Hypoglycaemic and antidiabetic effect of root extracts of <I>Ceiba pentandra</I> in normal and diabetic rats

Abstract

The effect of the root bark extract of Ceiba pentandra (Linn) in normal and streptozotocin-induced diabetic rats was studied. Blood glucose levels were determined after oral administration of graded doses of C. pentandra (40, 75,150 and 300 mg/kg) in fasted normal and diabetic groups. In both groups, 40 and 75 mg/kg of the extract, significantly reduced blood glucose levels 8 h after administration, which was consistent and time-dependent. C. pentandra at the lower dose of 40mg/kg produced bloodglucose-lowering effect of 40.0% and 48.9%, in normal and diabetic rats respectively when compared with control rats. The higher doses of 150 and 300 mg/kg did not affect significantly the blood glucose levels. In multiple dose studies, the diabetic rats were treated orally by gavages, twice a day for 3 days. On day 3, C. pentandra (40 and 75mg/kg) significantly decreased blood and urine glucose levels as compared to initial values. The 14 h fasting blood glucose concentration was lowered by 59.8 % and 42.8% at the doses of 40 and 75 mg/kg and the corresponding urine glucose levels reductions were 95.7% and 63.6%, respectively. The results indicated that C. pentandra possessed hypoglycaemic effect. The plant extract was capable of ameliorating at lower doses, hyperglycaemia in streptozotocin-induced diabetic rats and could be a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

Hypoglycemic and in vitro antioxidant activity of ethanolic extracts of Ficus racemosa Linn. fruits

“…The extracts, at 200 mg/kg body weight produced maximum reduction of 41.91% on day 14 whereas inhibition of 45.49% was found for metformin on day 14 as a peak. These observations suggest that EEFR might possess insulin like effect on peripheral tissues either by promoting glucose uptake and metabolism or inhibiting hepatic gluconeogenesis since alloxan treatment causes permanent destruction of β- cells (Pari et al, 2002;Djomeni et al, 2006). Our findings also support with the similar observations reported earlier (Jahan et al, 2009) on the effect of ethanolic fruit extracts of Ficus racemosa Linn.…”

Effect of solvent extracts of Colatropis gigantea leaf on oxidative parameters in diabetic rabbits

“…The acute hypoglycaemic effect of glibenclamide has been shown to be the stimulation of production of the residual β-cells of the pancrease in addition to enhancement of glucose utilization (Moller, 2001). This suggests that the extracts may have similar mechanism of action with glibenclamide and may in addition possess an insulinomimetic effect on peripheral tissues either by promoting glucose uptake and metabolism or inhibiting hepatic gluconeogenesis (Djomeni et al, 2006). This postulation correlates with that of Farjou et al (1987) on the work with Artemisia extract.…”

Influence of addition of Raftiline HP® on the growth, proteolytic, ACE- and α-glucosidase inhibitory activities of selected lactic acid bacteria and Bifidobacterium

“…One therapeutic approach to decrease postprandial hyperglycemia is to retard the absorption of glucose by inhibiting enzymes such as a-glu (Kim, Jeong, Wang, Lee, & Rhee, 2005). Much of the work related to a-glu inhibition has involved the use of plant extracts and some traditional foods (Djomeni et al, 2006;Fujita, Yamagami, & Ohshima, 2003). Limited work has been conducted on the anti-diabetic potential of LAB (Yadav, Jain, & Sinha, 2007).…”