Hypoglycemic Effects of Lycium barbarum Polysaccharide in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota

Ma, Qingyu; Zhai, Ruohan; Xie, Xiaoqing; Chen, Tao; Zhang, Ziqi; Liu, Huicui; Nie, Chenxi; Yuan, Xiaojin; Tu, Aobai; Tian, Baoming; Zhang, Min; Chen, Zhifei; Li, Juxiu

doi:10.3389/fnut.2022.916271

Cited by 50 publications

(39 citation statements)

References 83 publications

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“…Polysaccharides, as the bioactive macromolecular constituents of many medicinal herbs, have been broadly used in the therapy of T2D ( Zheng et al, 2019 ). A growing number of preclinical studies demonstrated that certain herbal polysaccharides exhibited the antidiabetic effect via regulating the disordered gut microbiota community ( Hu et al, 2018 ; Wu et al, 2019 ; Ma et al, 2022 ). Ginseng polysaccharides was observed to decrease the fasting blood glucose significantly and restore the dysbiosis of gut microbiota system by decreasing the abundance of Proteobacteria ( Li et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice

Song

Cheng

et al. 2022

Front. Pharmacol.

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Gut microbiota has been reported to be closely associated with Type-II diabetes. Restoration of disordered gut microbiota ecosystem has been developed into a therapeutic strategy and gradually applied on Type-II diabetes treatment with both western drugs and herbal polysaccharides. Although Astragalus membranaceus polysaccharides (AMP) have also been used to treat Type-II diabetes, no study investigated correlations between gut microbiota regulation and its hypoglycemic effect. In the present study, the role of gut microbiota on the hypoglycemic effect of AMP in db/db mice was investigated for the first time. Sixteen days treatment of AMP at the dosage of 600 mg/kg in db/db mice not only alleviated its diabetic symptoms significantly but also restored its gut microbiota community with increased production of fecal short chain fatty acids (SCFA). Our further Pearson correlation analyses revealed that the relative abundance of two intestinal bacteria, Akkermansia and Faecalibaculum, were significantly positively correlated with the hypoglycemic effect of AMP as well as fecal SCFA production. It was also noted that treatment of AMP resulted in increased secretion of glucagon-like peptide-1 (GLP-1) in serum and enhanced intestinal integrity. Further mechanistic study revealed that the increased SCFA after AMP treatment could stimulate GLP-1 secretion and improve intestinal integrity via enhancing the expression of G protein-coupled receptors 41/43 and tight junction proteins (Occudin and ZO-1), respectively, leading to the alleviation of diabetic symptoms in db/db mice.

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Section: Introductionmentioning

confidence: 99%

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice

Song

Cheng

et al. 2022

Front. Pharmacol.

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“…These findings coincide with the correlation between microbiota and metabolic phenotypes in our study. However, other studies claim Alistipes positively correlates with glucose intolerance (Han et al, 2020;Li et al, 2022), while Allobaculum (Li et al, 2017;Wang et al, 2017), Acetatifactor (Zhao et al, 2022) and Intestinimonas (Cai et al, 2020;Ma et al, 2022) are beneficial genera in glucose metabolism.…”

Section: Discussionmentioning

confidence: 94%

Surrogate fostering of mice prevents prenatal estradiol-induced insulin resistance via modulation of the microbiota-gut-brain axis

Zhou

Sun

2023

Front. Microbiol.

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IntroductionPrenatal and early postnatal development are known to influence future health. We previously reported that prenatal high estradiol (HE) exposure induces insulin resistance in male mice by disrupting hypothalamus development. Because a foster dam can modify a pup’s gut microbiota and affect its health later in life, we explored whether surrogate fostering could also influence glucose metabolism in HE offspring and examined mechanisms that might be involved.MethodsWe performed a surrogate fostering experiment in mice and examined the relationship between the metabolic markers associated to insulin resistance and the composition of the gut microbiota.ResultsHE pups raised by HE foster dams (HE-HE) developed insulin resistance, but HE pups fostered by negative control dams (NC-HE) did not. The gut microbiota composition of HE-HE mice differed from that of NC mice raised by NC foster dams (NC-NC), whereas the composition in NC-HE mice was similar to that of NC-NC mice. Compared with NC-NC mice, HE-HE mice had decreased levels of fecal short-chain fatty acids and serum intestinal hormones, increased food intake, and increased hypothalamic neuropeptide Y expression. In contrast, none of these indices differed between NC-HE and NC-NC mice. Spearman correlation analysis revealed a significant correlation between the altered gut microbiota composition and the insulin resistance-related metabolic indicators, indicating involvement of the microbiota-gut-brain axis.DiscussionOur findings suggest that alterations in the early growth environment may prevent fetal-programmed glucose metabolic disorder via modulation of the microbiota-gut-brain axis. These findings offer direction for development of translational solutions for adult diseases associated with aberrant microbial communities in early life.

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“…Similarly, the effects of Lycium barbarum Polysaccharide (LBP) on T2DM in mice were mediated via modulation of gut microbiota. The results showed that LBP notably improved the composition of intestinal flora, increasing the relative abundance of Bacteroides , Ruminococcaceae _UCG-014, Intestinimonas , Mucispirillum , and Ruminococcaceae _UCG-009, and decreasing the relative abundance of Allobaculum , Dubosiella , and Romboutsia [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…Polysaccharides have a preventive effect on certain diseases, such as diabetes and heart disease, which may increase the utilization of polysaccharides as food ingredients or pharmaceutical additives. Polysaccharides can directly or indirectly stimulate a variety of immune cells in mice, regulate the immune function of the body, and also exhibit hypoglycemic activity via intestinal flora in rats [ 15 , 16 , 17 ]. Increasing evidence suggests that polysaccharides may be an ideal functional food for the prevention or treatment of some diseases [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Millet Bran Polysaccharides Partially Mediated via Changes in Gut Microbiome

Jin-hua

Wang

Guo

et al. 2022

Foods

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Diabetes is a type of metabolic disease associated with changes in the intestinal flora. In this study, the regulatory effect of millet bran on intestinal microbiota in a model of type 2 diabetes (T2DM) was investigated in an effort to develop new approaches to prevent and treat diabetes and its complications in patients. The effect of purified millet bran polysaccharide (MBP) with three different intragastric doses (400 mg/kg, 200 mg/kg, and 100 mg/kg) combined with a high-fat diet was determined in a streptozotocin (STZ)-induced model of T2DM. By analyzing the changes in indicators, weight, fasting blood sugar, and other bio-physiological parameters, the changes in gut microbiota were analyzed via high-throughput sequencing to establish the effect of MBP on the intestinal flora. The results showed that MBP alleviated symptoms of high-fat diet-induced T2DM. A high dosage of MBP enhanced the hypoglycemic effects compared with low and medium dosages. During gavage, the fasting blood glucose (FBG) levels of rats in the MBP group were significantly reduced (p < 0.05). The glucose tolerance of rats in the MBP group was significantly improved (p < 0.05). In diabetic mice, MBP significantly increased the activities of CAT, SOD, and GSH-Px. The inflammatory symptoms of liver cells and islet cells in the MBP group were alleviated, and the anti-inflammatory effect was partially correlated with the dose of MBP. After 4 weeks of treatment with MBP, the indices of blood lipid in the MBP group were significantly improved compared with those of the DM group (p < 0.05). Treatment with MBP (400 mg/kg) increases the levels of beneficial bacteria and decreases harmful bacteria in the intestinal tract of rats, thus altering the intestinal microbial community and antidiabetic effect on mice with T2DM by modulating gut microbiota. The findings suggest that MBP is a potential pharmaceutical supplement for preventing and treating diabetes.

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Hypoglycemic Effects of Lycium barbarum Polysaccharide in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota

Cited by 50 publications

References 83 publications

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice

Surrogate fostering of mice prevents prenatal estradiol-induced insulin resistance via modulation of the microbiota-gut-brain axis

Antidiabetic Effect of Millet Bran Polysaccharides Partially Mediated via Changes in Gut Microbiome

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