Hypocrellin and hypericin-induced phototoxicity of HL-60 cells: apoptosis or necrosis?

Miroššay, A.; Mojžiš, Ján; Tóthová, Jana; Hajikova, M; Lackova, Alexandra; Mirossay, Ladislav

doi:10.1016/s0944-7113(00)80032-x

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…Hypocrellins, as dominant compounds, were extracted from S. bambusicola (Wan and Chen, 1981), and have attracted a great deal of attention because of their lightinduced antifungal, antiviral and antitumor activity, especially against the human immunodeficiency virus (HIV) (Kocisova et al, 1999;Wang et al, 1999;Mirossay et al, 2000;Xu et al, 2001;Yang et al, 2001;Ali and Olivo, 2002;Deininger et al, 2002;Zhou et al, 2003;Chin et al, 2004). However, its efficient antimicrobial activity was only against clinical pathogens and there have been few reports of the antimicrobial activity against plant pathogens (Ma et al, 2004;Su et al, 2009).…”

Section: S T a P H Y L O C O C C U S Aureus B A Ci L L U S Subtilis Lmentioning

confidence: 99%

Isolation and evaluation of endophytic fungi with antimicrobial ability from Phyllostachys edulis

Shen

Zheng

Gao

et al. 2012

Bangladesh J Pharmacol

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Section: S T a P H Y L O C O C C U S Aureus B A Ci L L U S Subtilis Lmentioning

confidence: 99%

Isolation and evaluation of endophytic fungi with antimicrobial ability from Phyllostachys edulis

Shen

Zheng

Gao

et al. 2012

Bangladesh J Pharmacol

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“…Apoptotic (Q4) and necrotic (Q2) cell death mechanisms has been demonstrated in the cultured cells which are in agreement with our findings. 56 The Annexin V + /PI + cells (Q2) presented in the control group may be attributed to the maturity related apoptosis. Figure 10 shows the fluorescent microscopy images of JC-1 stained DLA cells after PDT using CHA 2 HB formulations compared to untreated control.…”

Section: Cha 2 Hb Formulations Induce Apoptotic As Well As Necrotic Cmentioning

confidence: 97%

Polyethylene Glycol-Modified Gelatin/Polylactic Acid Nanoparticles for Enhanced Photodynamic Efficacy of a Hypocrellin Derivative In Vitro

Babu¹,

Periasamy²,

Gunasekaran³

et al. 2013

j biomed nanotechnol

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The present study focused on the development of a novel biodegradable nanoparticle system based on polyethyleneglycol-modified gelatin (PEG-GEL) and polylactic acid (PLA) biopolymers for improving the photodynamic efficacy of cyclohexane-1,2-diamino hypocrellin B (CHA2HB), a potent photodynamic therapeutic (PDT) agent. The CHA2HB-loaded PEG-GEL/PLA nanoparticles showed near-spherical morphology with an average size of 190 nm at a PLA to PEG-GEL ratio of 1:3. The drug loading was sufficient enough to produce potentially toxic reactive oxygen species (ROS) needed for photodynamic therapy (PDT). Slow and controlled drug release was observed in normal conditions, whereas enzyme assistance resulted in a relatively fast release due to partial disintegration of CHA2HB-loaded PEG-GEL/PLA nanoparticles. In vitro experiments indicated that CHA2HB-loaded PEG-GEL-PLA nanoparticles are efficiently taken up by cancer cells such as human breast adenocarcinoma (MCF-7), human gastric sarcoma (AGS) and mice specific Dalton's lymphoma (DLA) in a time dependent manner. Further, CHA2HB-loaded PEG-GEL/PLA nanoparticles evoked superior phototoxicity compared to free-CHA2HB towards all the three cell lines investigated. Interestingly, PDT effectiveness was different for the different cell type studied. CHA2HB-loaded PEG-GEL/PLA nanoparticles induced both apoptotic and necrotic cell death as a result of photoirradiation. Thus, our data suggest that PEG-GEL/PLA nanoparticles are highly effective in delivery and phototoxic enhancement of CHA2HB against model cancer cells in vitro.

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“…Hypericin (Fig. 1) is a naturally occumng perylene quinone that has gained great interest recently because of its biological activity (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), in particular, its light-induced biological activity (21)(22)(23)(24)(25). The importance of light for its function has motivated our study of the photophysics of hypericin and its analogs (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Ntro Du Ctlo Nmentioning

confidence: 99%

The Separation of Hypericin's Enantiomers and Their Photophysics in Chiral Environments^¶

Sanders¹,

Halder²,

Xiao³

et al. 2005

Photochem & Photobiology

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We report the first separation of the enantiomers of hypericin. Their steady‐state optical spectra and ultrafast primary photoprocesses are investigated in chiral environments. Within experimental error, there is no difference between the two enantiomers in any of the systems considered. This is consistent with the emerging picture that the rich and extended absorption spectrum of hypericin is not a result of ground‐state heterogeneity. It is also consistent with the observation that the spectra and photophysics of hypericin are generally insensitive to environments in which it does not aggregate.

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Hypocrellin and hypericin-induced phototoxicity of HL-60 cells: apoptosis or necrosis?

Cited by 16 publications

References 24 publications

Isolation and evaluation of endophytic fungi with antimicrobial ability from <i>Phyllostachys edulis </i>

Isolation and evaluation of endophytic fungi with antimicrobial ability from <i>Phyllostachys edulis </i>

Polyethylene Glycol-Modified Gelatin/Polylactic Acid Nanoparticles for Enhanced Photodynamic Efficacy of a Hypocrellin Derivative <I>In Vitro</I>

The Separation of Hypericin's Enantiomers and Their Photophysics in Chiral Environments^¶

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Hypocrellin and hypericin-induced phototoxicity of HL-60 cells: apoptosis or necrosis?

Cited by 16 publications

References 24 publications

Isolation and evaluation of endophytic fungi with antimicrobial ability from <i>Phyllostachys edulis </i>

Isolation and evaluation of endophytic fungi with antimicrobial ability from <i>Phyllostachys edulis </i>

Polyethylene Glycol-Modified Gelatin/Polylactic Acid Nanoparticles for Enhanced Photodynamic Efficacy of a Hypocrellin Derivative <I>In Vitro</I>

The Separation of Hypericin's Enantiomers and Their Photophysics in Chiral Environments¶

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The Separation of Hypericin's Enantiomers and Their Photophysics in Chiral Environments^¶