Hypoglycemic and Antilipidperoxidative Effects of a Polyherbal Formulation, Diakyur, in Experimental Animal Models

Joshi, Chandra Shekhar; Ekambaram, Sanmuga Priya; Venkataraman, S.

doi:10.1248/jhs.53.734

Cited by 13 publications

(4 citation statements)

References 23 publications

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“…The probable mechanism of action of the fractions is due to their Advanced molecular studies showed that methanol extract of black jamun plant modulate the expression of glucose transporter (Glut-4), peroxisome proliferator activator receptor gamma (PPARc) and phosphatidylinositol-3-kinase (PI3 kinase) comparable with insulin and rosiglitazone (Anandharajan et al 2006). Evaluation of black jamun containing antidiabetic poly herbal formulation in alloxan induced diabetic rats also showed significant hypoglycemic activity, positive glucose tolerance activity and reduced lipid peroxidation in various organs compared to that of the diabetic control animals (Joshi et al 2007). Meshram et al (2011) studied on hypoglycaemic action of black jamun seeds and concluded that the methanol extracts of black jamun seeds may act in a variety of diabetic conditions with or without functioning of pancreatic b-cells.…”

Section: Antidiabetic Activity From Fruit Part Extracts Of Black Jamumentioning

confidence: 99%

Antidiabetic and antioxidant functionality associated with phenolic constituents from fruit parts of indigenous black jamun (Syzygium cumini L.) landraces

et al. 2017

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Fruit phenolics are important dietary antioxidant and antidiabetic constituents. The fruit parts (pulp, seed, seed coat, kernel) of underutilized indigenous six black jamun landraces (Syzygium cumini L.), found in Gir forest region of India and differed in their fruit size, shape and weight, are evaluated and correlated with antidiabetic, DPPH radical scavenging and phenolic constituents. The a-amylase inhibitors propose an efficient antidiabetic strategy and the levels of postprandial hyperglycemia were lowered by restraining starch breakdown. The sequential solvent systems with ascending polarity-petroleum ether, ethyl acetate, methanol and water were performed for soxhlet extraction by hot percolation method and extractive yield was found maximum with methanolic fruit part extracts of six landraces. The methanolic extracts of fruit parts also evidenced higher antidiabetic activity and hence utilized for further characterization. Among the six landraces, pulp and kernel of BJLR-6 (very small, oblong fruits) evidenced maximum 53.8 and 98.2% inhibition of a-amylase activity, respectively. The seed attained inhibitory activity mostly contributed by the kernel fraction. The inhibition of DPPH radical scavenging activity was positively correlated with phenol constituents. An HPLC-PDA technique was used to quantify the seven individual phenolics. The seed and kernel of BJLR-6 exhibited higher individual phenolics-gallic, catechin, ellagic, ferulic acids and quercetin, whereas pulp evidenced higher with gallic acid and catechin as a-amylase inhibitors. The IC 50 value indicates concentration of fruit extracts exhibiting C50% inhibition on porcine pancreatic a-amylase (PPA) activity. The kernel fraction of BJLR6 evidenced lowest (8.3 lg ml-1) IC 50 value followed by seed (12.9 lg ml-1), seed coat (50.8 lg ml-1) and pulp (270 lg ml-1). The seed and kernel of BJLR-6 inhibited PPA at much lower concentrations than standard acarbose (24.7 lg ml-1) considering good candidates for antidiabetic herbal formulations. Keywords Syzygium cumini L. Á Fruit parts Á a-Amylase inhibition Á Antioxidant activity Á HPLC profile Á Herbal formulation Abbreviations DPPH 1,1-diphenyl-2-picrylhydrazyl NIDDM Non-insulin dependent diabetes mellitus WHO World health organization BJLR Black jamun landraces HPLC High-performance liquid chromatography DNSA Di-nitro salicylic acid PDA Photodiode array 2FCRD Two factor complete block randomized design PPA Porcine pancreatic a-amylase IC 50 50% inhibition of enzyme activity Electronic supplementary material The online version of this article (

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Section: Antidiabetic Activity From Fruit Part Extracts Of Black Jamumentioning

confidence: 99%

Antidiabetic and antioxidant functionality associated with phenolic constituents from fruit parts of indigenous black jamun (Syzygium cumini L.) landraces

et al. 2017

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“…This product may have a wide spectrum of biological functions. Furthermore, these polyherbal products may produce synergetic action due to multiple ingredients and contain potentially agonistic/antagonistic pharmacological agents within themselves 7 . The study by Mahajan et al showed the polyherbal of C. caesia, E. alsinoide, C. lanatus, G. sylvestre and T. cordifolia, W coagulans, and C bonduct antidiabetic effect to rats induced by alloxan at 400 mg/kg of body weight.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Analysis of the Antidiabetic Activity of Indonesian Polyherbal Formulation

Abdillah

Lestari

Monika

et al. 2021

JNR

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This study aims to prepare polyherbal formulations and also analyze the antidiabetic potentials of the prepared polyherbal in animals. The ethanol extracts of the leaves of Smallanthus sonchifolius, Stevia rebaudiana, Syzygium polyanthum, and Camellia sinensis were used in this study. The extracts of the aforementioned plants were prepared in the ratio of 2:1:1:1. The formulation was tested for antidiabetic activity in vitro through the inhibition of alpha-glucosidase and in vivo using alloxan-induced diabetes in mice. The polyherbal has an inhibitory effect with the IC50 value of 26.23 μg/mL compared to acarbose (control) was 17.02 μg/mL. The diabetic animals were observed to show an obvious decline in glucose level when compared with control (P< 0.001) after treatment.

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“…So, concluded that Diakyur at a dose of 1600 mg/kg p.o is safe for long term treatment in diabetic condition. 33 Diasulin A polyherbal formulation containing Cassia auriculata, Coccinia indica, Curcuma longa, Emblica officinalis, Gymnema sylvestre, Momordica charantia, Scoparia dulcis, Syzygium cumini, Tinospora cordifolia, Trigonella foenum graecum Previous Investigation suggest that controls the blood glucose level by increasing glycolysis and decreasing gluconeogenesis with a lower demand of pancreatic insulin than in untreated rats. This is possible, because it regulates the activities of hepatic glucose metabolic enzymes.…”

Section: Diabridmentioning

confidence: 99%

Diabetes and Antidiabetic Herbal Formulations: An Alternative to Allopathy

Kaur¹,

Valecha²

2014

European Journal of Medicine

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The present study was based on Diabetes, its cure & herbal products available in market. Diabetes mellitus is the most common endocrine disorder, affecting 16 million individuals in the United States and 200 million worldwide. Despite the use of advanced synthetic drugs for the treatment, use of herbal remedies is gaining higher importance because of synthetic drugs have drawbacks and limitations. The herbal drugs with antidiabetic activity are extensively formulated commercially because of easy availability, affordability and less side effects as compared to the synthetic antidiabetic drugs. Antidiabetic herbal formulations (AHF) are considered to be more effective for the management of diabetes. There are around 600 herbal drug manufacturers in India of which almost all manufacturers are developing AHF in addition to others. Till date no article is published to give detailed information of the herbal preparations on diabetes available in market. In this we illustrate about diabetes mellitus and its types, causes, sign and symptoms, complications, pathophysiology, diabetic medication, diabetic treatment, herbal diabetic cure, advantages of herbal medicines over allopathy and herbal formulations. Thus, this review article undertake the attempt for providing updated information on the type of diabetes and herbal formulations which will enhance the existing knowledge of the researchers.

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Hypoglycemic and Antilipidperoxidative Effects of a Polyherbal Formulation, Diakyur, in Experimental Animal Models

Cited by 13 publications

References 23 publications

Antidiabetic and antioxidant functionality associated with phenolic constituents from fruit parts of indigenous black jamun (Syzygium cumini L.) landraces

Antidiabetic and antioxidant functionality associated with phenolic constituents from fruit parts of indigenous black jamun (Syzygium cumini L.) landraces

Preliminary Analysis of the Antidiabetic Activity of Indonesian Polyherbal Formulation

Diabetes and Antidiabetic Herbal Formulations: An Alternative to Allopathy

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