Hypoglycemic effects of Aqueous and Methanolic Leaf Extracts of Vitex doniana on Alloxan Induced Diabetic Albino Rats

Obasi, Nwogo Ajuka; Kalu, Kalu Mong; Okorie, Uchechukwu; Otuchristi, G.

doi:10.3923/jms.2013.700.707

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…Hyperglycemia can result in increased protein glycation. A high level of total bilirubin suggests an excess breakdown of hemoglobin or a malfunction in liver function in relation to hemoglobin [25]. From Table 4, the total bilirubin and conjugated bilirubin levels were significantly higher (P≤ 0.05) in the diabetic control rats, which may be related to decreased in liver uptake, this indicates that diabetes affects the aforementioned clinical conditions as compared to normal control on Table 4.…”

Section: Effect Of Crude Aqueous Extract Of V Subterrenea Leaf Nut St...mentioning

confidence: 89%

“…Bilirubin is formed through the breakdown of heme and is eliminated from the body by the liver [25]. It is a known fact that measuring bilirubin levels is an essential test for evaluating liver function since an elevated level of bilirubin in the blood may indicate problems with the liver's excretory function, excessive hemolysis, or obstruction in the biliary tract.…”

Section: Effect Of Crude Aqueous Extract Of V Subterrenea Leaf Nut St...mentioning

confidence: 99%

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Evaluation of Antidiabetic Effect of Crude Aqueous Extract of Nut, Leaf and Stem Parts of Vigna subterranae on Streptozotocin-Induced Diabetic Rats

Abigail,

Godwin,

Uduakobong

et al. 2023

IJBcRR

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Diabetes is a metabolic disorder characterized by abnormally high blood glucose level. One of the plants frequently used to manage diabetes is Vigna subterrenea, also known as the Bambaranut. The aim of this study is to verify the usefulness of this plant to mitigate the effects of diabetes. Thirty (30) Wistar rats weighing 170-200 g were used for this evaluation, the rats were randomly divided into six groups namely; group A: normal control, group B: diabetic control, group C: metformin (500 mg), group D: leaf extract (1000 mg), group E: stem extract (1000 mg), and group F: nut extract (1000 mg). Alkaloids, flavonoids, saponins, balsam carbohydrate, phenol, steroids, and cardiac glycosides were all identified during the phytochemical screening of aqueous extracts. Intraperitoneal injections were used to cause diabetes using streptozotocin across groups and treatment commenced after 48 hours of induction upon confirmation of diabetes mellitus. The sacrifices of animals occurred after a 28-day session of treatment. For hematological and biochemical examination, blood, liver, kidney, and pancreas were obtained. Significantly lowering of fasting blood sugar in the extract treatment groups resulted in improved biochemical markers (P≤0.05). Serum enzyme markers showed a significant drop (P≤0.05) while High Density Lipoprotein (HDL) level increased considerably when compared with diabetic control. Also, when compared to the diabetic control group, the markers of kidney function all noticeably dropped, while electrolyte levels rose. Additionally, there was a significant positive impact on hematological parameters. In accordance with the results of this investigation, V subterrenea is a potent hypoglycemia and hypolipidemic agent on streptozotocin-induced diabetic rats.

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Section: Effect Of Crude Aqueous Extract Of V Subterrenea Leaf Nut St...mentioning

confidence: 89%

Section: Effect Of Crude Aqueous Extract Of V Subterrenea Leaf Nut St...mentioning

confidence: 99%

Evaluation of Antidiabetic Effect of Crude Aqueous Extract of Nut, Leaf and Stem Parts of Vigna subterranae on Streptozotocin-Induced Diabetic Rats

Abigail,

Godwin,

Uduakobong

et al. 2023

IJBcRR

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“…Dysfunction in lipid and carbohydrate metabolism is one of many symptoms of diabetes [56], free radical overproduction is the main cause of the elevated lipid peroxidation seen in DM. Glycosylated proteins, auto-oxidation, decreased levels of the enzyme superoxide dismutase, decrease ascorbic acid, shortage of reduced glutathione are other variables that cause oxidative stress [57].…”

Section: Analysis On Lipid Profilementioning

confidence: 99%

Determination of Antihypergycemic Effect of Flaxseed (L. usititatissimum) Fractions on Streptozotocin-induced Diabetic Rats

Abigail,

Godwin,

Uduakobong

et al. 2023

AJRB

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Diabetes is a metabolic disorder characterized by persistent high blood glucose level. Flaxseed is one of the functional foods used in the management of diabetes mellitus. The study aimed to evaluate the effects of different fractions of Flaxseed on albino diabetic rats, and diabetes was induced using streptozotocin. The fractions were obtained using solvents with increasing polarity, namely n-Hexane, Ethylacetate, Methanol, and Water. The presence of various phytochemicals, including alkaloids, flavonoids, tannins, saponins, balsam, carbohydrates, phenols, and resins, were identified. The phytochemical analysis revealed that the methanolic fraction contained the highest concentration of bioactive components, followed by the aqueous fraction. Significant reductions in blood glucose levels were observed across the groups treated with the Flaxseed fractions. The methanolic fraction exhibited the highest antihyperglycemic property (5.90±0.536), followed by the aqueous fraction (8.73±0.536). The hexane fraction ranked next to the aqueous fraction (20.50±1.617), while the ethylacetate fraction had the least antihyperglycemic effect (23.60±0.731). However, the protein and albumin biomarkers showed significant increase across all treatment groups. The Flaxseed fractions also demonstrated antihyperlipidemic properties, with the methanolic fraction being the most potent. Additionally, the treatment groups exhibited improved kidney function biomarkers, serum enzyme levels, and electrolyte levels. Based on the results of this investigation, Flaxseed proves to be a potent antihyperglycemic and antihyperlipidemic food. Moreover, the methanolic fraction demonstrated the greatest ameliorative effect, followed by the aqueous fraction.

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“…Peptic ulcer affects about 5−10% of the world population within the span of their life-time (Garrow and Delegge, 2010) and the synthetic drugs utilized for its treatment have numerous adverse effects in humans. Currently, plants widely applied for the prevention and treatment of well-known diseases are constantly evolving in the developing world since they have no adverse health effects (Mahmood et al, 2011;Obasi et al, 2013). Plants contain bioactive compounds with potentials for effective treatment of diseases such as cancer, rheumatism and inflammatory diseases, etc.…”

Section: Introductionmentioning

confidence: 99%

“…(Atawodi, 2005;Bardi et al, 2011). The curative potentials of these plants serve as catalysts for exploring and probing their activities, especially the commonly wild underutilized medicinal plants Obasi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Dialium guineense pulp on aspirin-induced gastric mucosal injury in albino rats

Obasi¹,

Aloke²,

Obasi³

et al. 2021

J Appl Biomed

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The numerous challenges and detrimental effects connected with the treatment of peptic ulcers in the world today calls for alternative attention. Ethnomedicinally, Dialium guineense pulp (DAGP) has numerous pharmacological activities. This study investigated the antiulcer activities of Dialium guineense pulp on gastric mucosa injury induced with aspirin in albino Wistar rats. DAGP extract was orally administered at doses of 250, 500 and 1000 mg/kg bw (mg per kg of the body weight) per day for 3 or 7 days followed by 400 mg/kg bw oral aspirin administration. Ulcer indices were determined, followed by a biochemical estimation of antioxidant enzymes using gastric mucosal tissue from the stomach. Student's t-test was used to compare significant differences among groups of animals at P ≤ 0.05. The results showed that Dialium guineense pulp caused a significant decrease (P ≤ 0.05) in the ulcer index in aspirin induced rats. This decrease in ulcer index is dose dependent and 1000 mg/kg bw per day caused the highest decrease in 7 days. The results showed a significant increase (P ≤ 0.05) in lipid peroxidation and a decrease (P ≤ 0.05) in antioxidant enzymes activities in the aspirin-induced ulcerated rats. Oral administration of DAGP increased antioxidant enzymes activities and decreased injury in the gastric mucosa in ulcer induced rats. Therefore, this study showed that DAGP exhibited anti-ulcer potential and that the gastrointestinal protection may be through the scavenging action of free radicals by its constituent antioxidants. Thus, Dialium guineense pulp has ameliorative medicinal potential for the curing of gastric disorders.

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Hypoglycemic effects of Aqueous and Methanolic Leaf Extracts of Vitex doniana on Alloxan Induced Diabetic Albino Rats

Cited by 6 publications

References 5 publications

Evaluation of Antidiabetic Effect of Crude Aqueous Extract of Nut, Leaf and Stem Parts of Vigna subterranae on Streptozotocin-Induced Diabetic Rats

Evaluation of Antidiabetic Effect of Crude Aqueous Extract of Nut, Leaf and Stem Parts of Vigna subterranae on Streptozotocin-Induced Diabetic Rats

Determination of Antihypergycemic Effect of Flaxseed (L. usititatissimum) Fractions on Streptozotocin-induced Diabetic Rats

Protective effects of Dialium guineense pulp on aspirin-induced gastric mucosal injury in albino rats

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