Hypoglycemic effect of cotton seed aqueous extract in alloxan-induced diabetes mellitus in rats

Sadique, J.; Begum, V. Hazeena; Thenmozhi, V.; Elango, V.

doi:10.1016/0885-4505(87)90067-3

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…The literature regarding the effect of diabetes on liver weight is contradictory as some workers have shown an increase in hepatic weight in animals (Chen and Ianuzzo, 1982;Sadique et al, 1987;Murphy and Anderson, 1974) as well as humans (Van Lancker, 1976) while others have reported no change (Gupta et al, 1999). In the present case diabetic rats showed significantly higher liver weight/100 g body weight and this ratio was not altered by OS.…”

Section: Discussioncontrasting

confidence: 48%

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Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats

Vats

Yadav

Grover

2004

Journal of Ethnopharmacology

198

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Section: Discussioncontrasting

confidence: 48%

“…In the present case diabetic rats showed significantly higher liver weight/100 g body weight and this ratio was not altered by OS. Exact reasons of hepatic hypertrophy are not known, however fat deposition has been proposed to be the cause (Sadique et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats

Vats

Yadav

Grover

2004

Journal of Ethnopharmacology

198

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“…Only the DT250-treated group showed a significant reduction in liver weight. The literature regarding the effect of diabetes on liver weight is contradictory, as some studies have shown an increase in hepatic weight [37], while others report no change [38]. With regard to kidney weight, the treatment with HEPA caused a significant reduction.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)

Leite

Araújo

Carvalho

et al. 2010

Evidence-Based Complementary and Alternative Medicine

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This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal and alloxan-induced diabetic rats, treated with HEPA (125 and 250 mg/kg; p.o.). Oral glucose tolerance test, acute oral toxicity test and preliminary phytochemical analyses were performed. The diabetic rats treated with HEPA showed a significant reduction in serum and urinary glucose, urinary urea and triglyceride levels, as compared to the diabetic untreated group. However, in the normal treated groups, a significant reduction was found only in serum triglyceride levels. In all treated diabetic groups, an improvement in hepatic glycogen was observed, as well as a decrease in liquid intake and urinary volume, and an enhancement in the weight of skeletal muscles (soleus and extensor digitorum longus), kidneys and epididymal adipose tissue. Nevertheless, body and liver weights were ameliorated only in the diabetic group treated with HEPA (250 mg/kg). Moreover, oral glucose tolerance was higher in animals treated with HEPA, while results also showed that HEPA could be considered toxicologically safe. Phytochemical analysis revealed the presence of tanins, flavonoids and steroids in HEPA. In conclusion, P. aculeata presents an antidiabetic activity and other beneficial effects that ameliorate diabetes and associated complications.

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“…Brain and heart glycogen content remained unaltered in the experimental groups and this is in agreement with previous findings. 20,21 The literature regarding the effect of diabetes on liver weight is contradictory as some workers have shown an increase in hepatic weight in animals [28][29][30] as well as humans 31 while others have reported no change. 32 In the present case, diabetic rats showed significantly higher liver weight/100 g body weight and this ratio was not altered by H. isora.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats

Ganesan

Banu²,

Murugesan

2009

Hum Exp Toxicol

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The present study was undertaken to assess the effect of Helicteres isora L. on four important enzymes of carbohydrate metabolism (glucokinase [GK], hexokinase [HK] phosphofructokinase [PFK] and fructose-1, 6-bisphosphatase [FBP]) along with glycogen content of insulin-dependent (skeletal muscle and liver) and insulin-independent tissues (kidneys and brain) in streptozotocin (STZ; 60 mg/kg)-induced model of diabetes for 30 days. Administration of bark extracts (100, 200 mg/kg) for 30 days led to decrease in plasma glucose levels by approximately 9.60% and 22.04% and 19.18% and 33.93% on 15th and 30th day, respectively, of the experiment. Liver and two-kidney weight expressed as percentage of body weight significantly increased in diabetics (P < 0.05) versus normal controls. Renal glycogen content increased by 10 folds while hepatic and skeletal muscle glycogen content decreased by 75% and 68% in diabetic controls versus controls. H. isora did not affect glycogen content in any tissue. The decreased activities of PFK, GK, FBP and HK in diabetic controls were 40%, 50%, 50% and 60% and bark extract of H. isora partially corrected this alteration. The efficacy of the bark extract was comparable with Tolbutamide, a well-known hypoglycemic drug.

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Hypoglycemic effect of cotton seed aqueous extract in alloxan-induced diabetes mellitus in rats

Cited by 7 publications

References 19 publications

Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats

Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats

Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)

Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats

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