimed to identify the antiatherosclerosis functions of Qu in treating ASCVD such as anti-inflammatory, antioxidant properties, effects on endothelium-dependent vasodilation, and blood lipid-lowering.

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Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

Cited by 17 publications

References 34 publications

Anthocyanin extracts of lingonberry (Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD‐induced hypercholesterolaemic male mice

Anthocyanin extracts of lingonberry (Vaccinium vitis‐idaea L.) attenuate serum lipids and cholesterol metabolism in HCD‐induced hypercholesterolaemic male mice

Nostoc sphaeroids Kütz ameliorates hyperlipidemia and maintains the intestinal barrier and gut microbiota composition of high‐fat diet mice

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

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