Hypoglycemic Activity of Gymnema sylvestre Extracts on Oxidative Stress and Antioxidant Status in Diabetic Rats

Kang, Myung‐Hwa; Lee, Min Sun; Choi, Mi‐Kyeong; Min, Kwan-Sik; Shibamoto, Takayuki

doi:10.1021/jf205086b

Cited by 80 publications

(58 citation statements)

References 36 publications

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“…Ethanol extract from G. sylvestre leaves showed antihyperglycemic activity and improved the antioxidant status in diabetic rats [48]. The extract also exhibited strong antioxidant activity in invitro assays, including thiobarbituric acid (TBA), superoxide dismutase (SOD)-like, and 2,2-azinobis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) assays.…”

Section: Gymnema Sylvestrementioning

confidence: 99%

“…TBA assay is associated with lipid peroxidation because of the presence of an intermediary of the process (malondialdehyde), whereas the other two substances are involved in free radical uptake. The authors attribute the antioxidant properties to the high amounts of phenolic components in the extract [48].…”

Section: Gymnema Sylvestrementioning

confidence: 99%

“…Furthermore, liquid chromatography and mass spectrometry (LC/MS) experiments showed that the extract has high quantities of gymnemagenin and gymnemic acids; these components may be responsible for the antihyperglycemic effect. It is also possible that the antihyperglycemic potential of the plant is due to an increase in insulin release, which is evident by the elevated level of plasma insulin in diabetic rats [48].…”

Section: Gymnema Sylvestrementioning

confidence: 99%

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Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Section: Gymnema Sylvestrementioning

confidence: 99%

Section: Gymnema Sylvestrementioning

confidence: 99%

Section: Gymnema Sylvestrementioning

confidence: 99%

See 1 more Smart Citation

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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“…They also demonstrated the antioxidant activity by increasing the levels of superoxide dismutase, glutathione, and catalase in rats through in vivo studies. 19 Kang et al 20 proved the role of antioxidants from G. sylvestre in diabetic rats using ethanolic extracts. Using several antioxidant assays, eg, thiobarbituric acid assay with slight modifications, egg yolk lecithin or 2-deoxyribose (associated with lipid peroxidation) assay, superoxide dismutase-like activity assay, and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) assay.…”

Section: Introductionmentioning

confidence: 99%

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

Arunachalam¹,

Arun²,

Annamalai³

et al. 2014

IJN

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Background Gymnema sylvestre is an ethno-pharmacologically important medicinal plant used in many polyherbal formulations for its potential health benefits. Silver nanoparticles (SNPs) were biofunctionalized using aqueous leaf extracts of G. sylvestre . The anticancer properties of the bioactive compounds and the biofunctionalized SNPs were compared using the HT29 human adenoma colon cancer cell line. Methods The preliminary phytochemical screening for bioactive compounds from aqueous extracts revealed the presence of alkaloids, triterpenes, flavonoids, steroids, and saponins. Biofunctionalized SNPs were synthesized using silver nitrate and characterized by ultraviolet–visible spectroscopy, scanning electron microscopy, energy-dispersive X-ray analysis, Fourier transform infrared spectroscopy, and X-ray diffraction for size and shape. The characterized biofunctionalized G. sylvestre were tested for its in vitro anticancer activity against HT29 human colon adenocarcinoma cells. Results The biofunctionlized G. sylvestre SNPs showed the surface plasmon resonance band at 430 nm. The scanning electron microscopy images showed the presence of spherical nanoparticles of various sizes, which were further determined using the Scherrer equation. In vitro cytotoxic activity of the biofunctionalized green-synthesized SNPs (GSNPs) indicated that the sensitivity of HT29 human colon adenocarcinoma cells for cytotoxic drugs is higher than that of Vero cell line for the same cytotoxic agents and also higher than the bioactive compound of the aqueous extract. Conclusion Our results show that the anticancer properties of the bioactive compounds of G. sylvestre can be enhanced through biofunctionalizing the SNPs using the bioactive compounds present in the plant extract without compromising their medicinal properties.

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“…Diabetes mellitus(DM), which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy [1]. DM, characterized as genetically based predisposition and dietary indiscretion [2] is ranked seventh among the leading causes of death and third when it's fatal complications are taken into account [3,4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

Bhusal

Jamarkattel

Shrestha

et al. 2014

JCDR

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Objective: The objectives of the study are to screen out various phytochemicals and to evaluate the antioxidant and antidiabetic potential of the stem bark of Holarrhena pubescens Wall (Holarrhena antidysenterica). Materials and Methods:The antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity where ascorbic acid was taken as positive control. The antioxidant property was later exploited and the methanolic extract of plant was tested for antihyperglycemic activity in glucose overloaded hyperglycemic mice. The extract was tested for its hypoglycemic activity at two-dose levels, 250 and 500 mg/kg respectively where Glipizide 5 mg/kg was taken as standard reference drug. All results are presented as mean ± SD (Standard Deviation). Significant differences between experimental groups were determined by Student's t-test. Results:The methanolic and water extract showed strong antioxidant activity with inhibition of more than 90% DPPH free radicals at the concentration of 100µg/mL. The hypoglycemic activity of methanolic extract on glucose tolerance test were significant (p <0.05) for the effects of 500 mg/kg after 120 min of treatment and (p <0.01) for 250 mg/kg of extract after half hour of treatment compared to control.

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Hypoglycemic Activity of Gymnema sylvestre Extracts on Oxidative Stress and Antioxidant Status in Diabetic Rats

Cited by 80 publications

References 36 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

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