Hypoehoic lesions on Transrectal Ultrasound and its correlation to Gleason grade in the diagnosis of Clinically Significant Prostate Cancer: A Prospective Study

Sharma, Manas; Nerli, Rajendra B; Nutalapati, Sree Harsha; Ghagane, Shridhar C

doi:10.1055/s-0041-1731906

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Hypoechoic lesions on TRUS can often represent prostate cancer and evidence suggests that hypoechoic lesions seen during systematic biopsy are predictors for clinically significant prostate cancer (98)(99)(100)(101). However, whether routinely targeting these lesions increases diagnostic yield is less conclusive with conflicting results.…”

Section: Ultrasound Targetedmentioning

confidence: 99%

Prostate Cancer Diagnosis: Biopsy Approaches

et al. 2022

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Prostate cancer is a common and increasing malignancy in men. Tissue is generally obtained using prostate biopsy for diagnosis and risk stratification. There are many prostate biopsy techniques. Historically, the transrectal approach has been the most adopted. In many centers, however, there has a been a shift towards transperineal Note to the Reader: This chapter is part of the book Urologic Cancers (ISBN: 978-0-6453320-5-6), scheduled for publication in July 2022. The book is being published by Exon Publications,

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Section: Ultrasound Targetedmentioning

confidence: 99%

Prostate Cancer Diagnosis: Biopsy Approaches

et al. 2022

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Metal-organic framework-based electrochemical aptasensors for detecting cancer biomarkers

WU,

SHI,

CHEN

et al. 2022

Journal of Holistic Integrative Pharmacy

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Role of Transrectal Ultrasound and Elastography in the Diagnosis of Prostate Lesions

Gupta

Phatak

2022

Journal of Datta Meghe Institute of Medical Sciences University

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Background: The incidence of malignancy of prostate gland has displayed a rapid rise over recent times. Transrectal ultrasound (TRUS) has brought revolution to radiologist's human prostate imaging methods. Information regarding elasticity of suspicious or abnormal lesions provided by strain elastography can enhance the detection rate of prostate malignancies as well as serve as a reliable visual guide for biopsy from these sites. In this prospective study, we aim to appraise the use of TRUS for diagnosing prostatic lesions, both benign and malignant, and compare it to the utility of strain elastography to precisely locate and guide biopsies of lesions while referring to the pathological diagnosis as the reference standard, wherever possible/needed. Materials and Methods: This was a prospective, cross-sectional study involving 82 male patients who were clinically suspected to have prostate malignancy. The patients were referred to the Department of Radiodiagnosis, AVBRH, where they underwent transrectal ultrasonography and elastography with Hitachi Aloka ultrasound (USG) Machine Arietta S70 with biplane high-frequency transrectal probe (6–10 MHz) with elastography. Results: TRUS had high sensitivity (92.45%) and specificity (78.38%) for cancer detection. Strain elastography had a sensitivity of 96.23%, specificity of 81.08%, positive predictive value (PPV) of 70.83%, and negative predictive value (NPV) of 97.83%. Based on our findings, real-time elastography had more sensitivity and higher NPV than TRUS for the identification of prostatic cancer. Hence, it can be concluded that elastography is an effective assessment tool for ruling out the possibility of malignant tumors, helping to reduce redundant biopsies. Conclusions: Transrectal ultrasonography (TRUS) is an effective tool for the assessment of prostatic lesions. TRUS has high specificity, sensitivity, NPV, and PPV when assessing lesions for prostatic cancer. Elastography has high sensitivity, high specificity, high PPV, and reliable NPV when detecting for prostatic cancer. The combination of TRUS and elastography can help more efficiently assess lesions and guide biopsies to increase the identification rate of prostatic cancer.

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Hypoehoic lesions on Transrectal Ultrasound and its correlation to Gleason grade in the diagnosis of Clinically Significant Prostate Cancer: A Prospective Study

Cited by 3 publications

References 27 publications

Prostate Cancer Diagnosis: Biopsy Approaches

Prostate Cancer Diagnosis: Biopsy Approaches

Metal-organic framework-based electrochemical aptasensors for detecting cancer biomarkers

Role of Transrectal Ultrasound and Elastography in the Diagnosis of Prostate Lesions

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