Hypoglycemic activity of Iraqi<i>Rheum ribes</i>root extract

Naqishbandi, Alaadin M.; Josefsen, Knud; Pedersen, M. E.; Jäger, Anna K.

doi:10.1080/13880200902748478

Cited by 30 publications

(11 citation statements)

References 6 publications

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“…In light of our study, among the effective extracts, Pistacia atlantica had the inhibitory superiority indicating that it could act as "starch blocker" and, thus, an "effective antiobesity agent" (Kotowaroo et al, 2006) The antioxidant activity of chloroform and methanol extracts of rhubarb (Rheum ribes), which are used for medicinal purposes and are consumed as vegetable, was demonstrated (Ozturk et al, 2007). In addition Rheum ribes insulin releasing activity was demonstrated in vitro, evoking a significant hypoglycemic effect in fasted healthy mice over 24 h periods (Naqishbani et al, 2009). The hypoglycemic effect in alloxan-diabetic animals is mentioned as well (Ozbek et al, 2004).…”

Section: Discussionmentioning

confidence: 94%

In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine

Kasabri¹,

Afifi

Hamdan

2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 94%

In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine

Kasabri¹,

Afifi

Hamdan

2011

Journal of Ethnopharmacology

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“…[17,19] Multiple studies have shown that R. Ribes roots have antidiabetic activity, including antihyperglycemic, insulin-releasing, and antiretinopathic activities. [20][21][22][23] Urtica Dioica (U. Dioica) is another medicinal plant, which belongs to the Urticaceae family. This plant is also famous for its use as a food ingredient and herbal drug.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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The prevalence of type 2 diabetes is increasing and considered a major cause of mortality in the world. Medicinal plants are a part of complementary and alternative medicine, which have wide use in the treatment of diabetes. Besides, combination therapy as an effective therapeutic strategy is highly recommended for controlling hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Rheum Ribes L. and Urtica Dioica L. extracts either alone or in combination on blood glucose level in type 2 diabetic rats. Diabetes was induced by single-dose administration of Streptozotocin (50 mg/kg) in rats. Diabetic rats were received intraperitoneal administration of R. Ribes aqueous extract (40 and 60 mg/kg), U. Dioica aqueous-alcoholic extract (100 and 200 mg/kg), and their combination for 21 days. The fasting blood glucose and body weight of rats were determined on 0, 7 th , 14 th , and 21 st days. The results showed that R. Ribes extract (40 and 60 mg/kg), U. Dioica extract (200 mg/kg), and their combination could significantly decrease the blood glucose level on 0, 7 th , 14 th , and 21 st days (P<0.0001). Only 200 mg/kg of U. Dioica had a positive effect on the bodyweight loss of diabetic rats (P<0.01). It can be concluded that Afghan R. Ribes and U. Dioica extracts and their combination have a hypoglycemic effect. However, their combinations do not show any synergic or antagonistic effects.

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“…The Polygonaceae family contains approximately 800 species, which are grouped into 30 genera and widely distributed all over the world (Stastn et al, 2010;Naqishbandi et al, 2009). The genus Rheum comprises about 103 species and is distributed in the temperate and sub-tropical regions (Rechinger and Schiman Czeika, 1968).…”

Section: Introductionmentioning

confidence: 99%