Hypoglycemic herbs and their action mechanisms

Hui, Hongxiang; Tang, George; Go, Vay Liang W.

doi:10.1186/1749-8546-4-11

Cited by 162 publications

(121 citation statements)

References 94 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…This action could be due to enhanced insulin secretion from the beta cells, improved glucose utilization and transport. 63 These results are consistent with earlier finding which have also reported significant improvement in oral glucose tolerance in C. fistula extract treated diabetic rats. 41,64 Glycosylated hemoglobin is considered as the most reliable marker of glycemic control in the body.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Jangir¹,

Jain²

2017

View full text Add to dashboard Cite

Background: Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the world. Many Indian medicinal plants have been reported to possess potential antidiabetic activity and could play important role in the management diabetes. Objective: The present study aimed to evaluate antidiabetic activities of 70% ethanolic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (60 mg/kg b.wt.). The diabetic rats were administered orally with C. fistula pod extract at three different doses (100, 250 and 500 mg/kg b.wt./day) for 60 days. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. Results: The streptozotocin treated diabetic control rats showed a significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels with a concomitant decrease in the body weight and glycogen content in the liver as compared to normal control rats. Oral administration of C. fistula pod extract (100, 250 and 500 mg/kg b.wt./day) or glibenclamide for 60 days showed significant reduction in the blood glucose and HbA1c levels and an elevation in the body weight and hepatic glycogen content as compared to diabetic control rats. Furthermore, treatment with extract (500 mg/kg b.wt.) also showed improvement of oral glucose tolerance test (OGTT) in diabetic rats. These results were comparable to glibenclamide. Conclusion:The results of present study showed that C. fistula pod extract possess significant antihyperglycemic activity and supports the traditional use of C. fistula pod for the treatment of diabetes mellitus. Key words: Antidiabetic, Blood glucose, Cassia fistula, Glycogen, Glycosylated hemoglobin, Streptozotocin. Cite this article : Jangir RN, Jain GC. Evaluation of antidiabetic activity of hydroalcoholic extract of Cassia fistula Linn. pod in streptozotocin-induced diabetic rats. Pharmacog J. 2017;9(5):599-606. Ram Niwasphytochemicals. Many Indian medicinal plants have been found to be useful in the management of diabetes acting though variety of mechanisms. Medicinal plants provide better alternatives as they are less toxic, easily available and affordable and many of the currently available drugs have been derived directly or indirectly from them. 6,7 Cassia fistula Linn. (Hindi-Amaltas; EnglishGolden Shower or Indian Laburnum), a medium sized tree belonging to the family-Caesalpiniaceae, is cultivated throughout India as an ornamental plant and is used widely for its medicinal properties. Almost every part of C. fistula are used extensively in the folklore medicine for the treatment of a variety of diseases. 8,9 The dried pod and pulp are valued for their laxative properties. The pulp is considered a safe purgative, recommended for pregnant women and children to relieve disorders of the liver and biliousness. It is a remedy for malaria and black water fever. It is also used to...

show abstract

Section: Discussionsupporting

confidence: 83%

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Jangir¹,

Jain²

2017

View full text Add to dashboard Cite

show abstract

“…81 Ginseng, a common ingredient in many energy drinks, may lower blood glucose levels, but its actions in energy drinks are unclear. 82 …”

Section: Effects Of Caffeine In Children and Adolescentsmentioning

confidence: 99%

Health Effects of Energy Drinks on Children, Adolescents, and Young Adults

et al. 2011

View full text Add to dashboard Cite

"poison control center" to identify articles related to energy drinks. Manufacturer Web sites were reviewed for product information. RESULTS:According to self-report surveys, energy drinks are consumed by 30% to 50% of adolescents and young adults. Frequently containing high and unregulated amounts of caffeine, these drinks have been reported in association with serious adverse effects, especially in children, adolescents, and young adults with seizures, diabetes, cardiac abnormalities, or mood and behavioral disorders or those who take certain medications. Of the 5448 US caffeine overdoses reported in 2007, 46% occurred in those younger than 19 years. Several countries and states have debated or restricted energy drink sales and advertising. CONCLUSIONS:Energy drinks have no therapeutic benefit, and many ingredients are understudied and not regulated. The known and unknown pharmacology of agents included in such drinks, combined with reports of toxicity, raises concern for potentially serious adverse effects in association with energy drink use. In the short-term, pediatricians need to be aware of the possible effects of energy drinks in vulnerable populations and screen for consumption to educate families. Long-term research should aim to understand the effects in at-risk populations. Toxicity surveillance should be improved, and regulations of energy drink sales and consumption should be based on appropriate research.

show abstract

“…Hyperglycemia is involved in the etiology of development of diabetic complications. Hypoglycemic herbs increase insulin secretion, enhance glucose uptake by adipose or muscle tissues and inhibit glucose absorption from intestine and glucose production from liver [19] . Insulin and oral hypoglycemic agents like sulphonylureas and biguanides are still the major players in the management, but there is quest for the development of more effective anti-diabetic agents.…”

Section: Plant-based Anti-diabetic Medicinementioning

confidence: 99%