Hypodermic-Needle-Like Hollow Polymer Microneedle Array: Fabrication and Characterization

Wang, Po-Chun; Paik, Seung-Joon; Kim, Seong-Hyok; Allen, Mark G.

doi:10.1109/jmems.2014.2307320

Cited by 32 publications

(26 citation statements)

References 24 publications

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“…1b ). This tip geometry has been shown to minimize the force required for skin penetration, making it similar to that of a conventional 26-gauge hypodermic needle 25 . Microneedles are configured in a 4 × 4, two-dimensional array to increase the rate of sample extraction, with a needle-to-needle spacing of 2 mm (Fig.…”

Section: Resultsmentioning

confidence: 99%

Microneedle-based skin patch for blood-free rapid diagnostic testing

Jiang

Lillehoj

2020

Microsyst Nanoeng

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Rapid diagnostic tests are one of the most commonly used tests to detect and screen for infectious diseases in the developing world. While these tests are simple, inexpensive, and readily available, they rely on finger-prick blood sampling, which requires trained medical personnel, poses risks of infection, and can complicate cooperation in young children, asymptomatic individuals, and communities with blood taboos. Here, we report a novel microneedle-based skin patch for the rapid detection of protein biomarkers in dermal interstitial fluid. Sample collection is facilitated by a hydrophilic hollow microneedle array that autonomously extracts and transports interstitial fluid to an antibody-based lateral flow test strip via surface tension for colorimetric antigen detection. We employ a simple gold enhancement treatment to enhance the detection sensitivity of this colloidal gold-based lateral flow assay and elucidate the underlying mechanism of this enhancement mechanism through experimental investigation. For proof-of-concept, this device was used to detect Plasmodium falciparum histidine-rich protein 2, a biomarker for malaria infection, which could be detected at concentrations as low as 8 ng/mL. Each test can be completed in <20 min and requires no equipment. To the best of our knowledge, this work is the first demonstration of a microneedle-based lateral flow assay for rapid protein detection in dermal interstitial fluid. In addition to its simplicity, minimally invasive nature, and low cost, this diagnostic device can be readily adapted to detect other protein biomarkers in interstitial fluid, making it a promising tool for point-of-care testing.

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Section: Resultsmentioning

confidence: 99%

Microneedle-based skin patch for blood-free rapid diagnostic testing

Jiang

Lillehoj

2020

Microsyst Nanoeng

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“…A discontinuity in the detected force in the graph indicated the fractured threshold force for the microneedle, which was also confirmed by visual observation during the test. By testing 100 microneedles from 10 MFS devices, the average buckling force was as much as 1.92N ± 0.16N, It was much larger than the minimal required penetration force (less than 0.5 N) for the microneedles with similar geometry and dimension [38], which proved that the fabricated microneedles were strong enough to penetrate skin surface.…”

Section: B Stiffness Testing and Penetration Testing For Mfsmentioning

confidence: 97%

Development of a Flexible and Disposable Microneedle-Fluidic-System With Finger-Driven Drug Loading and Delivery Functions for Inflammation Treatment

Xiang

Wang

Pastorin

et al. 2015

J. Microelectromech. Syst.

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Patch-based transdermal drug delivery technology offers a convenient way to administer drugs without the drawbacks of standard hypodermic injections related to issues, such as patient acceptability and injection safety. In this paper, we developed a flexible and disposable microneedle-fluidicsystem (MFS), which can achieve finger driven on-chip drug loading and delivery functions by integrating polydimethylsiloxane-based microfluidic dispensing networks, check valves, micropump, and SU-8 microneedles in a patch device. The control of particular loading or delivery volume for drugs is provided in terms of finger pressing to a micropump with a given dimension. The in vitro mechanical testing, penetration testing, and delivery testing prove the device functionalities. The local inflammation phenomenon of rats has been ameliorated with the aid of successful diclofenac deliver by our MFS patch.[ 2015-0046]Index Terms-Finger driven, local inflammation treatment, microneedles, personal healthcare device.

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“…Hollow microneedles have been developed to allow the transfer of a drug from a reservoir within the patch to the microcirculation and can enable volumes of up to 200 μL to be transported. In many respects, the system mimics the operation of a conventional hypodermic syringe [ 42 , 48 , 49 , 50 , 51 ]. It must be noted that hollow needle fabrication is significantly more complex and those possessing a high aspect ratio lack the internal support structure common to solid needles, leading to potential failure if improperly inserted.…”

Section: The Quest For Needle-free Deliverymentioning

confidence: 99%

Mini-Review: Assessing the Potential Impact of Microneedle Technologies on Home Healthcare Applications

2018

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The increasing devolution of healthcare towards community care has meant that the management of many conditions is conducted within the home either by community nurses or by the patients themselves. The administration of medicines within home healthcare scenarios can however be problematic—especially when considering the delivery of medicines through injection. The possibility of needlestick injury (NSI) has become an ever-present hazard within healthcare settings, with a significant proportion of percutaneous injuries occurring during the handling and disposal of the needle. The emergence of transdermal microneedle systems, however, offers a potentially revolutionary advance and could dramatically improve safety—particularly within home healthcare where there are mounting concerns over the use and disposal of sharps. A mini-review of the advantages proffered by microneedle drug delivery technologies is presented and the potential impact on delivery of medicines within the home is critically appraised.

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Hypodermic-Needle-Like Hollow Polymer Microneedle Array: Fabrication and Characterization

Cited by 32 publications

References 24 publications

Microneedle-based skin patch for blood-free rapid diagnostic testing

Microneedle-based skin patch for blood-free rapid diagnostic testing

Development of a Flexible and Disposable Microneedle-Fluidic-System With Finger-Driven Drug Loading and Delivery Functions for Inflammation Treatment

Mini-Review: Assessing the Potential Impact of Microneedle Technologies on Home Healthcare Applications

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