Hypoglycemic Effect of Aqueous Shallot and Garlic Extracts in Rats with Fructose-Induced Insulin Resistance

Abstract

Summary The present study has been carried out to investigate the effect of aqueous extract of shallot (Allium ascalonicum) and garlic (Allium satium) on the fasting insulin resistance index (FIRI) and intraperitoneal glucose tolerance test (IPGTT) of fructose-induced insulin resistance rats. Male albino Wistar rats were fed either normal or high-fructose diet for a period of eight weeks. Fasting blood glucose level, fasting blood triglyceride level, FIRI, and the area under the glucose tolerance curve were significantly elevated in fructose-fed animals. Fructose-induced insulin resistance rats treated by aqueous shallot or garlic extract (500 mg/ kg body weight/day, i.p.) for duration of eight weeks. Control animals only received normal saline (0.9%). The results showed that neither shallot nor garlic extracts significantly altered the FIRI and the IPGTT at the fourth week after treatment. The fasting blood glucose in fructose-induced insulin resistance animals has been significantly decreased in 8-week treated animals by both shallot and garlic extracts. Shallot extract administration, but not garlic extract, for a period of eight weeks can significantly improve the intraperitoneal glucose tolerance and diminish the FIRI. These results indicate that shallot and garlic extracts have a hypoglycemic influence on the fructose-induced insulin resistance animals and aqueous shallot extract is a stronger hypoglycemic agent than the garlic extract.

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

“…In addition, extracts of garlic contains various biologically active compounds such as alliin, allicin, ally methanethiosulfinate, ajoene, diallyl disulfide, diallyltrisulfide, and S-allylycysteine [150]. It is widely known that garlic produces various biological benefits, which include hypocholesterolemic [151], hypoglycemic [152], antihypertensive [153], anticancer [154] and antioxidant effects [155].…”

Effects of Micronutrient Fortifi ed Milk and Cereal Food for Infants and Children: A Systematic Review

“…Although the antidiabetic effect of raw garlic has been well established in the type 1 experimental diabetic model [6][7][8][9][10] only one experimental study has been conducted so far to evaluate the effect of garlic on insulin resistance in rats [11]. However, in the study by Jalal et al [11] since low dose fructose was administered, only a marginal increase in blood glucose levels (~8%) was observed while the metabolic syndrome was not well characterized.…”

Pharmacodynamic interactions between drugs and dietary supplements

“…Since garlic possesses hypoglycaemic 28,29 and hypolipaemic effects, the interaction with antidiabetic drugs and cholesterol/triglyceride lowering drugs is possible. In an unreliable report from 1979, a fall in glucose levels in a 40-year-old diabetic woman taking chlorpropamide and a curry containing garlic and karela has been reported.…”