Hypoglycemic and Antidiabetic Effect ofPleurotus sajor-cajuAqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats

Abstract

Introduction. Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats. Materials and Methods. A single dose of 500, 750, or 1000 mg/kg of the PSC extract was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). The effective dose (750 mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles. Results. The dose of 750 mg/kg showed the most significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study (p < 0.05). In OGTT study, the same dose produced a maximum BG fall of 41.3% in normal rats and 36.5% in diabetic rats 3 hours after glucose administration. In 21-day study, treated diabetic rats showed significant improvement in terms of fasting BG, body weight, and urine sugar as compared to control diabetic rats. Conclusion. The study evidenced scientifically the beneficial use of PSC as an alternative medicine in diabetes management.

<p>Effect of <em>Pleurotus fossulatus</em> Aqueous Extract on Biochemical Properties of Liver and Kidney in Streptozotocin-Induced Diabetic Rat</p>

“…In another study, the researcher found that the estimated glomerular filtration rate (eGFR) is independently associated with serum uric acid, which is an indicator of the damaged kidney. 20 In our study, we found that the 500 mg concentration of PFA-extract can reduce the creatinine and BUN level effectively (no significant difference was found as compared with the drug control group) whereas uric acid level reduced significantly as compared with normal and diabetic control (but less effective than the drug control group) ( Figure 5).…”

An endophytic Schizophyllum commune Fr. exhibits in-vitro and in-vivo antidiabetic activity in streptozotocin induced diabetic rats

“…Antidiabetic β-glucans and polysaccharide-peptide have been isolated from species of Pleurotus (Kanagasabapathy et al 2012 ; Chen et al 2015 ). Although various basidiomycetes have been reported to exhibit antidiabetic activity (Jeong et al 2010 ; Ng et al 2015 ), this is the first report highlighting the therapeutic potential of S. commune in the management of diabetes.…”

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild DriedLentinus squarrosulus(Mont.) Mushroom in Rats

“…Proximate analysis of L. squarrosulus has shown high content of protein (9), minerals (potassium, magnesium, calcium, phosphorous and iron) (16), thiamine, riboflavin, folic acid, and dietary fibres with low fat and caloric value (9). The low fat and caloric content signifies that it could be useful as food or essential component of food for hyperlipidemic and diabetic patients (17). Phytochemicals present in fruiting bodies, mycelia and spores include phenolic (gallic acid, catechin, isoquercetin, kaempferol), saponins, flavonoids, tannins, alkaloids, quinolones, terpenes, and anthraquinones (18,19).…”