Hypofractionated versus conventionally fractionated radiotherapy for patients with prostate cancer (HYPRO): acute toxicity results from a randomised non-inferiority phase 3 trial

Abstract

The Dutch Cancer Society.

Dosimetric comparison of intensity‐modulated radiotherapy and volumetric‐modulated arc radiotherapy in patients with prostate cancer: a meta‐analysis

“…However, some toxic effects of adjacent non‐cancerous tissues, including gastrointestinal and genitourinary adverse effects, have been induced 3 , 4 . Thus, increasing the dose of planning target volume (PTV) while minimizing irradiation of surrounding healthy tissue becomes the main focus of developing RT techniques.…”

Use of hydrogel spacer for improved rectal dose-sparing in patients undergoing radical radiotherapy for localized prostate cancer: First Canadian experience

“…7 Based on this and other studies, [8][9] mild hypofractionation has become an accepted and increasingly adopted dose schedule at ours and many other institutions. Nonetheless, in approximately 10-25% of cases, strict rectal dose-constraints are not met, generating a concern for increased risk of late toxicities, particularly in the context of higher dose per fraction.…”

Early toxicity of hypofractionated radiotherapy for prostate cancer

“…n=number of patient in hypofractionated arm; N=number of fraction; d=particular dose; d=total dose; eQd2=dose equivalent to 2Gy fractionation; Na=not available aluwini et al 23 recently published results of phase iii randomized study, enrolling patients with intermediate or high risk prostate cancer. 391 patients received 39x2.0 Gy, five fractions per week and 403 patients received 19x3.4 Gy, three fractions per week.…”