Hypogeusia and zinc depletion in chronic dialysis patients

Atkin-Thor, E; Goddard, Benjamin; O'Nion, J V; Stephen, Robert L.; Kolff, W J

doi:10.1093/ajcn/31.10.1948

Cited by 171 publications

(55 citation statements)

References 8 publications

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“…AtkinThortx al. [7] demonstrated an improvement in taste acuity following oral zinc sulfate ther apy in hemodialysis patients with low serum zinc levels. The cause and clinical signifi cance of low serum zinc in hemodialysis pa tients has not yet been established.…”

Section: Introductionmentioning

confidence: 95%

Zinc Transfer during Hemodialysis in Chronic Renal Failure Patients

Hosokawa¹,

Kohira

Imai

et al. 1983

Blood Purif

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We examined zinc transfer during hemodialysis and serum zinc concentrations of hemodialyzed patients. 10 outpatients were studied during a single dialysis and 6 hospitalized patients were monitored during a week-long series of dialysis. Serum zinc concentrations increased significantly by diffusion and hemoconcentration after 5-hour dialysis. In 6 hospitalized patients, the daily protein and calorie intake were measured to examine the relationship between serum zinc and diet. We found a good correlation between serum zinc concentrations and total serum protein or daily calorie intake.

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Section: Introductionmentioning

confidence: 95%

Zinc Transfer during Hemodialysis in Chronic Renal Failure Patients

Hosokawa¹,

Kohira

Imai

et al. 1983

Blood Purif

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“…Patients with CRF have low plasma zinc concentrations [5,6], al though this may not necessarily be indicative of zinc de ficiency. Recently, Atkin-Thor et al [7] and O'Nion et al [8] reported that chronic hemodialysis patients had hypo geusia. associated with low serum, red blood cell, and hair zinc concentrations.…”

Section: Introductionmentioning

confidence: 99%

Taste, Smell and Zinc Metabolism in Patients with Chronic Renal Failure

Vreman

Venter

Leegwater

et al. 1980

Nephron

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Taste and smell acuity, and zinc concentrations in blood, plasma, red blood cells, and hair were determined in male patients with end stage renal disease (n = 7), male (n – 20) and female (n = 6) patients on maintenance hemodialysis (HD), and male (n = 23) and female (n = 25) control groups. Taste acuity for salt (NaCl), sweet (sucrose), acid (HCl) and bitter (urea) in all 3 patient groups was lower than in the appropriate control group. These differences were significant only for sucrose (male dialysis, p < 0.05), HCl (male uremics not on dialysis, p < 0.01; male dialysis, p < 0.01; and female dialysis, p < 0.05) and urea (male dialysis, p < 0.01). Smell perception was impaired (not significantly) for the male patient groups, but slightly improved (not significantly) for the female patient group. Red blood cell and hair Zn⁺⁺ concentrations were elevated for the male HD group (p < 0.001). The plasma zinc concentration was significantly lowered for the male patient groups (p < 0.05). Age showed a negative correlation with pyridine, NaCl, sucrose, and HO mean detection levels for both male HD patients and control groups. Sensitivity to urea also decreased with age for male HD patient groups, but increased for the male control group. Blood and RBC Zn⁺⁺ concentrations increased and plasma and hair Zn⁺⁺ decreased with age for the male HD patients and the male control group. No correlation was observed between Zn⁺⁺ concentrations and taste and smell mean detection levels.

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“…The decreased gustin levels may also relate to an inability to absorb, transport, or store zinc. Approximately one-quarter of patients with taste and smell dysfunction have been found to exhibit zinc-malabsorption (31), and patients with chronic renal disease exhibit hypogeusia, hypogonadism, and other signs of zinc deficiency (32)(33)(34)(35)(36)(37)(38), which have been corrected with exogenous zinc therapy in controlled clinical trials (36)(37)(38).…”

Section: Methodsmentioning

confidence: 99%