Jaceosidin Ameliorates Insulin Resistance and Kidney Dysfunction by Enhancing Insulin Receptor Signaling and the Antioxidant Defense System in Type 2 Diabetic Mice

Park, Eunkyo; Hong, Kwangseok; Kwon, Byoung Mog; Kim, Yuri; Kim, Jung Hyun

doi:10.1089/jmf.2020.4739

Cited by 13 publications

(9 citation statements)

References 56 publications

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“…The mRNA levels of SOD1, SOD2, and Gpx, as well as SOD activity, were significantly decreased in the DOX group, and jaceosidin treatment was found to significantly, but not completely, prevent DOX-induced oxidative effects. These findings were consistent with a previous study showing that jaceosidin treatment increased the expression and activity of SOD in diabetic nephropathy [ 13 ]. These data suggest that jaceosidin may stimulate Nrf2-mediated downstream antioxidants to protect against DOX-induced damage.…”

Section: Discussionsupporting

confidence: 94%

“…However, these agents have adverse side effects, including weight loss and potentiation of doxorubicin-induced myelosuppression [ 24 ]. Jaceosidin has been shown to provide protection against several diseases [ 13 , 14 ]. Jaceosidin attenuated osteoarthritic cartilage damage by blocking I κ B degradation in mice [ 25 ], and it inhibited contact hypersensitivity in mice by downregulating IFN- γ signaling in T cells [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Jaceosidin has recently gained attention as a beneficial drug with low intrinsic toxicity. Moreover, jaceosidin has been demonstrated to possess antioxidative, anti-inflammatory, and immunosuppressive properties [ 11 – 13 ]. A recent study found that jaceosidin inhibits the inflammatory response and decreases complement levels in lipopolysaccharide- (LPS-) injected mice [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Protection against Doxorubicin‐Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway

Liu

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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The clinical use of doxorubicin (DOX) is largely limited by its cardiotoxicity. Previous studies have shown that jaceosidin has many biological activities. However, little is known about whether jaceosidin can attenuate DOX-related acute cardiotoxicity. Here, we investigated the therapeutic effects of jaceosidin on DOX-induced acute cardiotoxicity. Mice were intraperitoneally injected with a single dose of DOX to establish an acute cardiac injury model. To explore the protective effects, mice were orally administered jaceosidin daily for 7 days, with dosing beginning 2 days before DOX injection. The results demonstrated that jaceosidin dose-dependently reduced free radical generation, inflammation accumulation, and cell loss induced by DOX in cardiomyocytes. Further studies showed that jaceosidin treatment inhibited myocardial oxidative damage and the inflammatory response and attenuated myocardial apoptotic death, thus improving cardiac function in mice injected with DOX. The inhibitory effects of jaceosidin on DOX-related acute cardiotoxicity were mediated by activation of the sirtuin1 (Sirt1) signaling pathway. Jaceosidin lost its protective effect against DOX-related injury in Sirt1-deficient cardiomyocytes and mice. In conclusion, jaceosidin has protective potential in treating DOX-related cardiac injury through activation of the Sirt1 signaling pathway.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protection against Doxorubicin‐Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway

Liu

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…It also inhibited nuclear factor кB (NF- кB) activity and nitric oxide (NO) production, and it suppressed the expression of inducible nitric oxide synthase (iNOS) in LPS-induced RAW264.7 macrophages [ 224 ]. An in vivo experiment performed in 2020 by Park et al [ 225 ] demonstrated that dietary supplementation of mice with 92 increased the expression and activity of Cu and Zn-SOD (copper and zinc-superoxide dismutase), confirming its antioxidant properties. In this paper, the authors used diabetic mice, demonstrating reduced fasting blood glucose levels and insulin resistance through the upregulation of the insulin receptor downstream pathways in the liver and skeletal muscles, as evidence for the antidiabetic activity of jaceosidin.…”

Section: Biological Activitymentioning

confidence: 97%

Stevia Genus: Phytochemistry and Biological Activities Update

et al. 2021

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The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from S. rebaudiana, many other species belonging to the Stevia genus are considered medicinal and have been popularly used to treat different ailments. The members from this genus produce sesquiterpene lactones, diterpenes, longipinanes, and flavonoids as the main types of phytochemicals. Many pharmacological activities have been described for Stevia extracts and isolated compounds, antioxidant, antiparasitic, antiviral, anti-inflammatory, and antiproliferative activities being the most frequently mentioned. This review aims to present an update of the Stevia genus covering ethnobotanical aspects and traditional uses, phytochemistry, and biological activities of the extracts and isolated compounds.

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“…Administration of jaceosidin also attenuated the accumulation of glycation end products, decreased vascular endothelial growth factor-alpha protein levels in the kidney, and increased copper-and zinc-superoxide dismutase activity. Overall, jaceosidin has healing effects on diabetic nephropathy [42].…”

Section: Cirsimarin and Cirsimaritinmentioning

confidence: 98%

Therapeutic Single Compounds for Osteoarthritis Treatment

et al. 2021

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Osteoarthritis (OA) is an age-related degenerative disease for which an effective disease-modifying therapy is not available. Natural compounds derived from plants have been traditionally used in the clinic to treat OA. Over the years, many studies have explored the treatment of OA using natural extracts. Although various active natural extracts with broad application prospects have been discovered, single compounds are more important for clinical trials than total natural extracts. Moreover, although natural extracts exhibit minimal safety issues, the cytotoxicity and function of all single compounds in a total extract remain unclear. Therefore, understanding single compounds with the ability to inhibit catabolic factor expression is essential for developing therapeutic agents for OA. This review describes effective single compounds recently obtained from natural extracts and the possibility of developing therapeutic agents against OA using these compounds.

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Jaceosidin Ameliorates Insulin Resistance and Kidney Dysfunction by Enhancing Insulin Receptor Signaling and the Antioxidant Defense System in Type 2 Diabetic Mice

Cited by 13 publications

References 56 publications

Protection against Doxorubicin‐Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway

Protection against Doxorubicin‐Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway

Stevia Genus: Phytochemistry and Biological Activities Update

Therapeutic Single Compounds for Osteoarthritis Treatment

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