Hypoglycemic and Hypolipidemic Effects of Myrtus communis, Trachyspermum copticum and Ferula gummosa Essential Oils on Streptozotocin Induced Diabetic Rats

Karimlar, Saeedeh; Naderi, Asieh; Mohammadi, Farzad; Moslehishad, Maryam; Delrish, Elham; Khoshzaban, Ahad; Lashay, Alireza

doi:10.29252/nfsr.6.1.1

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…M. communis leaf aqueous extract was investigated for antidiabetic and antioxidant effects in diabetic rats induced with streptozotocin (STZ) and normal rats. MC leaf aqueous extract given at 150, 300, and 600 mg/kg significantly reduced ALT, AST, ALP in serum blood glucose and MDA levels, in STZ-induced diabetic rats when compared to controls groups ( P <0.05) (Karimlar et al 2019 ).…”

Section: Antidiabetic Effectmentioning

confidence: 96%

The therapeutic value of Myrtus communis L.: an updated review

Al-Snafi,

Teibo,

Shaheen

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Myrtus communis L. (Family: Myrtaceae) is naturally found in the western part of Asia, Southern Europe, and North Africa. It has been reportedly applied in pharmaceutical industry, traditional medicine, cosmetics, spices, and food. Pubmed, Google scholar, Web of Science, and Scopus were utilized to seek out relevant content concerning the therapeutic potential of M. communis. Subsequently, we conducted a review to identity noteworthy updates pertaining to M. communis. Myrtle berries, leaves, seeds, and essential oils are natural sources of several nutrients and bioactive compounds with marked health effects. The chemical analysis showed that M. communis contained oils, alkaloids, flavonoids, phenolics, coumarins, saponosides, tannins, quinines, and anthraquinones. A pharmacological investigation revealed that M. communis possessed anti-inflammatory, analgesic, antimicrobial, antiparasitic, antioxidant, antidiabetic, anticancer, antimutagenic, immunomodulatory, dermatological, cardiovascular, central nervous system, and gastrointestinal protective effects, among numerous other biological effects. This current review focused on the biochemical, pharmacological, therapeutic effects, and various biological activities of different parts of M. communis. It signifies that M. communis is a therapeutic plant with numerous applications in medicine and could be used as a drug isolate based on its safety and effectiveness.

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Section: Antidiabetic Effectmentioning

confidence: 96%

The therapeutic value of Myrtus communis L.: an updated review

Al-Snafi,

Teibo,

Shaheen

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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“…The model-fitting results showed that BEO-loaded zein nano-fibers could be a delivery vehicle for diabetes control. Karimlar et al,(2019) exposed the hypoglycemic and hypolipidemic effects of three medicinal plants' essential oils including F. gummosa on streptozotocin-induced diabetic rats. For the experimental setup the streptozotocin-induced (45 mg/kg doses, intraperitoneally) male wistar rats were used and treated with the essential oil (200 mg/kg/day).…”

Section: Hypoglycemic and Hypolipidemic Effectmentioning

confidence: 99%

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

Sonigra

Meena

2021

Front. Pharmacol.

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The genus Ferula is the third largest and a well-known genus of the Apiaceae family. It is categorized in the Peucedaneae tribe and Ferulinae subtribe of the Apiaceae family. At present, about 180 Ferula species have been reported. The genus is mainly distributed throughout central and South-West Asia (especially Iran and Afghanistan), the far-East, North India, and the Mediterranean. The genus Ferula is characterized by the presence of oleo-gum-resins (asafoetida, sagapenum, galbanum, and ammoniacum) and their use in natural and conventional pharmaceuticals. The main phytochemicals present in the genus Ferula are as follows: coumarin, coumarin esters, sesquiterpenes, sesquiterpene lactones, monoterpene, monoterpene coumarins, prenylated coumarins, sulfur-containing compounds, phytoestrogen, flavonoids and carbohydrates. This genus is considered to be a valuable group of medicinal plants due to its many different biological and pharmacological uses as volatile oils (essential oils). Numerous biological activities are shown by the chemical components of the essential oils obtained from different Ferula species. Because this genus includes many bioactivities such as antimicrobial, insecticidal, antioxidant, cytotoxic, etc., researchers are now focusing on this genus. Several reviews are already available on this particular genus, including information about the importance and the uses of all the phytochemicals found in the species of Ferula. Despite this, no review that specifically provides information about the biological activities of Ferula-derived essential oils, has been published yet. Therefore, the present review has been conducted to provide important information about the chemical profile, factors affecting the chemical composition, and biological activities of essential oils of the Ferula species.

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