Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice

Abstract

In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice.Methods: C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes lowjaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed. Results: Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities. Conclusion: These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

“…As it was also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities, a relevant relationship between antioxidant and antihyperglycemic effects of jaceosidin can be concluded. Jaceosidin could improve endoplasmic reticulum stress and attenuate insulin resistance via SERCA2b (sarco/endoplasmic reticulum Ca 2+ -ATPase 2b) upregulation in mice skeletal muscles [ 183 , 184 ].…”