Hypoglycemic Activity of Curculigo latifolia on Insulin and Glucose Uptake Activities in in vitro

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

“…This was possibly because some bioactive compounds in the root extract were absent from the fruit extract, which lowered the efficacy level where fewer synergistic interactions occurred. 15 A similar result was also seen in the study by Ishak and Zabidi, 24 where the fruit and root extracts displayed promising antidiabetic effects. However, in this study, the leaf extract of C. latifolia showed a lower potential in activity, which may be due to the lack of some active components.…”

“…20 The unique features of these compounds, such as their functional groups, configuration, substitution, and amount of hydroxyl groups, essentially facilitate protection against oxidative damage by radical neutralization, iron binding, and reducing power capacities. 89 The report by Ishak and Zabidi 24 is consistent with Ooi et al, 20 where high contents of flavonoids and phenolics in the extracts also corresponded to antioxidant activities. The study demonstrated that the root extract of C. latifolia with high phenolic and flavonoid contents under subcritical water extraction showed DPPH radical scavenging activities of 128.70 mg Trolox equivalents/g sample and ABTS scavenging activity of 66.78 mg Trolox equivalents/g sample.…”

“…The study demonstrated that the root extract of C. latifolia with high phenolic and flavonoid contents under subcritical water extraction showed DPPH radical scavenging activities of 128.70 mg Trolox equivalents/g sample and ABTS scavenging activity of 66.78 mg Trolox equivalents/g sample. 24 Moreover, in the findings of Nur et al, 62 different extracts of C. latifolia roots, stems, and leaves reported varying antioxidant capacities, in ABTS study, ethanol and ethyl acetate extracts of C. latifolia exerted the most significant activity by contributing proton radicals to free radical compounds. Meanwhile, β-carotene bleaching assay demonstrated that ethyl acetate extracts of C. latifolia roots, stems, and leaves could effectively prevent β-carotene decomposition upon oxidation of linoleic acid to hydroperoxide compared to the other extracts.…”

“…23 It is also known to have several other medicinal properties, such as hemorrhoids and asthma. 24 Additionally, previous findings have also suggested that the phytochemicals found in C. latifolia exhibit hepatitis B virus inhibitor, anti-diabetic, anti-arthritic, anti-tumor, anti-inflammatory, estrogenic, and sexual behavior-modifying activities. 18,25 Additionally, C. latifolia has also been shown to be used for taste modifying activities and as an alternative to low-calorie sweeteners owing to its composition of sweet proteins known as curculin or neoculin.…”