Hypoglycaemia among Insulin-Treated Patients with Diabetes: Southeast Asia Cohort of IO HAT Study

Abstract

Objective: To provide real-world data on hypoglycaemia incidence in patients with type 1 (T1D) or type 2 diabetes (T2D) from the Southeast Asian cohort of the International Operations Hypoglycaemia Assessment Tool (IO HAT) study.Methodology: IO HAT was a non-interventional, multicentre, 6-month retrospective and 4-week prospective study of hypoglycaemic events among insulin-treated adults with T1D or T2D, including four countries in Southeast Asia (Singapore, Philippines, Indonesia, and Bangladesh). Data were collected using a two-part self-assessment questionnaire (SAQ1 for retrospective and SAQ2 for prospective). The primary endpoint was the percentage of patients experiencing at least one hypoglycaemic event during the 4-week prospective observational period (ClinicalTrials.gov Identifier: NCT02306681).Results: A total of 2594 patients completed SAQ1. Nearly all patients reported experiencing any hypoglycaemic event in the 4-week prospective period (T1D, 100%; T2D, 97.3%), with all patients reporting higher rates in the prospective versus retrospective period. Severe hypoglycaemia was also reported higher prospectively (57.2% and 76.9%) than retrospectively (33.9% and 12.2%) in both T1D and T2D, respectively. Nocturnal hypoglycaemia was reported higher retrospectively than prospectively. Conclusion:Incidence of any and severe hypoglycaemia in the Southeast Asian cohort of IO HAT was higher prospectively versus retrospectively, suggesting hypoglycaemia has previously been under-reported in this region.

Hypoglycemia Among Type 1 Diabetes Patients After Insulin Use in Southwest Ethiopia

“…This study was in line with 50% of the RECAP-DM study in Argentina (35). This finding was lower than 86.7% in Debre Markos Referral Hospital (5), 88% in Tikur Anbessa Specialized Hospital (23), and 94.3% in St. Paul's Hospital Millennium Medical College (22) studies in Ethiopia and 91.7% from HAT study in Brazil (36), 97.1% in Colombia (37), 97.4% from an international survey in nine countries (38), and 100% from the Southeast Asia cohort of IO HAT study (39). The variation observed between this and other studies may be due to the operational definition used.…”

Changes in quality of life following hypoglycaemia in adults with type 2 diabetes: A systematic review of longitudinal studies

“…Abstract and title screening excluded 12,096 records, and full‐text screening eliminated 460 records, leaving 15 studies 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 that satisfied inclusion criteria. Backward and forward citation searches of these studies identified 3 additional studies, 35 , 36 , 37 and hand searches identified 2 studies, 38 , 39 resulting in 20 total studies selected for extraction and synthesis (Figure 1 ).…”

“…Two studies assessed impairment in the workplace among participants from Eastern Europe 23 and Southeast Asia. 38 Over a 30‐day period, approximately 3% of adults with type 2 diabetes reported having been absent from work, and 2%–5% reported having left work early, as a direct consequence of hypoglycaemia. Impairment during non‐work activities (e.g.…”

“…Regarding facets in the physical domain of QoL, approximately 2%–5% of adults with type 2 diabetes report difficulty performing everyday tasks both in and out of the workplace each month as a direct consequence of hypoglycaemia—impacts similar to those reported by adults with type 1 diabetes. 23 , 38 Hypoglycaemia also leads to diminished energy, but only among those experiencing frequent episodes (four or more per month). Again, this impact matches type 1 diabetes research.…”

“…Abstract and title screening excluded 12,096 records, and full-text screening eliminated 460 records, leaving 15 studies [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] that satisfied inclusion criteria. Backward and forward citation searches of these studies identified 3 additional studies, [35][36][37] and hand searches identified 2 studies, 38,39 resulting in 20 total studies selected for extraction and synthesis (Figure 1). These 20 studies, published between 1998 and 2020, sampled adults with type 2 diabetes (N = 50,429) from more than 20 countries (Table 1).…”