Hypoglycaemic activity of &lt;i&gt;Vernonia amygdalina&lt;/i&gt; (chloroform extract) in normoglycaemic and alloxan-induced hyperglycaemic rats

Gyang, Steven Samuel; Nyam, Davou Dung; Sokomba, Elijah

doi:10.4314/jpb.v1i1.32050

Cited by 16 publications

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“…[7] It is reported that about 800 plants may possess antidiabetic potential. [8] Some plants reported to have antidiabetic or hypoglycemic activity are Vernonia amygdalina, [9][10][11] Tecoma stans (L.) Juss ex Kunth, [12] Rauwolfi a vomitoria, umbelliferone from bitter orange (Citrus aurantium), [13,14] Polygonatum odorantum [15] and Hericium erinaceus. [16] The plant Cucumis metuliferus (Curcubitaceae) is a monoecious annual herb with staminate flowers that grows wild.…”

Section: Introdutionmentioning

confidence: 99%

Glycosides fraction extracted from fruit pulp of Cucumis metuliferus E. Meyer has antihyperglycemic effect in rats with alloxan-induced diabetes

Gotep¹

2011

J Nat Pharm

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Introduction:The antihyperglycemic property of glycosides extracted from Cucumis metuliferus was tested in albino rats with alloxan-induced diabetes. Materials and Methods: Five groups of rats labeled A to E, each group containing fi ve rats, were made diabetic by intraperitoneal (i.p.) administration of alloxan 150 mg/kg. The groups A to E were and treated with normal saline, 25 mg/kg extract, 50 mg/kg extract, 100 mg/kg extract, and chlorpropamide 100 mg/kg, respectively. The blood glucose concentrations (BGC) of the rats were measured using a glucometer. Results: The groups treated with the extract (25-100 mg/kg) showed statistically signifi cant dose-dependent reductions in BGC. The percentage reductions in blood glucose concentration after 24 h were 56.0%, 51.1%, 65.2%, and 68.8% for rats treated with 100 mg/kg chlorpropamide, 25 mg/kg extract, 50 mg/kg extract, and 100 mg/kg extract, respectively. Conclusion: The glycosides from C. metuliferus possess antihyperglycemic activity in albino rats with alloxan-induced diabetes.

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Section: Introdutionmentioning

confidence: 99%

Glycosides fraction extracted from fruit pulp of Cucumis metuliferus E. Meyer has antihyperglycemic effect in rats with alloxan-induced diabetes

Gotep¹

2011

J Nat Pharm

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“…Nothing has been scientifically reported about V. calvaona, inspite of its rich phytochemical and nutrient composition which contributes significantly to the dietary nutrient intake by the consuming populations of Eastern Nigeria and South Western Cameroun. Its popular sister species (V. amygdalina and V. tenoreana) have been thoroughly investigated with respect to human nutrition, glycaemic effect, lipidemic effect, antimalarial, anthelminthic, anti-diabetic and antitumorigenic activities (Gyang et al, 2004;Ojiako & Nwanjo, 2006;Igile et al, 1995;Ebong et al, 2008). Considerable attention had been focused on the pharmacodynamic properties of V. amygdalina especially its hypoglycaemic activities (Ogbuokiri et al, 1989;Akah & Okafor, 1992).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical, Proximate and Nutrient Composition of Vernonia calvaona Hook (Asterecea): A Green-Leafy Vegetable in Nigeria

Igile¹,

Iwara²,

Mgbeje³

et al. 2013

JFR

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The leaf of Vernonia calvaona was analysed for its phytochemical, proximate, anti-nutrient, mineral elements and vitamin compositions using standard analytical procedures. Flavonoids (7.07 ± 0.43%) were the most dominant plant secondary compound, followed by steroidal saponins (4.42 ± 0.23%), phenolic compounds (3.19 ± 0.05%), and carotenoids (1.62 ± 0.11%). Alkaloids (1.26 ± 0.13%), and sesquiterpene lactones (1.64 ± 0.13%) were also present in the plant. The proximate analysis of the fresh leaf gave a carbohydrate content of 20.80± 0.67 mg/100 g, with a corresponding reducing sugar content of 8.56 ± 0.06 mg/100 g. The sample also gave a protein content of 19.80 ± 0.61 mg/100 g and fat content of 4.17 ±0.15 mg/100 g respectively. The total fatty acid content of the plant was 3.57 ± 0.52 mg/100 g. Overall the green-leafy vegetable of Vernonia calvaona which is usually eaten raw and fresh contains a very balanced nutrient composition and provides a total metabolising energy value of 844.49 ± 6.19 KJ/100 g. The plant has a crude fibre content of 7.63 ± 0.22 mg/100 g and an ash content of 10.67 ± 0.33 mg/100 g respectively. The anti-nutrient levels, including oxalates (0.34 ± 0.04 mg/100 g), phytates (0.94 ± 0.04 mg/100 g) and cyanates (0.09 ± 0.01 mg/100 g) were low compared to many known vegetables. The leaf is rich in vitamins (Vit C 11.33 ± 0.88, Vit A 0.61 ± 0.01 and Vit E 0.99 ± 0.13 mg/100 g). The leaf is also rich in vitamins B₁, B₂, B_6,niacin and folic acid. The mineral profile of the leaf sample is also impressive, and includes some key elements such as, Fe, Zn, Ca, Na, K, Mg, P and Se. It may be concluded that the leaves of V. calvaona contribute to nutrient intake by the consuming populations in Nigeria and can serve as an antimalarial, antidiabetic, fertility agent, anti-cancer, anti-ulcer and cardioprotective agent.

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“…belongs to the Compositae family and grows extensively in a range of ecological zones in tropical Africa (Farombi, 2003). The antihyperglycemic action of the plant (NimeniboUadia, 2003;Akah et al, 2004) hypoglycermic effect (Gyang et al, 2004); hypolipidemic and antihyperlipidemic action of the aqueous leaf extract (Atangwho, et al, 2007a) and its protective effect on kidneys of diabetic rats (Atangwho, et al, 2007b) have been reported. On the other hand Azadirachta indica A. Juss belongs to the family Meliacae and the hypoglycemic action of its leaves, stem, and bark and seed oil have been articulated in a review by Biswas et al (2002).…”

Section: Introductionmentioning

confidence: 99%

Effect of co-administration of extracts of Vernonia amygdalina and Azadirachta indica on lipid profile and oxidative stress in hepatocytes of normal and diabetic rats

Ebong¹,

Atangwho²

2011

ABJNA

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Effect of combined administration of extracts of Vernonia amydalina (VA) and Azadirachta indica (AI) on oxidative stress indices and serum lipid profile of normal and diabetic rats was evaluated. Result indicated a significant decrease (p<0.05) in catalase (CAT) activity, but non-significant decreases (p>0.05) in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, and in the extent of lipid peroxidation non-significant increase (p>0.05) in malondialdehyde (MDA) concentration of untreated diabetic rats relative to the normal control. Treatment with combined extracts of VA and AI caused significant elevation in GPx, SOD and CAT activities, and reduction in MDA concentration in hepatocytes, hence antioxidant activity. This antioxidant potential was also demonstrated in normal rats which received the treatment. The combined extracts also caused mild increase and decrease in serum high density lipoprotein (HDL) cholesterol and triacylglycerol concentrations, but a respective significant (p<0.05) decrease and increase in serum total cholesterol (TC) and anti-atherogenic index (HDL/TC) when compared to diabetic control. Co-administration of extracts of VA and AI may positively modulate the antioxidant defense system and prevent atherosclerosis in diabetes.

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Hypoglycaemic activity of <i>Vernonia amygdalina</i> (chloroform extract) in normoglycaemic and alloxan-induced hyperglycaemic rats

Cited by 16 publications

References 0 publications

Glycosides fraction extracted from fruit pulp of Cucumis metuliferus E. Meyer has antihyperglycemic effect in rats with alloxan-induced diabetes

Glycosides fraction extracted from fruit pulp of Cucumis metuliferus E. Meyer has antihyperglycemic effect in rats with alloxan-induced diabetes

Phytochemical, Proximate and Nutrient Composition of Vernonia calvaona Hook (Asterecea): A Green-Leafy Vegetable in Nigeria

Effect of co-administration of extracts of Vernonia amygdalina and Azadirachta indica on lipid profile and oxidative stress in hepatocytes of normal and diabetic rats

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