Hypoglycemic effect of Otostegia persica in normoglycemic and streptozotocin induced diabetic rats

Sadeghi, Heibatollah; Mohsenian, Leilla; Akbartabar, Mehdi; Najafi, Maryam; Mirzaee, Ali; Mohammadi, Reza

doi:10.1016/j.clinbiochem.2011.08.844

Cited by 1 publication

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“…These effects were also more pronounced in 100 mg/kg/day dose compared to 25 mg/kg/day. Sadeghi et al reported similar results from Achillea wilhelmsii on blood glucose in male rats [3]. In another study, a similar effect for Achillea millefolium extract was also obtained [12].…”

Section: Discussionsupporting

confidence: 53%

“…Various forms of DM have widely been identified whereas type 2 DM is the most common and possessed more than 85% of all diabetic cases. Herbal drugs are used as alternatives for routine drugs for diabetic patients [3]. One of these herbal drugs is derived from Achillea millefolium belonging to the Asteraceae family and possessed a variety of pharmaceutical benefits, traditionally used in the amelioration of diabetes, high blood pressure, renal stones, muscle pain, acne, and bleeding [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Herbal drugs are used as alternatives for routine drugs for diabetic patients [3]. One of these herbal drugs is derived from Achillea millefolium belonging to the Asteraceae family and possessed a variety of pharmaceutical benefits, traditionally used in the amelioration of diabetes, high blood pressure, renal stones, muscle pain, acne, and bleeding [3,4]. These effects are attributed to essential compounds in Achillea species such as tanene, terepen, acetylen, lacton and razin.…”

Section: Introductionmentioning

confidence: 99%

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Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats

et al. 2020

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Background Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. This study aimed to investigate the effects of Achillea millefolium hydroalcoholic extract in comparison to metformin on liver damage, lipid abnormality, and glycemic control in diabetic rats. Methods Rats were randomly assigned to 7 groups of 10 animals. Diabetes was induced by injection of streptozotocin (STZ) to 4 groups of rats. Three groups of diabetic rats were given 250 mg/kg/day metformin, 25 mg/kg/day Achillea millefolium hydroalcoholic extract, or 100 mg/kg/day of this extract. Two non-diabetic groups were also given either 25 mg/kg/day or 100 mg/kg/day Achillea millefolium extract. Normal control and diabetic control rats received 1 mL/day of normal saline. Treatments were administered through oral gavage for 28 days. At the end, rats were anesthetized with ether and their serum samples were separated in order to measure blood glucose, serum total protein, lipids, and liver enzymes. Results There was a significant reduction in blood glucose, serum liver enzymes, triglycerides, and total- and LDL-cholesterol levels of the Achillea millefolium extract-treated groups compared to the other groups. In addition, there was a significant increment in body weight and HDL-cholesterol serum level in the Achillea millefolium-treated groups. Conclusion Achillea millefolium extract compared to metformin reduces lipid abnormality, blood glucose and liver enzymes in STZ-induced diabetic rats. Future clinical studies are warranted to confirm our experimental findings in humans.

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Section: Discussionsupporting

confidence: 53%