Hypoglycaemic effect of Helicteres isora bark extract in rats

Ganesan, Kumar; Banu, Gani Sharmila; Murugesan, A.; Pandian, M. Rajasekara

doi:10.1016/j.jep.2006.05.007

Cited by 35 publications

(26 citation statements)

References 17 publications

(17 reference statements)

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“…An ethanol extract of the root caused significant reduction in plasma glucose, triglyceride, and insulin levels at 300 mg/kg dose after 9 days of administration to insulin resistant and diabetic db/db mice [11]. An aqueous extract of the bark showed significant antidiabetic and hepatoprotective effects in streptozotocininduced diabetic rats [12,13]. Earlier, we reported that the aqueous ethanol and butanol extracts of H. isora root produced significant (30.35% and 48.86% protection, respectively) antihyperglycemic activity in alloxaninduced diabetic rats at a dose of 250 mg/kg after 3 h of treatment [14].…”

Section: Introductionmentioning

confidence: 96%

Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action

Venkatesh

Reddy

et al. 2010

J Nat Med

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The antihyperglycemic and hypolipidemic activities of Helicteres isora Linn. (Sterculiaceae) root extracts were investigated in alloxan-induced diabetic rats and a possible mechanism of the blood glucose lowering action was studied. Alloxan-induced diabetic rats experienced 69.13 and 51.14%, 22.60 and 21.89%, 30.12 and 19.96%, and 50.05 and 34.29% reduction in blood glucose, total cholesterol, triglycerides, and urea levels following oral administration of butanol and aqueous ethanol extracts of H. isora root, respectively, at 250 mg/kg for 10 days. The beneficial effects of these extracts were supported by evidence from histological examinations of the liver, pancreas, and kidney. Following the treatment with both extracts, the degenerative changes caused by alloxan in pancreatic cells were restored, particularly with the butanol extract. Histological examination convincingly showed the restoration of pancreatic islets, kidney glomeruli, and liver to its normal size. These results suggest that H. isora roots possess antidiabetic principles and can be useful for treatment of diabetes.

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Section: Introductionmentioning

confidence: 96%

Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action

Venkatesh

Reddy

et al. 2010

J Nat Med

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“…Group V: Diabetic rats given HIBe (100 mg=kg b.w.) (Kumar et al, 2006a) in aqueous solution daily using an intragastric tube for 5 weeks. Group VI: Diabetic rats given HIBe (200 mg=kg b.w.)…”

Section: Experimental Designmentioning

confidence: 99%

“…Group VII: Diabetic rats given tolbutamide (250 mg=kg b.w.) in aqueous solution daily using an intragastric tube for 5 weeks (Kumar et al, 2006a).…”

Section: Experimental Designmentioning

confidence: 99%

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Effect ofHelicteres isora. Bark Extracts on Brain Antioxidant Status and Lipid Peroxidation in Streptozotocin Diabetic Rats

Ganesan

Banu²,

Pandian³

2007

Pharmaceutical Biology

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The current study investigated the effect of the aqueous extract of Helicteres isora L (Sterculiaceae) bark on oxidative stress in the brains of rats during diabetes. The aqueous extract of H. isora bark was administered orally (100, 200 mg=kg b.w.) and the effect of the extract on blood glucose, plasma insulin, and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and reduced glutathione (GSH) were estimated in streptozotocin (STZ) diabetic rats. Tolbutamide was used as the standard reference drug. A significant increase in the activities of plasma insulin, SOD, CAT, GPx, GST, and GSH were observed in the brain on treatment with 100 and 200 mg=kg b.w. of H. isora bark extract (HIBe) and tolbutamide for 5 weeks. Both treated groups (bark extract and drug) showed a significant decrease in TBARS and hydroperoxides formation in brain, suggesting its role in protection against lipid peroxidation-induced membrane damage. These findings suggest a possible antiperoxidative role of H. isora bark extract that may be used for therapeutic purposes.

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“…Several species of this genus have been used in folk medicine, for instance, the root of H. isora has been used for the treatment of empyema, stomach affection, intestinal infection, and diabetes [2], H. ovata and H. sacarolha have been used for the treatment of syphilis and as a depurant [3], and the root of H. hirsuta has been used for the treatment of uterus pain [4]. Biological studies of several species of this genus have demonstrated that the extract of H. isora showed antinociceptive, antidiabetic, hypolipidemic, and hypoglycaemic activities [2] [5] [6], the extract of H. hirsuta showed cytotoxic activities [7], and the extract of H. gardneriana displayed antiprotozoal activity [3]. Previous phytochemical studies of Helicteres plants have led to the isolation of lignans, neolignans, cucurbitacins, flavonoids, and rosmarinic acid derivatives [7] [8 -12].…”

mentioning

confidence: 99%

Cytotoxic Triterpenoids from the Root Bark of Helicteres angustifolia

Pan¹,

Chen²,

Lee³

et al. 2008

Chemistry & Biodiversity

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Three new triterpenoids, 3beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3beta-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.

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Hypoglycaemic effect of Helicteres isora bark extract in rats

Cited by 35 publications

References 17 publications

Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action

Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action

Effect ofHelicteres isora. Bark Extracts on Brain Antioxidant Status and Lipid Peroxidation in Streptozotocin Diabetic Rats

Cytotoxic Triterpenoids from the Root Bark of Helicteres angustifolia

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